D-Mannose Suppresses γδ T Cells and Alleviates Murine Psoriasis

Abstract

Psoriasis is a chronic skin disorder associated with multiple sequelae, such as psoriatic arthritis and cardiovascular diseases. Increasing evidence has shown that γδ T cells, as sources of IL-17A, play critical roles in psoriatic inflammations. However, there still lack effective ways to manipulate these pathogenic γδ T cells, which are less well studied than αβ T cells. The present study aims to characterize the phenotype of γδ T cells and evaluate the impact of D-mannose (a C-2 epimer of glucose) on γδ T cell-mediated psoriasis. We found that skin-draining LN γδ T cells underwent robust proliferation and acquired an IL-17-producing phenotype during psoriasis. The transcriptomic profiles of these psoriatic γδ T cells had elevated glycolytic signatures. Importantly, D-mannose treatment suppressed the γδ T cell reaction and successfully alleviated the local and systematic inflammation induced by imiquimod. The decreased AKT/mTOR/HIF-1α signaling and glycolytic ability may contribute to the suppression of γδ T cells achieved by D-mannose. Our study increased understanding of γδ T cells in psoriasis and promoted D-mannose utilization as a potential clinical application for autoimmune diseases driven by γδ T cells.

Reversal of the detrimental effects of social isolation on ischemic cerebral injury and stroke-associated pneumonia by inhibiting small intestinal γδ T-cell migration into the brain and lung

“…Moreover, in murine models of psoriasis, the migration of IL-17A-producing cd T cells between skin-draining lymph nodes and the dermis play a critical role in the pathology of psoriasis; 95 furthermore, depletion of cd T cells can alleviate skin inflammation. 96 Collectively, these results indicate that migratory cd T cells function as an important proinflammatory population in the induction of pathology in a variety of diseases. In our study, we observed significantly increased intestinal, cerebral and pulmonary permeability in ISO mice subjected to MCAO.…”

LC–MS metabolomics reveal skin metabolic signature of psoriasis vulgaris

“…Mannose can upregulate the expression of peroxisome proliferator‐activated receptor γ (PPARγ) and downregulate the growth factor β1 (TGF‐β1) by increasing MR expression, which has anti‐inflammatory and anti‐proliferative effects 36,37 . A recent study revealed that D‐mannose could alleviate the IMQ‐induced psoriasis by suppression of γσT cells, which may be related to the downregulation of AKT/mTOR/HIF‐1ɑ signalling and glycolyic activity 38 …”

“…36,37 A recent study revealed that D-mannose could alleviate the IMQ-induced psoriasis by suppression of γσT cells, which may be related to the downregulation of AKT/mTOR/HIF-1ɑ signalling and glycolyic activity. 38…”

Tuning the Electronic Structures of TMNs‐Modified Ni‐Based Catalysts to Enhance the Performance for MOR in Alkaline Media

“…Transition metal nitrides have attracted great attention because of their low resistance, good mechanical strength and corrosion resistance to various electrocatalytic reactions, such as HER, [21–23] ORR, [24,25] MOR [26–28] and EOR [29,30] . For the MOR and EOR, several transition metal nitrides have been employed as the electrocatalysts and exhibited good catalytic activity and stability [31–35] . For example, Khoshroo et al [31] .…”

“…It could be indicated that Ni 3 N showed higher oxidation current density, lower oxidation onset potential and higher stability compared with Ni/C. Li et al [32] . synthesized the NiCu/TiN catalyst by the electrochemical deposition method.…”