D-Penicillamine-induced Pemphigus Vulgaris in a Patient with Scleroderma-Rheumatoid Arthritis Overlap Syndrome

Szegedi, Andrea; Surányi, Péter; Szűcs, Gabriella; Kiss, Mária; Hunyadi, J.; Gaál, J

doi:10.1080/00015550410026399

Cited by 7 publications

(2 citation statements)

References 11 publications

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“…demonstrated the induction of acantholysis without antibody mediation ( 5 ). The main thiol containing PV inducing drugs include penicillamine, bucillamine, and captopril ( 6 , 7 , 9 , 10 , 12 , 14 , 16 , 18 – 20 , 22 , 53 ). Other known thiol drugs listed in Table 2 have been identified in isolated in case reports, longitudinal studies, and reviews ( 6 , 8 , 11 , 14 – 17 , 20 – 24 , 54 ).…”

Section: Findings On Environmental and Lifestyle “Exposome” Factorsmentioning

confidence: 99%

The multifactorial complexities of autoimmune development in Pemphigus vulgaris: Critical evaluation of the role of environmental and lifestyle “exposome” factors

et al. 2023

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Pemphigus vulgaris (PV) is a potentially life-threatening blistering disorder characterized by autoantibodies directed against cell-cell adhesion molecules that serves as an excellent model to study human autoimmune development. Numerous studies have identified specific Human Leukocyte Antigen (HLA) genes, in particular DRB1*0402 and DQB1*0503, that confer disease risk. Although HLA is required, it is not sufficient for the initiation of disease. As with all autoimmune diseases, the etio-pathogenesis of PV is complex, meaning it is multifactorial. Susceptibility is polygenic, and the search for non-HLA disease-linked genes continues. Moreover, twin studies across autoimmune conditions indicate that non-genetic environmental and lifestyle factors, which can be collectively grouped under the term “exposome”, are also major contributors to disease development. The literature presents evidence for the potential role of multiple triggers such as medications, infections, stress, diet, immunizations, and sleep to influence the etiology, pathophysiology, and prognosis of PV. However, a clear understanding of the degree to which specific factors impact PV is lacking. In this investigation, we comprehensively review the environmental elements listed above and consider the strength of evidence for these factors. The overall goals of this work are to provide greater insights into the factors that influence disease susceptibility, disease development and disease course and ultimately help to better guide clinicians and inform patients in the management of PV.

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Section: Findings On Environmental and Lifestyle “Exposome” Factorsmentioning

confidence: 99%

The multifactorial complexities of autoimmune development in Pemphigus vulgaris: Critical evaluation of the role of environmental and lifestyle “exposome” factors

et al. 2023

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“…Several reports have associated pemphigus with myasthenia gravis and thymoma, collagen autoimmune diseases such as systemic lupus erythematosus, Sjögren syndrome, rheumatoid arthritis, pernicious anemia, scleroderma, and thyroiditis. 41,[52][53][54][55][56] Pemphigus vulgaris was the most common variant. 42 It is unknown whether these diseases share with pemphigus a molecule that triggers an autoimmune response or whether the disease is the result of chronic exposure to an immunosuppressant or immunomodulator agent.…”

Section: Associations With Autoimmune Diseasesmentioning

confidence: 99%

Pemphigus

Chirinos-Saldaña

Navas

Ramírez-Miranda

et al. 2016

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Current awareness: Pharmacoepidemiology and drug safety

2004

Pharmacoepidemiology and Drug

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 20 sections: 1 Books, Reviews & Symposia; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Teratogens/fetal exposure; 20 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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D-Penicillamine-induced Pemphigus Vulgaris in a Patient with Scleroderma-Rheumatoid Arthritis Overlap Syndrome

Cited by 7 publications

References 11 publications

The multifactorial complexities of autoimmune development in Pemphigus vulgaris: Critical evaluation of the role of environmental and lifestyle “exposome” factors

The multifactorial complexities of autoimmune development in Pemphigus vulgaris: Critical evaluation of the role of environmental and lifestyle “exposome” factors

Pemphigus

Current awareness: Pharmacoepidemiology and drug safety

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