D-ribose-L-cysteine improves hormonal imbalance, spermatogenic dysregulation, and redox status in streptozotocin-diabetic rats

Ukwenya, Victor Okoliko; Olawuyi, Toluwase Solomon; Adelakun, Sunday Aderemi; Ogunsola, Oluwole Israel; Ukwenya, Moses U.

doi:10.1007/s00580-020-03155-3

Cited by 13 publications

(3 citation statements)

References 26 publications

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“…Lafuente et al (2001) had suggested that the observed reduction in testicular function may be due to STZ toxicity on the hypothalamic-pituitary-gonadal axis. In agreement with previous reports (Abdolahnejad et al, 2009;Long et al, 2015;Ukwenya et al,2020), the present study revealed that the group treated with STZ showed that the seminiferous tubules degenerated and were atrophied, the germinal epithelium was vacuolated and there was absence of late germ cells. There was low testicular weight, also degeneration of spermatogenic cells and absence of sperm bundles.…”

Section: Discussionsupporting

confidence: 93%

Morphological and Biochemical Evaluation of the Testes of Hyperglycemic Guinea Pigs Treated with Cyperus Esculentus Extract

Akunna,

S.,

Wali

et al. 2023

JIMR

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In this study, we aimed to evaluate the effects of Cyperus esculentus extract on Testicular Morphology and Biochemistry post streptozotocin-treatment in Male Guinea Pigs. Twenty guinea pigs were divided into four groups containing five pigs each. Group A served as the negative control was treated with 5ml/kg body weight of normal saline orally, Group B were treated with a single dose of 65mg/kg body weight of streptozotocin (STZ) intraperitoneally, Group C were treated with a single dose of 65mg/kg body weight of STZ and daily treatment with 150mg/kg of CEE orally and Group D were treated with a single dose of 65mg/kg body weight of STZ and daily treatment with 150mg/kg of CEE orally for 20days. Morphological scores and biochemical evaluation were done. Results showed a significant decrease in testicular weight, number of spematogonia, Leydig cells and Sertoli cells, levels of SOD and CAT as well as a significant increase in the level of MDA after the administration of STZ alone when compared to the control. A significant decrease in the levels of testosterone and FSH as well as a decrease in the level of LH was observed in group B when compared to the control. However, the groups that were co-treated with the extract had a better parameters and histological profiles when compared to the positive control group. CEE has a dose-dependent ameliorative effect on STZ-induced testicular hormonal, oxidative and histomorphometric degeneration.

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Section: Discussionsupporting

confidence: 93%

Morphological and Biochemical Evaluation of the Testes of Hyperglycemic Guinea Pigs Treated with Cyperus Esculentus Extract

Akunna,

S.,

Wali

et al. 2023

JIMR

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“…Cisplatin also, suppresses the activity of antioxidant enzymes (GSH, SOD and CAT) and increases free radical levels (hydrogen peroxide and lipid peroxide) in the testes [ 45 ], all these processes are factors which are prerequisite to testicular degeneration. The therapeutic potential of D- Ribose- l -Cysteine (DRLC) in CN induced testicular degeneration was tested in this study, DRLC is the active ingredient in riboceine; one of the synthetic antioxidants that helps cell produce glutathione (GSH) on demand [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Ameliorating potential and fertility enhancing activities of nutritional dietary supplementation of D-Ribose –l-Cysteine in cisplatin induced oligoasthenoteratozoospermia and seminiferous epithelium degeneration in adult male Sprague-Dawley rats

et al. 2021

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Background Cisplatin (CN) is considered as a cytotoxic agent and DNA synthesis inhibitor. D-Ribose- l -Cysteine (DRLC) is an active ingredient of riboceine, help cells to produce glutathione on body demand. Aim Current study focused on ameliorating potential and fertility enhancing activities of D-Ribose– l -Cysteine in cisplatin induced oligoasthenoteratozoospermia and seminiferous epithelium degeneration. Materials and method Sixty (60) male rats randomized into six groups of ten (n = 10) rats each. Group A (control) received 2.0 ml distilled water, group B received single dose of 8 mg/kg bwt CN, group C received 30 mg/kg bwt DRLC, group D received single dose of 8 mg/kg CN follow by 30 mg/kg bwt DRLC, group E received single dose of 8 mg/kg CN and vitamin C, group F received single dose of 8 mg/kg cisplatin follow by DRLC + Vit.C for 56 days. Parameters tested include: Sperm parameters, testosterone (TT), luteinizing hormone (LH), Follicle stimulating Hormone, (FSH), Prolactin, and testicular 17β-HSD activity, Blood hydroperoxide (BHP), Malondialdehyde (MDA), Superoxide Dismutase (SOD), Glutathione (GSH) and Catalase (CAT), testicular histology and fertility test. Results Cisplatin significantly reduced testicular volume, body weight, sperm quality, fertility indices, TT, FSH, LH, 17β-HSD, SOD, GSH, CAT, diameter and cross-sectional area of seminiferous tubules, spermatogenesis score. And elevate prolactin, testicular injury score, BHP and MDA compared with control group. Cisplatin only treated rats showed degenerated seminiferous epithelium with empty lumen. Intervention of D-Ribose-Cysteine ameliorated toxic impacts of CN on testis and improved the male fertility. Conclusion D-Ribose- l -Cysteine therefore, preserves testicular integrity and functions thereby, preventing the deleterious impact of CN.

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“…Histological analyses of the ovary and the uterus were assessed from 5 μm sections of paraffin-embedded tissues following hematoxylin-eosin staining [ [61] , [62] , [63] ]. Histomorphological changes were assessed on microphotographs using a Scientico STM-50 microscope equipped with a Celestron MA411101 camera connected to a computer where the image was transferred and analyzed with the Image J1.3 software.…”

Section: Methodsmentioning

confidence: 99%

Therapeutic effects of aqueous extract of bioactive active component of Ageratum conyzoides on the ovarian-uterine and hypophysis-gonadal axis in rat with polycystic ovary syndrome: Histomorphometric evaluation and biochemical assessment

et al. 2022

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D-ribose-L-cysteine improves hormonal imbalance, spermatogenic dysregulation, and redox status in streptozotocin-diabetic rats

Cited by 13 publications

References 26 publications

Morphological and Biochemical Evaluation of the Testes of Hyperglycemic Guinea Pigs Treated with Cyperus Esculentus Extract

Morphological and Biochemical Evaluation of the Testes of Hyperglycemic Guinea Pigs Treated with Cyperus Esculentus Extract

Ameliorating potential and fertility enhancing activities of nutritional dietary supplementation of D-Ribose –l-Cysteine in cisplatin induced oligoasthenoteratozoospermia and seminiferous epithelium degeneration in adult male Sprague-Dawley rats

Therapeutic effects of aqueous extract of bioactive active component of Ageratum conyzoides on the ovarian-uterine and hypophysis-gonadal axis in rat with polycystic ovary syndrome: Histomorphometric evaluation and biochemical assessment

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