Daidzein derivative daid002 inhibits glioblastoma growth via disrupting the interaction between moesin and CD44

Zhang, Xin; Liu, Xiuting; Zhang, Jinghui; Zhou, Wei; Lu, Jinrong; Wang, Qing; Hu, Rong

doi:10.18632/oncotarget.24166

Cited by 3 publications

(4 citation statements)

References 37 publications

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“…Another study showed that daidzein inhibited the proliferation of GBM cells via CD44/moesin signaling [ 73 ]. Similarly, Pueraria tuberosa has demonstrated a marked anti-osteoporotic effect in ovariectomy-induced osteoporosis because of the antioxidant potential of its components, daidzein, and genistein [ 28 , 74 ].…”

Section: Resultsmentioning

confidence: 99%

Antioxidant and Cytotoxic Activities of Kudzu Roots and Soy Molasses against Pediatric Tumors and Phytochemical Analysis of Isoflavones Using HPLC-DAD-ESI-HRMS

Aboushanab

Шевырин

Slesarev

et al. 2022

Plants

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Pediatric solid tumors (PSTs) are life-threatening and can lead to high morbidity and mortality rates in children. Developing novel remedies to treat these tumors, such as glioblastoma multiforme and sarcomas, such as osteosarcoma, and rhabdomyosarcoma, is challenging, despite immense attempts with chemotherapeutic or radiotherapeutic interventions. Soy (Glycine max) and kudzu roots (KR) (Pueraria spp.) are well-known phytoestrogenic botanical sources that contain high amounts of naturally occurring isoflavones. In the present study, we investigated the antioxidant and cytotoxic effects of the extracts of KR and soy molasses (SM) against PSTs. The green extraction of isoflavones from KR and SM was performed using natural deep eutectic solvents. The extracts were subsequently analyzed by high-performance liquid chromatography (HPLC)-diode array detector (DAD) coupled with high-resolution (HR) mass spectrometry (MS), which identified 10 isoflavones in KR extracts and 3 isoflavones in the SM extracts. Antioxidant and cytotoxic activities of KR and SM extracts were assessed against glioblastoma multiforme (A-172), osteosarcoma (HOS), and rhabdomyosarcoma (Rd) cancer cell lines. The KR and SM extracts showed satisfactory cytotoxic effects (IC50) against the cancer cell lines tested, particularly against Rd cancer cell lines, in a dose-dependent manner. Antioxidant activity was found to be significantly (p ≤ 0.05) higher in KR than in SM, which was consistent with the results of the cytotoxic activity observed with KR and SM extracts against glioblastoma and osteosarcoma cells. The total flavonoid content and antioxidant activities of the extracts were remarkably attributed to the isoflavone content in the KR and SM extracts. This study provides experimental evidence that HPLC-ESI-HRMS is a suitable analytical approach to identify isoflavones that exhibit potent antioxidant and anticancer potential against tumor cells, and that KR and SM, containing many isoflavones, can be a potential alternative for health care in the food and pharmaceutical industries.

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Section: Resultsmentioning

confidence: 99%

Antioxidant and Cytotoxic Activities of Kudzu Roots and Soy Molasses against Pediatric Tumors and Phytochemical Analysis of Isoflavones Using HPLC-DAD-ESI-HRMS

Aboushanab

Шевырин

Slesarev

et al. 2022

Plants

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“…Chrysin down‐regulates Nrf2/ERK signaling pathway by decreasing migration, invasion, and cell proliferation based on the glioma cell lines T98, U251, and U87 invitro at a periodic dose of 0–120 μM respectively 170 . Daidzein induces the arrest in the cell cycle, while it lowers the cells proliferation in glioma cell U87M, U251, U‐118MG, and A‐172 at a dose of 0–20, 40, and 80 μM, respectively, by downregulating the expression of Bcl‐2 and CD44/moesin /β‐catenin signaling pathway in vitro manner 171 . Formononetin shows little cytotoxicity and reduces the cell proliferation in the glioma cell lines U87MG, U251MG, and T98G by lowering HDAC5 expression in vitro at a dose of 0–200 μM 172 .…”

Section: Possible Therapeutics For Astrocytomamentioning

confidence: 99%

“… 170 Daidzein induces the arrest in the cell cycle, while it lowers the cells proliferation in glioma cell U87M, U251, U‐118MG, and A‐172 at a dose of 0–20, 40, and 80 μM, respectively, by downregulating the expression of Bcl‐2 and CD44/moesin /β‐catenin signaling pathway in vitro manner. 171 Formononetin shows little cytotoxicity and reduces the cell proliferation in the glioma cell lines U87MG, U251MG, and T98G by lowering HDAC5 expression in vitro at a dose of 0–200 μM. 172 Genistein, in the glioma cell line U87MG at a dose of 10 μM, increases the arrest of the G2/M cell cycle and cellular apoptosis by downregulating the protein levels of MT1‐MMP and uPAR, as well as MMP‐2 and MMP‐9.…”

Section: Possible Therapeutics For Astrocytomamentioning

confidence: 99%

“…Daidzein induces the arrest in the cell cycle, while it lowers the cells proliferation in glioma cell U87M, U251, U-118MG, and A-172 at a dose of 0-20, 40, and 80 μM, respectively, by downregulating the expression of Bcl-2 and CD44/moesin /β-catenin signaling pathway in vitro manner 171. Formononetin shows little cytotoxicity and reduces the cell proliferation in the glioma cell lines U87MG, U251MG, and T98G by lowering HDAC5 expression in vitro at a dose of 0-200 μM 172.…”

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confidence: 93%

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Unraveling the signaling mechanism behind astrocytoma and possible therapeutics strategies: A comprehensive review

Nahar Metu,

Sutihar,

Sohel

et al. 2023

Cancer Reports

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BackgroundA form of cancer called astrocytoma can develop in the brain or spinal cord and sometimes causes death. A detailed overview of the precise signaling cascade underlying astrocytoma formation has not yet been revealed, although various factors have been investigated. Therefore, our objective was to unravel and summarize our current understanding of molecular genetics and associated signaling pathways with some possible therapeutic strategies for astrocytoma.Recent FindingsIn general, four different forms of astrocytoma have been identified in individuals, including circumscribed, diffuse, anaplastic, and multiforme glioblastoma, according to a recent literature review. All types of astrocytoma have a direct connection with some oncogenic signaling cascade. Common signaling is MAPK cascade, including Ras‐Raf‐ERK, up‐regulated with activating EGFR/AKT/PTEN/mTOR and PDGFR. Recent breakthrough studies found that BRAF mutations, including KIAA1549: BRAF and BRAF V600E are responsible for astrocytoma progression. Additionally, cancer progression is influenced by mutations in some tumor suppressor genes, such as the Tp53/ATRX and MGMT mutant. As synthetic medications must cross the blood–brain barrier (BBB), modulating signal systems such as miRNA is the primary option for treating patients with astrocytoma. However, available surgery, radiation therapy, and experimental therapies such as adjuvant therapy, anti‐angiogenic therapy, and EGFR‐targeting antibody drug are the usual treatment for most types of astrocytoma. Similar to conventional anticancer medications, some phytochemicals slow tumor growth by simultaneously controlling several cellular proteins, including those involved in cell cycle regulation, apoptosis, metastatic spread, tyrosine kinase, growth factor receptor, and antioxidant‐related proteins.ConclusionIn conclusion, cellular and molecular signaling is directly associated with the development of astrocytoma, and a combination of conventional and alternative therapies can improve the malignancy of cancer patients.

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Confinement of FRP concrete columns: Review of design guidelines and comparison with experimental results

2022

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A regulatory framework is required to ensure the correct design of Fibre-Reinforced Polymers (FRPs) increasingly being used as an externally-bonded strengthening system on concrete columns. Several design guidelines on the confinement of FRP concrete have been developed over the past few years worldwide, each proposing a different approach, resulting in different predictions. This study aims to evaluate and compare nine international design guidelines used to predict the compressive strength of confined concrete in FRP-strengthened concrete columns and weigh them against experimental results. The results of this investigation reveal that the predictions from the guidelines on the compressive strengthening of FRP-confined concrete are generally suitable for circular columns, with the ACI-440 and CNR-DT 200 guideline predictions being two of the most accurate. Nevertheless, the guidelines generally tend to overestimate the load-carrying capacity for the compressive strength of FRP-confined concrete in non-circular columns, for which further experimental work using large-scale specimens is required.

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Daidzein derivative daid002 inhibits glioblastoma growth via disrupting the interaction between moesin and CD44

Cited by 3 publications

References 37 publications

Antioxidant and Cytotoxic Activities of Kudzu Roots and Soy Molasses against Pediatric Tumors and Phytochemical Analysis of Isoflavones Using HPLC-DAD-ESI-HRMS

Antioxidant and Cytotoxic Activities of Kudzu Roots and Soy Molasses against Pediatric Tumors and Phytochemical Analysis of Isoflavones Using HPLC-DAD-ESI-HRMS

Unraveling the signaling mechanism behind astrocytoma and possible therapeutics strategies: A comprehensive review

Confinement of FRP concrete columns: Review of design guidelines and comparison with experimental results

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