D<sub>1</sub> and D<sub>2</sub> receptor‐mediated dopaminergic modulation of visual responses in cat dorsal lateral geniculate nucleus

Zhao, Yongqiang; Kerscher, Nicolas; Eysel, Ulf T.; Funke, Klaus

doi:10.1113/jphysiol.2001.012721

Cited by 33 publications

(28 citation statements)

References 42 publications

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“…Moreover, D 2 -like dopamine receptor binding sites have been shown in the human thalamus using in vivo radioligands, with a distribution that resembles that of the dopamine innervation described here (Rieck et al, 2004). Finally, dopamine and D 1 -like and D 2 -like dopamine receptor agonists modulate visual responses of the cat dorsal lateral geniculate thalamic nucleus (Zhao et al, 2001(Zhao et al, , 2002). …”

Section: Discussionmentioning

confidence: 78%

The Primate Thalamus Is a Key Target for Brain Dopamine

Sánchez-González

García‐Cabezas²,

Rico³

et al. 2005

J. Neurosci.

283

187

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The thalamus relays information to the cerebral cortex from subcortical centers or other cortices; in addition, it projects to the striatum and amygdala. The thalamic relay function is subject to modulation, so the flow of information to the target regions may change depending on behavioral demands. Modulation of thalamic relay by dopamine is not currently acknowledged, perhaps because dopamine innervation is reportedly scant in the rodent thalamus. We show that dopaminergic axons profusely target the human and macaque monkey thalamus using immunolabeling with three markers of the dopaminergic phenotype (tyrosine hydroxylase, dopamine, and the dopamine transporter). The dopamine innervation is especially prominent in specific association, limbic, and motor thalamic nuclei, where the densities of dopaminergic axons are as high as or higher than in the cortical area with the densest dopamine innervation. We also identified the dopaminergic neurons projecting to the macaque thalamus using retrograde tract-tracing combined with immunohistochemistry. The origin of thalamic dopamine is multiple, and thus more complex, than in any other dopaminergic system defined to date: dopaminergic neurons of the hypothalamus, periaqueductal gray matter, ventral mesencephalon, and the lateral parabrachial nucleus project bilaterally to the monkey thalamus. We propose a novel dopaminergic system that targets the primate thalamus and is independent from the previously defined nigrostriatal, mesocortical, and mesolimbic dopaminergic systems. Investigating this "thalamic dopaminergic system" should further our understanding of higher brain functions and conditions such as Parkinson's disease, schizophrenia, and drug addiction.

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Section: Discussionmentioning

confidence: 78%

The Primate Thalamus Is a Key Target for Brain Dopamine

Sánchez-González

García‐Cabezas²,

Rico³

et al. 2005

J. Neurosci.

283

187

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“…This implies that conversely, depletion of these neuromodulators may lead to slow synchronous rhythms in the LGN. More recently, Zhao et al (2002) have shown that dopaminergic neuro-receptors affect information transmission efficiency in the LGN by neuromodulation of the IN cells. Furthermore, their study suggest a stronger suppression of the TCR cells with blockage of GABA A neuro-receptors.…”

Section: Resultsmentioning

confidence: 99%

“…This condition simulates the blocking of GABA-ergic feed-forward inhibition of the TCR due to neuromodulatory effects on the IN by several neurotransmitters such as acetylcholine (McCormick, 1992) and dopamine (Zhao et al, 2002). The time series output of both TCR and TRN in Figure 4A shows a distinct bifurcation with synchronized waxing-and-waning of amplitude within the alpha band frequency.…”

Section: Resultsmentioning

confidence: 99%

“…Based on some preliminary results in Bond et al (2014), our hypothesis in this work has been to understand possible underlying neuro-pathological changes that may “block” the IN inhibitory effects on the TCR cells, which may lead to state transitions in the LGN corresponding to both normal and pathological conditions. Indeed, experimental studies have shown the neuromodulatory effects of acetylcholine, noradrenaline (McCormick, 1992) and dopamine (Zhao et al, 2002) on the LGN that seem to “regulate” (under normal conditions) or affect (under abnormal pathological conditions) its synaptic efficacy and oscillatory patterns; specifically, dopamine has been implicated in affecting information transmission in the LGN by neuromodulation of IN. In this work, we have simulated the effects on neuromodulation by varying the neurotransmitter concentration in the synaptic clefts.…”

Section: Discussionmentioning

confidence: 99%

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Causal Role of Thalamic Interneurons in Brain State Transitions: A Study Using a Neural Mass Model Implementing Synaptic Kinetics

Bhattacharya

Bond

O’Hare

et al. 2016

Front. Comput. Neurosci.

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Experimental studies on the Lateral Geniculate Nucleus (LGN) of mammals and rodents show that the inhibitory interneurons (IN) receive around 47.1% of their afferents from the retinal spiking neurons, and constitute around 20–25% of the LGN cell population. However, there is a definite gap in knowledge about the role and impact of IN on thalamocortical dynamics in both experimental and model-based research. We use a neural mass computational model of the LGN with three neural populations viz. IN, thalamocortical relay (TCR), thalamic reticular nucleus (TRN), to study the causality of IN on LGN oscillations and state-transitions. The synaptic information transmission in the model is implemented with kinetic modeling, facilitating the linking of low-level cellular attributes with high-level population dynamics. The model is parameterized and tuned to simulate alpha (8–13 Hz) rhythm that is dominant in both Local Field Potential (LFP) of LGN and electroencephalogram (EEG) of visual cortex in an awake resting state with eyes closed. The results show that: First, the response of the TRN is suppressed in the presence of IN in the circuit; disconnecting the IN from the circuit effects a dramatic change in the model output, displaying high amplitude synchronous oscillations within the alpha band in both TCR and TRN. These observations conform to experimental reports implicating the IN as the primary inhibitory modulator of LGN dynamics in a cognitive state, and that reduced cognition is achieved by suppressing the TRN response. Second, the model validates steady state visually evoked potential response in humans corresponding to periodic input stimuli; however, when the IN is disconnected from the circuit, the output power spectra do not reflect the input frequency. This agrees with experimental reports underpinning the role of IN in efficient retino-geniculate information transmission. Third, a smooth transition from alpha to theta band is observed by progressive decrease of neurotransmitter concentrations in the synaptic clefts; however, the transition is abrupt with removal of the IN circuitry in the model. The results imply a role of IN toward maintaining homeostasis in the LGN by suppressing any instability that may arise due to anomalous synaptic attributes.

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“…However, the role of dopamine in the regulation of sleep-related activity in the thalamus is unclear. It was suggested, that dopamine acts by indirectly inhibiting relay cell activity through the excitation of local interneurons [3,196]. Indeed, dopamine modulates the inhibitory synaptic transmission to dLGN TC neurons by activation of D 2 -like receptors on local GABAergic interneurons [123].…”

Section: Thalamic Interneurons and Dopaminementioning

confidence: 99%

The sleep relay—the role of the thalamus in central and decentral sleep regulation

Coulon

Budde

Pape

2011

Pflugers Arch - Eur J Physiol

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Surprisingly, the concept of sleep, its necessity and function, the mechanisms of action, and its elicitors are far from being completely understood. A key to sleep function is to determine how and when sleep is induced. The aim of this review is to merge the classical concepts of central sleep regulation by the brainstem and hypothalamus with the recent findings on decentral sleep regulation in local neuronal assemblies and sleep regulatory substances that create a scenario in which sleep is both local and use dependent. The interface between these concepts is provided by thalamic cellular and network mechanisms that support rhythmogenesis of sleep-related activity. The brainstem and the hypothalamus centrally set the pace for sleep-related activity throughout the brain. Decentral regulation of the sleep-wake cycle was shown in the cortex, and the homeostat of non-rapid-eye-movement sleep is made up by molecular networks of sleep regulatory substances, allowing individual neurons or small neuronal assemblies to enter sleep-like states. Thalamic neurons provide state-dependent gating of sensory information via their ability to produce different patterns of electrogenic activity during wakefulness and sleep. Many mechanisms of sleep homeostasis or sleep-like states of neuronal assemblies, e.g. by the action of adenosine, can also be found in thalamic neurons, and we summarize cellular and network mechanisms of the thalamus that may elicit non-REM sleep. It is argued that both central and decentral regulators ultimately target the thalamus to induce global sleep-related oscillatory activity. We propose that future studies should integrate ideas of central, decentral, and thalamic sleep generation.

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D₁ and D₂ receptor‐mediated dopaminergic modulation of visual responses in cat dorsal lateral geniculate nucleus

Cited by 33 publications

References 42 publications

The Primate Thalamus Is a Key Target for Brain Dopamine

The Primate Thalamus Is a Key Target for Brain Dopamine

Causal Role of Thalamic Interneurons in Brain State Transitions: A Study Using a Neural Mass Model Implementing Synaptic Kinetics

The sleep relay—the role of the thalamus in central and decentral sleep regulation

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D1 and D2 receptor‐mediated dopaminergic modulation of visual responses in cat dorsal lateral geniculate nucleus

Cited by 33 publications

References 42 publications

The Primate Thalamus Is a Key Target for Brain Dopamine

The Primate Thalamus Is a Key Target for Brain Dopamine

Causal Role of Thalamic Interneurons in Brain State Transitions: A Study Using a Neural Mass Model Implementing Synaptic Kinetics

The sleep relay—the role of the thalamus in central and decentral sleep regulation

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D₁ and D₂ receptor‐mediated dopaminergic modulation of visual responses in cat dorsal lateral geniculate nucleus