In this study, it was aimed to understand how operating in the operating room is from the perspective of the operating room nurses Methods: The study was conducted with qualitative research method, using a semi-structured interview form with nine voluntary operating nurses working in a training and research hospital between December 2018 and January 2019, with indepth interviews with each participant that lasted about thirty minutes. During the interviews, sound recordings were kept with prior permission, and the data obtained were analysed using the NVivo 10 program. Results: According to the results obtained from the study, the statements of the nurses were collected under five sub-themes. These; The negative aspects of working in the operating room, the positive aspects of operating the operating room, the effect of professional skills on daily life, professional future and expectations. These themes were later categorized. These; six categories on the theme of the negative aspects of working in the operating room; four categories on the theme of indoor environment, socialism, malnutrition, inability to participate in vocational training, silence, risks, positive aspects of working in the operating room; four categories on the theme of stress management, self-worth, personal development, being away from the relationship with the patient / patient relatives, the effect of professional skills on daily life; three categories on the theme of normalization, empathy, desensitization, self-identification, professional future; five categories in terms of professional development, pursuing a different profession, not being able to plan a career, expectations; physical environment, communication, security, motivation, number of employees. Conclusion: Working in the operating room has many benefits for nurses; On the other hand, it was concluded that the negativities caused by working in the operating room should be considered as a risk for employee and patient safety.