D2-receptor imaging with [123I]IBZM and Single Photon Emission Tomography in psychiatry: a survey of current status

Abstract

D2-dopamine receptors can be visualized in the human brain in vivo by Single Photon Emission Tomography (SPECT) and the radiolabeled benzamide [123I]IBZM. The present paper reviews the current status of this type of functional brain imaging with respect to basic methodological aspects, data analysis and quantification. The results from published clinical studies in different psychiatric patient populations and normal controls with [123I]IBZM are reviewed. [123I]IBZM-SPECT is a powerful tool for the investigation of D2-dopamine receptor status in psychiatric disorders, different types of drug treatment as well as therapeutic and side effects of pharmacologic agents. However, there still is a need for standardized imaging times and image-processing procedures. Advantages and disadvantages of SPECT with special regard to Positron Emission Tomography (PET) are also discussed.

Task‐based design of a synthetic‐collimator SPECT system used for small animal imaging

“…as well as for its high-specific activity ( > 1850 GBq/lmol) to avoid mass effects and limit radiation dose. 12,13 One major advantage of using 123 I is that it emits photons at various energies which allowed us to utilize the multienergy approach described before, with the silicon detector (Si), placed in front, being sensitive to the $ 30 keV photons and the germanium detector (Ge), in the back, being sensitive to the 159 keV photons. 10 The relative abundances of photons at these two energy ranges are relatively similar; however, the exact values were not modeled in our simulations.…”

“…123 I was chosen due of its common presence in radiotracers which target dopamine receptors (IZBM, etc.) as well as for its high specific activity (> 1850 GBq/ μ mol) to avoid mass effects and limit radiation dose [12][13]. One major advantage of using 123 I is that it emits photons at various energies which allowed us to utilize the multi-energy approach described before, with the silicon detector (Si), placed in front, being sensitive to the ~30keV photons and the germanium detector (Ge), in the back, being sensitive to the 159keV photons[10].…”