d-Xylose suppresses adipogenesis and regulates lipid metabolism genes in high-fat diet–induced obese mice

Lim, Eunhee; Lim, Ji Ye; Shin, Jae Ho; Seok, Pu Reum; Jung, Sangwon; Yoo, Sangjun; Kim, Yuri

doi:10.1016/j.nutres.2015.05.012

Cited by 39 publications

(32 citation statements)

References 60 publications

(66 reference statements)

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“…This was supported by the fact that PPARα, ACO and CPT I all play a crucial role in FAs oxidation, which provides energy for peripheral tissues (Lefebvre, Chinetti, Fruchart, & Staels, ; Rigamonti, Chinetti‐Gbaguidi, & Staels, ). Generally, when an animal is in a lipid‐overloaded state, and lipids are metabolically dysregulated, the β‐oxidation of fatty acids in peroxisomal, mitochondrial and microsomal is usually suppressed, thus leading to hepatic steatosis (Lim et al., ). Taken together, these results might imply that XOS supplementation inhibits hepatic fat accumulation by regulating mitochondrial, peroxisomal and microsomal fatty acid oxidation.…”

Section: Discussionmentioning

confidence: 99%

“…This was supported by the facts that (i) LPL, being the rate‐limiting enzyme for the hydrolysis of core triglycerides, promotes the cellular uptake of cholesterol‐rich lipoproteins and free fatty acids (Nilsson‐Ehle, Garfinkel, & Schotz, ) and (ii) CD36 regulates protein whose expression is modulated by conditions that alter lipid metabolism (Brinkmann, Abumrad, Ibrahimi, Vandervusse, & Glatz, ). Generally, the up‐regulation of LPL and the down‐regulation of CD36 could lead to steatosis (Lim et al., ). In fact, the increase in CD36 mRNA levels observed in this study was associated with the decreased plasma levels of NEFAs, TG, TC and LDL, as well as the increased HDL levels of fish fed HFD supplemented with 10 g/kg and 20 g/kg XOS which were similar to those fed the control diet.…”

Section: Discussionmentioning

confidence: 99%

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Dietary supplementation of xylooligosaccharides benefits the growth performance and lipid metabolism of common carp (Cyprinus carpio) fed high-fat diets

Abasubong

Zhang

et al. 2018

Aquacult Nutr

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We aimed to investigate the effect of xylooligosaccharides (XOS) on the growth performances and lipid metabolism of common carp fed high‐fat diets. 192 fish were randomly distributed into 24 tanks into six groups (four replicates) and were fed with control diet, high‐fat diet (HFD) and HFD supplemented with 5, 10, 20 and 30 g/kgXOS respectively for 8 weeks. Fish fed HFD supplemented with 10 g/kg XOS obtained higher final body weight, weight gain, specific growth rate and protein efficiency ratio compared to those fed control diet and HFD, while feed conversion ratio showed the opposite trend. Fish fed HFD obtained higher hepatosomatic index, abdominal fat, energy intake compared to other groups, whereas the opposite was true for nitrogen retention. High plasma levels of cholesterol, triglycerides, low‐density lipoprotein and low high‐density lipoprotein were observed in fish fed HFD; opposite was true for fish fed HFD supplemented with 10–20 g/kg XOS. The transcription of lipoprotein lipase was up‐regulated, whereas that of carnitine palmitoyltransferase I, peroxisome proliferator‐activated receptors alpha, acyl‐CoA oxidase and CD36 were down‐regulated in fish fed HFD. Opposite trend was observed in fish fed HFD supplemented with 10–20 g/kg XOS as well as the control group. In conclusion, XOS inclusion can benefit the growth performance and lipid metabolism of common carp fed HFD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Dietary supplementation of xylooligosaccharides benefits the growth performance and lipid metabolism of common carp (Cyprinus carpio) fed high-fat diets

Abasubong

Zhang

et al. 2018

Aquacult Nutr

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“…d -Xylose is a natural pentose and a potent sucrose inhibitor [44]. A recent study showed that the administration of 5% or 10% d -xylose in sucrose mixtures significantly lowered blood glucose levels in humans [45].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, administration of 10% d -xylose in a sucrose solution significantly reduced under the glucose curve (AUCg) values and under the insulin curve (AUCi) values obtained from OGTTs performed for healthy individuals [46]. Improved lipid metabolism in serum and gene expression in adipose and liver tissues following administration of D-xylose have also been investigated in an animal model [44]. …”

Section: Discussionmentioning

confidence: 99%

Xylobiose, an Alternative Sweetener, Ameliorates Diabetes-Related Metabolic Changes by Regulating Hepatic Lipogenesis and miR-122a/33a in db/db Mice

Lim

Kim

et al. 2016

Nutrients

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Type 2 diabetes is a major public health concern worldwide. Xylobiose (XB) consists of two molecules of d-xylose and is a major disaccharide in xylooligosaccharides that are used as prebiotics. We hypothesized that XB could regulate diabetes-related metabolic and genetic changes via microRNA expression in db/db mice. For six weeks, C57BL/KsJ-db/db mice received 5% XB as part of the total sucrose content of their diet. XB supplementation improved glucose tolerance with reduced levels of OGTT AUC, fasting blood glucose, HbA1c, insulin, and HOMA-IR. Furthermore, XB supplementation decreased the levels of total triglycerides, total cholesterol, and LDL-C. The expression levels of miR-122a and miR-33a were higher and lower in the XB group, respectively. In the liver, expressions of the lipogenic genes, including, fatty acid synthase (FAS), peroxisome proliferator activated receptor γ (PPARγ), sterol regulatory element-binding protein-1C (SREBP-1C), sterol regulatory element-binding protein-2 (SREBP-2), acetyl-CoA carboxylase (ACC), HMG-CoA reductase (HMGCR), ATP-binding cassette transporter G5/G8 (ABCG5/8), cholesterol 7 alpha-hydroxylase (CYP7A1), and sterol 12-alpha-hydroxylase (CYP8B1), as well as oxidative stress markers, including superoxide dismutase 1 (SOD1), superoxide dismutase 2 (SOD2), glutathione peroxidase (GPX), and catalase, were also regulated by XB supplementation. XB supplementation inhibited the mRNA expressions levels of the pro-inflammatory cytokines, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, interleukin (IL)-6, and monocyte chemoattractant protein (MCP)-1, as well as phosphorylation of c-Jun N-terminal kinase/stress activated protein kinase (JNK/SAPK), p38 mitogen-activated protein kinases (MAPK), and extracellular signal-regulated kinases 1/2 (ERK1/2). These data demonstrate that XB exhibits anti-diabetic, hypolipogenic, and anti-inflammatory effects via regulation of the miR-122a/33a axis in db/db mice.

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“…Thus, it becomes the 'nondigestible' (ND) dietary carbohydrate substrates (Cummings and Macfarlane, 1991). It has been reported that d-xylose is beneficial for the alleviation of adipogenesis and dyslipidemia in obese mice (Lim et al, 2015), and it is difficult to be digested by species of bacteria from the human colon (Louis et al, 2007). Xylose can be used as a substitute for table sugar for obesity patients.…”

Section: Introductionmentioning

confidence: 99%

Enhanced enzymatic hydrolysis of sugarcane bagasse hemicellulose using recombinant glucose oxidase expressed by Pichia pastoris

Yang

Zhang

Yan

et al. 2015

Industrial Crops and Products

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d-Xylose suppresses adipogenesis and regulates lipid metabolism genes in high-fat diet–induced obese mice

Cited by 39 publications

References 60 publications

Dietary supplementation of xylooligosaccharides benefits the growth performance and lipid metabolism of common carp (Cyprinus carpio) fed high-fat diets

Dietary supplementation of xylooligosaccharides benefits the growth performance and lipid metabolism of common carp (Cyprinus carpio) fed high-fat diets

Xylobiose, an Alternative Sweetener, Ameliorates Diabetes-Related Metabolic Changes by Regulating Hepatic Lipogenesis and miR-122a/33a in db/db Mice

Enhanced enzymatic hydrolysis of sugarcane bagasse hemicellulose using recombinant glucose oxidase expressed by Pichia pastoris

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