Daikenchuto (TU-100) ameliorates colon microvascular dysfunction via endogenous adrenomedullin in Crohn’s disease rat model

Kono, Toru; Omiya, Yuji; Hira, Yoshiki; Kaneko, Atsushi; Chiba, Shinichi; Suzuki, Tatsuya; Noguchi, Masamichi; Watanabe, Tsuyoshi

doi:10.1007/s00535-011-0438-2

Cited by 67 publications

(67 citation statements)

References 41 publications

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“…After therapy with daikenchuto, abdominal gas volume assessed by radiographic examination was significantly reduced. Daikenchuto treats abdominal symptoms by enhancing the secretions of motilin (Nagano et al, 1999), substance P (Kono et al, 2008), calcitonin gene-related peptide, and adrenomedullin (Kono et al, 2010(Kono et al, , 2011, and activating the transient receptor potential vanilloid (Kikuchi et al, 2013). Keishikashakuyakuto is also used to treat functional abdominal pain, and the effects on irritable bowel syndrome have been investigated in a double blind RCT (Sasaki et al, 1998).…”

Section: Functional Abdominal Pain or Constipationmentioning

confidence: 99%

Literature Review: Herbal Medicine Treatment after Large-Scale Disasters

et al. 2017

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Large-scale natural disasters, such as earthquakes, tsunamis, volcanic eruptions, and typhoons, occur worldwide. After the Great East Japan earthquake and tsunami, our medical support operation's experiences suggested that traditional medicine might be useful for treating the various symptoms of the survivors. However, little information is available regarding herbal medicine treatment in such situations. Considering that further disasters will occur, we performed a literature review and summarized the traditional medicine approaches for treatment after large-scale disasters. We searched PubMed and Cochrane Library for articles written in English, and Ichushi for those written in Japanese. Articles published before 31 March 2016 were included. Keywords "disaster" and "herbal medicine" were used in our search. Among studies involving herbal medicine after a disaster, we found two randomized controlled trials investigating post-traumatic stress disorder (PTSD), three retrospective investigations of trauma or common diseases, and seven case series or case reports of dizziness, pain, and psychosomatic symptoms. In conclusion, herbal medicine has been used to treat trauma, PTSD, and other symptoms after disasters. However, few articles have been published, likely due to the difficulty in designing high quality studies in such situations. Further study will be needed to clarify the usefulness of herbal medicine after disasters.

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Section: Functional Abdominal Pain or Constipationmentioning

confidence: 99%

Literature Review: Herbal Medicine Treatment after Large-Scale Disasters

et al. 2017

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“…Jejunal blood flow was measured by a laser-Doppler flowmeter (ALF21N, Advance, Tokyo) as previously described (30). Briefly, rats were anesthetized with urethane (900 mg/kg ip), ␣-chloralose (45 mg/kg ip), and butorphanol (1 mg/kg im).…”

Section: Methodsmentioning

confidence: 99%

“…Past studies have shown that TU-100 increases blood flow in the small intestine of normal rats (38) and potentiates the production of vasoactive ADM by IE cells (27,30). Accordingly, we sought to identify the TRP channel involved in the vasodilatory effect of TU-100.…”

Section: Upregulation Of Ibf By Trpv1 and Trpa1 Stimulationmentioning

confidence: 99%

Epithelial transient receptor potential ankyrin 1 (TRPA1)-dependent adrenomedullin upregulates blood flow in rat small intestine

Kono

Kaneko

Omiya

et al. 2013

American Journal of Physiology-Gastrointestinal and Liver Physi

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. TU-100 contains multiple TRP activators. In the present study, therefore, we examined the involvement of TRP channels in the ADM-mediated vasodilatatory effect of TU-100. Rats were treated intraduodenally with the TRP vanilloid type 1 (TRPV1) agonist capsaicin (CAP), the TRP ankyrin 1 (TRPA1) agonist allyl-isothiocyanate (AITC), or TU-100, and jejunum IBF was evaluated using laser-Doppler blood flowmetry. All three compounds resulted in vasodilatation, and the vasodilatory effect of TU-100 was abolished by a TRPA1 antagonist but not by a TRPV1 antagonist. Vasodilatation induced by AITC and TU-100 was abrogated by anti-ADM antibody treatment. RT-PCR and flow cytometry revealed that an IEC-6 cell line originated from the small intestine and purified IE cells expressed ADM and TRPA1 but not TRPV1. AITC increased ADM release in IEC cells remarkably, while CAP had no effect. TU-100 and its ingredient 6-shogaol (6SG) increased ADM release dose-dependently, and the effects were abrogated by a TRPA1 antagonist. 6SG showed similar TRPA1-dependent vasodilatation in vivo. These results indicate that TRPA1 in IE cells may play an important role in controlling bowel microcirculation via ADM release. Epithelial TRPA1 appears to be a promising target for the development of novel strategies for the treatment of various gastrointestinal disorders.daikenchuto; TU-100; vasodilatation; 6-shogaol; inflammatory bowel diseases TRANSIENT RECEPTOR POTENTIAL (TRP) channels are nonselective calcium ion channels ubiquitously expressed in many tissues and are known to participate in a broad range of physical, chemical, and environmental stimuli such as taste, temperature, changes in osmolarity, pressure, stretch, and light.

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“…Further, recent studies have addressed the possibility that DKT increases intestinal blood flow and ameliorates colitis via calcitonin gene-related peptide or adrenomedullin (Murata et al, 2002;Kono et al, 2008Kono et al, , 2010Kono et al, , 2011. The wide range of medicinal actions of DKT has been attributed to its multiple active constituents such as sanshools, shogaols, and ginsenosides.…”

Section: Introductionmentioning

confidence: 99%