D-Pinitol prevents rat breast carcinogenesis induced by 7, 12 -Dimethylbenz [a] anthracene through inhibition of Bcl-2 and induction of p53, caspase-3 proteins and modulation of hepatic biotransformation enzymes and antioxidants

Rengarajan, Thamaraiselvan; Nandakumar, Natarajan; Balasubramanian, M.

doi:10.1016/j.bionut.2012.07.001

Cited by 16 publications

(4 citation statements)

References 54 publications

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“…Previous study suggests that antioxidant enzymes are critical in protecting against tumor-promoting agents. Interestingly, cell malignancy or transformation is often accompanied by a decrease in activity of antioxidant enzymes like SOD, CAT and GPx, which makes the cell sensitivity to carcinogen [55]. In this study, we observed decreased activities of enzymatic antioxidant such as SOD, CAT, GPx and non-enzymatic antioxidant GSH in DMBA alone treated animals [56].…”

Section: Discussionsupporting

confidence: 56%

Dose response chemopreventive potential of allyl isothiocyanate against 7,12-dimethylbenz(a)anthracene induced mammary carcinogenesis in female Sprague-Dawley rats

Rajakumar

Pugalendhi

Thilagavathi

2015

Chemico-Biological Interactions

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Section: Discussionsupporting

confidence: 56%

Dose response chemopreventive potential of allyl isothiocyanate against 7,12-dimethylbenz(a)anthracene induced mammary carcinogenesis in female Sprague-Dawley rats

Rajakumar

Pugalendhi

Thilagavathi

2015

Chemico-Biological Interactions

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“…The growth rate, parameter of body weight, of the MNU injected animals was declined when compared to control groups. This may be due to the changes in energy metabolism during tumor formation and in addition an increased level of MDA also plays an important role in the initiation of tumor development and in the decrease of body weight (Rengarajan et al, 2013). Also, the feed consumption efficiency was decreased in model control but not in different experimental test groups during study period was found to be unaltered.…”

Section: Discussionmentioning

confidence: 92%

“…Estrogen and Progesterone receptor expressions were quantified by immunohistochemistry (Parikh et al, 2005;Thordarson et al, 2001). The nucleic acids were extracted for measurement of DNA and RNA (Rengarajan et al, 2013).…”

Section: In-vivo Mnu Induced Mammary Carcinogenesismentioning

confidence: 99%

Chemoprevention of breast cancer by Psidium guajava Linn.

Karia¹,

Patil²,

Vakani³

et al. 2018

Asian J Pharm Pharmacol

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Breast cancer continues to be the most frequently occurring cancer in women around the world. For women, the three most commonly diagnosed cancers are breast, lung and bronchus, and colorectal. Representing one-half of all the cases; breast cancer alone is expected to account for 30% all new cancer diagnoses in women. An estimated 41,070 breast cancer deaths will occur in 2017 (Siegel et al., 2017). In India, it is the cancer of breast alone which is expected to cross the figure of 200000 by the year 2021 (Takiar et al., 2010). Based on the stage of diagnosis, breast cancer is treated with a multidisciplinary approach involving surgery, radiation and systemic therapy including chemotherapy or hormonal therapy (Harfindal and Helms, 2006). Surgery alone may increase the chances of relapse so combinations of chemotherapeutic agents are given. The side effects of chemotherapy depend on the individual, the drug used, the schedule and dose used. These side effects can include fatigue, risk of infection, nausea, vomiting, mouth sores, hair loss, anorexia, diarrhea and bone marrow suppression. Hormonal modifiers like Tamoxifen are given in estrogen

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“…Cancer incidence of the world and its mortality is associated with lifestyle and environmental agents like food and chemicals. Sustained exposure to chemicals directly or indirectly leads to increase cancer risk by participating in all aspects of carcinogenesis (1). Polycyclic aromatic hydrocarbons (PAHs) are xenobiotic compounds that are environmental contaminants.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the effect of watercress via nuclear factor-E2-related factor-2 pathway on 7,12-dimethylbenz[a]anthracene-induced oxidative damage in rat liver

Atay

Uyumlu

Satılmış

et al. 2021

Journal of Health Sciences and Medicine

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Aim: Nuclear factor E2-related factor-2 (Nrf2) regulates many cytoprotective antioxidants, and detoxifying enzymes, has been a hopeful approach for chemoprevention of cancer. We researched the chemopreventive impact of watercress on the DMBA-induced oxidative damage in the rat liver via the Nrf2/ARE signalling pathway in the present study. Material and Method: Female Wistar albino rats have categorized into three groups. The control was the first group, rats in the second and third groups were administered 7,12-dimethylbenz[a]anthracene (DMBA) (20 mg/kg b.w., i.p.) and rats in the third group were given daily doses of watercress (250 mg/kg b.w. Nasturtium officinale R.Br. for 4 weeks by oral gavage). Antioxidant and phase II detoxification enzyme activities, Nrf2 transcription factor level in liver, and serum ALT were determined. Also, histopathological analysis of the liver was performed. Results: We observed that watercress induces DNA-binding of Nrf2. It was related to increased enzyme activities of phase II detoxifying and the antioxidant. Our results also demonstrated that watercress ameliorated liver injury. Conclusion: Our data ensured considerable evidence that the dietary watercress ameliorates DMBA induced liver toxicity via regulating the activation of the Nrf2/ARE pathway which increases the expression of cytoprotective enzymes.

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D-Pinitol prevents rat breast carcinogenesis induced by 7, 12 -Dimethylbenz [a] anthracene through inhibition of Bcl-2 and induction of p53, caspase-3 proteins and modulation of hepatic biotransformation enzymes and antioxidants

Cited by 16 publications

References 54 publications

Dose response chemopreventive potential of allyl isothiocyanate against 7,12-dimethylbenz(a)anthracene induced mammary carcinogenesis in female Sprague-Dawley rats

Dose response chemopreventive potential of allyl isothiocyanate against 7,12-dimethylbenz(a)anthracene induced mammary carcinogenesis in female Sprague-Dawley rats

Chemoprevention of breast cancer by Psidium guajava Linn.

Investigation of the effect of watercress via nuclear factor-E2-related factor-2 pathway on 7,12-dimethylbenz[a]anthracene-induced oxidative damage in rat liver

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