2009
DOI: 10.1523/jneurosci.4746-08.2009
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D1/D5Modulation of Synaptic NMDA Receptor Currents

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Cited by 48 publications
(36 citation statements)
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References 70 publications
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“…Likewise, the signaling events leading to SFK-induced phosphorylation of NMDAR subunits, downstream of GPCRs activation, might be complex and also context-dependent in different neuronal populations. For instance, activation of the D 1 R/AC/PKA pathway in single CA1 neurons shows opposing effects on D 1 R-regulated NMDAR functioning, which is claimed to depend on NMDAR receptor localization and subunit composition65. Our observation that D 1 R activation was associated with a decrease of NMDAR-dependent currents in retinal neurons is consistent with Csk activation, Src inhibition and reduced GluN2B phosphorylation in neurites.…”
Section: Discussionsupporting
confidence: 77%
“…Likewise, the signaling events leading to SFK-induced phosphorylation of NMDAR subunits, downstream of GPCRs activation, might be complex and also context-dependent in different neuronal populations. For instance, activation of the D 1 R/AC/PKA pathway in single CA1 neurons shows opposing effects on D 1 R-regulated NMDAR functioning, which is claimed to depend on NMDAR receptor localization and subunit composition65. Our observation that D 1 R activation was associated with a decrease of NMDAR-dependent currents in retinal neurons is consistent with Csk activation, Src inhibition and reduced GluN2B phosphorylation in neurites.…”
Section: Discussionsupporting
confidence: 77%
“…Induction of the PKC signaling pathway following NMDAR activation has been widely demonstrated in the CNS [22,61,66]. In DRG neurons, activation of NMDARs enhances the activity of voltage dependent Ca 2+ channels through PKC [11,39].…”
Section: Discussionmentioning
confidence: 99%
“…Kim et al have provided strong evidence that acute ifenprodil treatment increased GluR1-containing AMPA receptors (AMPARs) [42], and further study demonstrated that Ras was implicated in synaptic delivery of GluR1-containing AMPARs [43]. Moreover, other studies demonstrated that D1R potentiated glutamate-mediated Ca 2+ influx and synaptic responses through GluN2B-containing NMDARs [44,45]. Hence, the underlying reason for the increase level of Ras might be interference from DRs and AMPARs and their downstream signaling pathways at these doses.…”
Section: Effect Of Ifenprodil On Meth-induced Behavioral Sensitizatiomentioning
confidence: 99%