d-GLUCOSE TOLERANCE IN HEALTH AND DISEASE

The Relation of the Hypophysis to Diabetes Mellitus1

“…Finally in this connection, Wilder and Sansum giving glucose intravenously continuously and at constant rates in 2 cases of dyspituitarism showing the Frijhlich syndrome (96), found that when an administration rate of approximately 0.8 gram glucose per kilogram per hour was exceeded, glycosuria occurred (as determined by a qualitative test). They observed essentially the same assimi-L L lation limit in their 4 normal controls.…”

Blood Sugar Reaction Following Intravenous Injection of Glucose

“…and Sansum,12 Kleiner,19 Nonnenbruch and Szyszka 20 and Bang.21 Blumenthal,13 in 1904, attempted to determine glucose tolerance by the intravenous method, but he made no blood sugar estimations, depending on the production of glycosuria and leaving out of consideration the permeability of the kidneys. In 1913, Tannhauser and Pfitzer 14 made the first clinical attempt to determine the hyperglycemia caused in man by the injection of small amounts of glucose solution into a vein.…”