D-limonene possesses cytotoxicity to tumor cells but not to hepatocytes

Neuroprotective potential of terpenoid-rich extracts from orange juice by-products obtained by pressurized liquid extraction

“…Other possible explanation for this results may be the large presence of ascorbic acid in orange sample, that could exert a synergic and confounding factor ( Mohammadian et al, 2011 ). In fact, monoterpenoids such as limonene present in large amount in orange peel showed important antioxidant activity ( Shah et al, 2019 ).…”

“…Different studies have evaluated the citotoxicity of some of the main components in orange extracts. This is the case for limonene ( Shah et al, 2019 ) and valencene ( Yang et al, 2016 ) but also the whole orange extracts have been studied ( Atolani et al, 2020 ). These reports have shown that the most abundant compounds as well as the whole extracts are safe for organisms which may support the future use of the obtained PLE100 extract.…”

In vitro evaluation of antioxidant activity of D-Limonene

“…In our previous studies, we have reported that D-Limonene has inhibited the growth of K562, chronic myeloid leukemia cells in vitro without producing any toxicity on primary hepatocytes isolated from the mouse (Shah et al, 2018).…”

In Silico Prediction of Selected Bioactive Compounds Present in Alpinia elegans (C.Presl) K.Schum Seed Oil as Potential Drug Candidates Against Human Cancer Cell Lines

“…On the other hand, it was shown in Table 5 that caryophyllene oxide and D-limonene pose cytotoxic activity on normal human cell lines. It is an important obligatory step to determine as well because, through this normal cell line determination, researchers may be able to assess and specify which cell line to focus on for evaluation of the compounds, which in turn may lead to the discovery of metabolite development, which can become an ultimate source of toxicity study for possible cancer treatment (Shah et al, 2019;Calhelha et al, 2014). Through the studies mentioned, α-pinene, caryophyllene oxide, and D-limonene all have expressed anticancer, among other pharmacological effects, which aligns with the generated results of them inhibiting cell lines from the CLC-Pred.…”