Dabigatran for Mechanical Valves

Howard, Patricia A.

doi:10.1310/hpj4904-334

Cited by 1 publication

(2 citation statements)

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“…Alternatively, mechanical valves have a lifelong durability, but their application requires an anticoagulation therapy. 2 Similar shortcomings are related to other cardiovascular implants and devices made of many types of biomaterials. 3−5 The composition and conformational changes of adsorbed proteins are considered to be one of the most crucial factors affecting further blood-material interactions.…”

Section: Introductionmentioning

confidence: 80%

“…Bioprosthetic valves are used as a standard prosthesis to treat heart valve disorders, although their durability is a significant drawback. Alternatively, mechanical valves have a lifelong durability, but their application requires an anticoagulation therapy . Similar shortcomings are related to other cardiovascular implants and devices made of many types of biomaterials. − The composition and conformational changes of adsorbed proteins are considered to be one of the most crucial factors affecting further blood-material interactions. − An understanding of the thrombus formation process at the surface of implants is crucial for the development and design of novel hemocompatible materials.…”

Section: Introductionmentioning

confidence: 99%

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Rolling or Two-Stage Aggregation of Platelets on the Surface of Thin Ceramic Coatings under in Vitro Simulated Blood Flow Conditions

Mzyk

Imbir

Trembecka-Wójciga

et al. 2020

ACS Biomater. Sci. Eng.

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The process of modern cardiovascular device fabrication should always be associated with an investigation of how surface properties modulate its hemocompatibility through plasma protein adsorption as well as blood morphotic element activation and adhesion. In this work, a package of novel assays was used to correlate the physicochemical properties of thin ceramic coatings with hemocompatibility under dynamic conditions. Different variants of carbon-based films were prepared on polymer substrates using the magnetron sputtering method. The microstructural, mechanical, and surface physicochemical tests were performed to characterize the coatings, followed by investigation of whole human blood quality changes under blood flow conditions using the “Impact R” test, tubes’ tester, and radial flow chamber assay. The applied methodology allowed us to determine that aggregate formation on hydrophobic and hydrophilic carbon-based coatings may follow one of the two different mechanisms dependent on the type and conformational changes of adsorbed blood plasma proteins.

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Section: Introductionmentioning

confidence: 80%