Daidzein improves insulin resistance in ovariectomized rats

Abstract

We conclude that daidzein can improve insulin resistance induced by ovariectomy by decreasing weight gain, visceral fat accumulation, blood lipids, TNF-α, leptin and IL-6 levels.

Isoflavone supplementation in postmenopausal women does not affect leukocyte LDL receptor and scavenger receptor CD36 expression: A double‐blind, randomized, placebo‐controlled trial

“…This could alter lipid transport, plasma lipoprotein composition, and concentrations [5] and therefore reduce CVD risk in PMW. In contrast to findings in ovariectomized rats, in which daidzein therapy over 12 weeks decreased weight gain and VAT [3], we did not observe effects of the IF intervention on body weight, body fat, and VAT in PMW, which is in line with the results of an animal study perfomed with an identical IF extract over 12 weeks in ovariectomized rats [33]. We are not aware of other studies in humans that investigated effects of an IF extract intervention on these parameters, except of a study for 3 months in PMW with soy protein and IF, in which also no significant effects on VAT have been shown [4].…”

“…We investigated IF effects on body fat, VAT, and body weight, because soy and IFs are discussed to be antiadipogenic and to impact body composition and body fat depots [3,4,33,52]. This could alter lipid transport, plasma lipoprotein composition, and concentrations [5] and therefore reduce CVD risk in PMW.…”

Daidzein, its effects on impaired glucose and lipid metabolism and vascular inflammation associated with type 2 diabetes

“…In the same study, Cheong et al further showed that treatment with daidzein also caused a reduction in nonfasting blood glucose and urinary glucose excretion in KK‐AY/Ta jcl mice, a potent animal model of T2Ds . In ovariectomized rats, daidzein intake at a dose of 50 mg/kg/day decreased the gain in body weight, visceral fat, and the levels of serum insulin, glucose, lipid, insulin resistance, and the secretion of cytokines, namely TNF‐α, leptin, and adiponectin . Another study with high fat diet fed C57BL/6J mice reported the synergistic effect of daidzein and glycitin (0.06% mixture in diet, in the ratio of 3:1) in controlling diabetes and obesity‐related complications.…”

RNA‐Seq analysis reveals the potential molecular mechanisms of daidzein on adipogenesis in subcutaneous adipose tissue of finishing Xianan beef cattle

“…Some studies showed that daidzein could promote adipogenic differentiation and fat deposition (Cho et al, 2010;Hirota et al, 2010;Li et al, 2011). On the other hand, some researchers reported that daidzein inhibited adipogenic differentiation and fat deposition (Cao, Zhang, Zou, & Xia, 2013;Kim et al, 2010;Rachoń, Vortherms, Seidlová-Wuttke, & Wuttke, 2007). On the other hand, some researchers reported that daidzein inhibited adipogenic differentiation and fat deposition (Cao, Zhang, Zou, & Xia, 2013;Kim et al, 2010;Rachoń, Vortherms, Seidlová-Wuttke, & Wuttke, 2007).…”

“…The underlying molecular mechanism was the activation of peroxisome proliferator-activated receptor (PPARr; Cho, Kim, Burgess, & Kim, 2006;Dang & Löwik, 2010;Sakamoto, Naka, Ohara, Kondo, & Iida, 2014), which modulated the expression of several key molecules involved in insulin signalling, lipid metabolism and endocrine function in adipocytes (Cho et al, 2006;Dang & Löwik, 2010;Sakamoto et al, 2014). On the other hand, some researchers reported that daidzein inhibited adipogenic differentiation and fat deposition (Cao, Zhang, Zou, & Xia, 2013;Kim et al, 2010;Rachoń, Vortherms, Seidlová-Wuttke, & Wuttke, 2007). They illuminated that daidzein had oestrogenic properties and could bind to oestrogen receptor α and β (ERα and ERβ, respectively; Dang, Audinot, Papapoulos, Boutin, & Löwik, 2003;Dang & Löwik, 2010), which were the ligand-activated transcription factors for inhibiting adipogenic differentiation (Cooke, Heine, Taylor, & Lubahn, 2001).…”