Purpose
Magnetic resonance (MR) imaging with a long scan time can lead to degraded images due to patient motion, patient discomfort, and increased costs. For these reasons, the role of rapid MR imaging is important. In this study, we propose the joint reconstruction of multicontrast brain MR images from downâsampled data to accelerate the data acquisition process using a novel deepâlearning network.
Methods
Twentyâone healthy volunteers (female/male = 7/14, age = 26 ± 4 yr, range 22â35 yr) and 16 postoperative patients (female/male = 7/9, age = 49 ± 9 yr, range 37â62 yr) were scanned on a 3T wholeâbody scanner for prospective and retrospective studies, respectively, using both T1âweighted spinâecho (SE) and T2âweighted fast spinâecho (FSE) sequences. We proposed a network which we term âXânetâ to reconstruct both T1â and T2âweighted images from downâsampled images as well as a network termed âYânetâ which reconstructs T2âweighted images from highly downâsampled T2âweighted images and fully sampled T1âweighted images. Both Xânet and Yânet are composed of two concatenated subnetworks. We investigate optimal sampling patterns, the optimal patch size for augmentation, and the optimal acceleration factors for network training. An additional Yânet combined with a generative adversarial network (GAN) was also implemented and tested to investigate the effects of the GAN on the Yânet performance. Singleâ and jointâreconstruction parallelâimaging and compressedâsensing algorithms along with a conventional Uânet were also tested and compared with the proposed networks. For this comparison, the structural similarity (SSIM), normalized mean square error (NMSE), and FrĂ©chet inception distance (FID) were calculated between the outputs of the networks and fully sampled images. The statistical significance of the performance was evaluated by assessing the interclass correlation and in paired tâtests.
Results
The outputs from the two concatenated subnetworks were closer to the fully sampled images compared to those from one subnetwork, with this result showing statistical significance. Uniform downâsampling led to a statically significant improvement in the image quality compared to random or central downâsampling patterns. In addition, the proposed networks provided higher SSIM and NMSE values than Uânet, compressedâsensing, and parallelâimaging algorithms, all at statistically significant levels. The GANâbased Yânet showed a better FID and more realistic images compared to a nonâGANâbased Yânet. The performance capabilities of the networks were similar between normal subjects and patients.
Conclusions
The proposed Xânet and Yânet effectively reconstructed full images from downâsampled images, outperforming the conventional parallelâimaging, compressedâsensing and Uânet methods and providing more realistic images in combination with a GAN. The developed networks potentially enable us to accelerate multicontrast anatomical MR imaging in routine clinical studies including T1âand T2âweighted imaging.