d-ribose improves cardiac contractility and hemodynamics, and reduces expression of c-fos in the hippocampus during sustained slow ventricular tachycardia in rats

Modulation of intracellular ATP determines adenosine release and functional outcome in response to metabolic stress in rat hippocampal slices and cerebellar granule cells

“…; Schneider et al . ), and may also provide benefit in renal ischaemic injury (Nishiyama et al . ; Sato et al .…”

“…Indeed, the positive effects of Rib or Rib and Ade on the recovery of post-ischaemic myocardial ATP and TAN in in vitro and in vivo preparations are well documented (Zimmer 1982(Zimmer , 1996Mauser et al 1985;St Cyr et al 1986;Zimmer et al 1989;Muller et al 1998;Smolenski et al 1998;Perkowski et al 2007). Furthermore, improved postischaemic ATP recovery has been linked to an enhanced functional recovery of the heart, as seen in improved cardiac contractility (Pasque and Wechsler 1984;Lamberts et al 2007;Schneider et al 2008), and may also provide benefit in renal ischaemic injury (Nishiyama et al 2009;Sato et al 2009). In humans, administration of Rib to patients suffering from congestive heart failure (Pliml et al 1992;Omran et al 2003Omran et al , 2004MacCarter et al 2009) has been shown to have beneficial effects on cardiac function, likely via improved cardiac energy metabolism, which has led to suggestions that Rib should be used therapeutically (Pauly and Pepine 2000;Shecterle et al 2010).…”

Protective Action of D-Ribose against Renal Injury Caused by Ischemia and Reperfusion in Rats with Transient Hyperglycemia

“…D-ribose administration did not result in significant changes in blood glucose when compared with control group rats. Schneider et al reported that D-ribose improved hemodynamic parameters and prevented the activation of pro-apoptotic c-fos during ventricular tachycardia with 450 mg/kg of D-ribose in rats (Schneider et al 2008). Meanwhile, in previous report regarding the metabolism of D-ribose in man, a marked reduction in blood glucose concentration occurred after 20 and 10 gram of D-ribose infusion, presumably by inhibiting the enzyme phosphoglucomutase (Segal and Foley 1958).…”