Daidzein supplementation improved fecundity in sows via modulation of ovarian oxidative stress and inflammation

Xie, Kunhong; Li, Yan; He, Guoru; Zhao, Xuefeng; Chen, Shuai; Yu, Bing; Luo, Yuheng; Mao, Xiangbing; Huang, Zhiqing; Yu, Jie; Luo, Junqiu; Zheng, Ping; Yan, Hui; Li, Hua; He, Jun

doi:10.1016/j.jnutbio.2022.109145

Cited by 7 publications

(4 citation statements)

References 57 publications

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“…The MYD88 triggers the TLR4/NF-κB signaling pathway, which subsequently regulates the inflammatory response by provoking the secretion of cytokines such as IL-1α, IL-1β, and TNF-α [59,60]. The anti-inflammatory effect of DA was also observed in previous studies on sows and Wistar rats [61][62][63].…”

Section: Discussionmentioning

confidence: 58%

Maternal Daidzein Supplementation during Lactation Promotes Growth Performance, Immunity, and Intestinal Health in Neonatal Rabbits

Xie,

Yu,

Wen

et al. 2023

Agriculture

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The main purpose of the present research was to evaluate the effect of varying levels of DA inclusion in maternal diet, in the form of powder, on the born-weaning growth performance (days 1–30) and intestinal health of neonatal rabbits. A total of 152 delivered maternal does (3.94 ± 0.05 kg) were allocated into four groups, with thirty-eight replicates of one doe each, and fed with a control diet (CON) supplemented with different levels of powdered DA (85 mg/kg (DA85), 170 mg/kg (DA170), and 340 mg/kg (DA340)) during lactation. The results show that dietary DA increased individual body weight at days 21 and 30 (p = 0.03 and p < 0.01) and showed a linear and quadratic effect on individual body weight and average daily gain (ADG) (p < 0.05), although ADG was not affected by DA. The serum progesterone (P) (p = 0.05) and glutathione peroxidase (GSH-Px) (p = 0.01) concentrations of maternal rabbits were increased in all maternal DA-supplemented groups and showed a linear and quadratic effect (p < 0.05), while a linear effect was observed in estrogen (E-2) (p < 0.05). Interestingly, the concentrations of the serum insulin-like growth factor-1 (IGF-I) (p < 0.01) and immunoglobulin (IgA and IgG) (p < 0.01 and p = 0.01) in neonatal rabbits were increased in all dietary DA groups, and both showed a linear and quadratic effect (p < 0.05). In addition, the serum interleukin (IL-1β) (p = 0.03) and catalase (CAT) (p = 0.04) concentrations were affected by DA supplements, but linear and quadratic effects were only observed in the catalase (CAT) of neonatal rabbits (p < 0.05). Importantly, the duodenal and jejunal villus heights (p < 0.04 and p = 0.01) and the ratio of villus height to crypt depth (p = 0.02 and p = 0.01) in neonatal rabbits were elevated in all DA-supplemented treatments, while a linear and quadratic effect was observed in jejunum, but a quadratic effect was observed in duodenum (p < 0.05). The ileal villus height (p < 0.01) was also elevated in all DA-supplemented treatments exhibiting both linear and quadratic effects (p < 0.05). Moreover, the expression levels of occludin (p = 0.04), zonula occludens-1 (ZO-1) (p < 0.01), IGF-1 (p = 0.03), and solute carrier family 5 member 9 (SCL5A9) (p < 0.01) in jejunum were markedly elevated in the DA175 and 340 mg/kg DA-supplemented groups and were showing linear and quadratic effects (p < 0.05). Finally, inflammation-related gene expression levels such as NF-κB, TLR4, and MYD88 in jejunal (p = 0.01, p = 0.04, and p < 0.01) and ileal (p = 0.04, p = 0.04, and p = 0.03) epithelium were decreased in the DA170 and DA340 groups (p < 0.05), while linear and quadratic effects were observed for TLR4 in jejunum and for NF-κB and TLR4 MYD88 in ileum (p < 0.05). In summary, as a functional additive, maternal DA supplementation with 170 and 340 mg/kg DA during lactation can promote the growth of neonatal rabbits, which is related to improved antioxidative capacity and immunity, as well as improved intestinal health in neonatal rabbits.

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Section: Discussionmentioning

confidence: 58%

Maternal Daidzein Supplementation during Lactation Promotes Growth Performance, Immunity, and Intestinal Health in Neonatal Rabbits

Xie,

Yu,

Wen

et al. 2023

Agriculture

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“…In a different experimental study, it has also been suggested that daidzein may improve ovarian oxidative stress and inflammation in pigs. This process was thought to be achieved by suppressing the TLR4/NF-κB signaling pathway and activating the Nrf2/HO-1 signaling pathway 29 . Daidzein has been used in experimental studies in recent years as a classical isoflavonic phytoestrogen with specific estrogenic activity.…”

Section: Discussionmentioning

confidence: 99%

Effects of daidzein on rat ovary against ischemia-reperfusion

Toprak,

Akalın,

Öcal

et al. 2023

Acta Cir. Bras.

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Purpose: Our aim was to investigate protective effects of daidzein treatment on ischemia-reperfusion (I/R) injury-induced ovarian tissue by immunohistochemical techniques. Methods: Thirty Sprague Dawley female rats were categorized into three groups as sham, I/R group, and I/R+daidzein groups. Bloods were analyzed for malondialdehyde (MDA), glutathione peroxidase (GSH), and myeloperoxidase (MPO), and ovaries were processed for histological tissue protocol. Results: Both MDA and MPO values were increased in I/R group compared to sham and I/R+daidzein groups. GSH content was increased in I/R+daidzein group compared to I/R groups. In I/R group, theca and follicular cells were degenerated with apoptosis and dilatation and congestion, edema. In I/R+daidzein group, daidzein improved pathologies. In the I/R group, Bax expression was positive with follicular cells, granulosa cells and inflammatory cells. In the I/R+daidzein group, positive Bax reaction was observed in the epithelial, antral, and inflammatory cells. In I/R group, Bcl-2 reaction was in germinative epithelial cells, cells of antral follicle. In the I/R+daidzein group, Bcl-2 expression level was reduced after daidzein treatment. Conclusions: After the I/R procedure, ovarian cells and follicles were degenerated with apoptosis and inflammation. After daidzein treatment, Bax and Bcl-2 signal were decreased. It was observed that daidzein stopped the apoptotic process.

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“…In mice, administration of melatonin improves the fertility and protects against OS and ageing of the ovaries (Zhang et al, 2019). Supplementation of daidzein, which has estrogenic activity, protects sows against ovarian OS and inflammation, which increased the number of embryos in the study by Xie et al (2022).…”

Section: Oxidative S Tre Ssmentioning

confidence: 99%

Pathogenesis of the crosstalk between reproductive function and stress in animals – part 2: Prolactin, thyroid, inflammation and oxidative stress

Jaillardon,

Kaiser

2023

Reprod Domestic Animals

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Stress has a significant impact on reproductive health and fertility in both humans as well as various animal species. In particular, chronic stress can disrupt the delicate balance of the hormonal system that regulates reproductive function, leading to a variety of reproductive disorders and fertility issues. Beside the action of the hypothalamic‐pituitary‐adrenal (HPA) system and the sympatho‐adrenomedullary system (SAM), other subsequent mechanisms have been incriminated. Thus, stress has also been associated with increased prolactin level, resulting in an inhibition of the hypothalamo‐pituitary‐gonadal (HPG) system leading to several reproductive disorders. Thyroid function is inhibited during chronic stress, and therefore considered an important regulator of reproductive function. Thus, and in particular by interfering with the HPA system, stress‐induced immune dysregulation can have adverse effects on reproduction. In addition, oxidative stress and inflammation have been proposed as potential mechanisms by which chronic stress affects reproductive function. This is caused by an increase in reactive oxygen species (ROS) production that has a harmful effect on cells. Furthermore, inflammation can lead to tissue damage and scarring, which can affect fertility. The present review completes the complex mechanism linking stress and reproduction through the current knowledge in various animal species in a comparative point of view.

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Daidzein supplementation improved fecundity in sows via modulation of ovarian oxidative stress and inflammation

Cited by 7 publications

References 57 publications

Maternal Daidzein Supplementation during Lactation Promotes Growth Performance, Immunity, and Intestinal Health in Neonatal Rabbits

Maternal Daidzein Supplementation during Lactation Promotes Growth Performance, Immunity, and Intestinal Health in Neonatal Rabbits

Effects of daidzein on rat ovary against ischemia-reperfusion

Pathogenesis of the crosstalk between reproductive function and stress in animals – part 2: Prolactin, thyroid, inflammation and oxidative stress

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