Daily Blueberry Consumption Improves Blood Pressure and Arterial Stiffness in Postmenopausal Women with Pre- and Stage 1-Hypertension: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Johnson, Sarah A.; Figueroa, Arturo; Navaei, Negin; Wong, Alexei; Kalfon, Roy; Ormsbee, Lauren; Feresin, Rafaela; Elam, Marcus L.; Hooshmand, Shirin; Payton, Mark E.; Arjmandi, Bahram H.

doi:10.1016/j.jand.2014.11.001

Cited by 203 publications

(225 citation statements)

References 51 publications

Supporting

Mentioning

200

Contrasting

Unclassified

Order By: Relevance

“…In recent years, blueberries have received much attention due to their positive role in human health and disease prevention [8]. For example, blueberry consumption has been shown to improve endothelial function in young healthy men and in people with metabolic syndrome [9,10], and decrease blood pressure and arterial stiffness in pre-and hypertensive postmenopausal women and people with the metabolic syndrome [11,12]. Increasing evidence also suggests that the high polyphenol content of berries may be responsible for their beneficial effects [8,9,[13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Bioavailability of wild blueberry (poly)phenols at different levels of intake

Rodriguez-Mateos

Feliciano

Cifuentes-Gomez

et al. 2016

JBR

View full text Add to dashboard Cite

Abstract. BACKGROUND:Data from human intervention studies have highlighted potential cardiovascular benefits of blueberry (poly)phenols. However, such biological effects are dependent on their bioavailability and, as such, information on the absorption, metabolism and excretion of such compounds is necessary. OBJECTIVE: To investigate whether the bioavailability of blueberry (poly)phenols is intake-dependent, a group of nine healthy volunteers consumed three wild blueberry drinks containing 766 mg (lower), 1278 mg (medium) and 1791 mg (higher) total (poly)phenols, corresponding to 34, 56 and 80 g, respectively, freeze-dried blueberry powder. METHODS: Plasma levels of (poly)phenol metabolites were assessed at baseline and at 1, 2, 4 and 6 hours post-consumption, using UPLC-Q-TOF mass spectrometry. RESULTS: Twenty-three phenolic acid metabolites were quantified in plasma after blueberry consumption. Increases in plasma (poly)phenol metabolites were observed in all the interventions tested. The area under the curve of the concentration over time (AUC) significantly increased when comparing the lower and higher (poly)phenol interventions. Linear doseresponse regressions were obtained for 11 metabolites, while the plasma concentration of the remaining 12 metabolites was not affected by increasing amounts of (poly)phenols in the blueberry interventions. CONCLUSION: Absorption and metabolism of blueberry (poly)phenols are not exclusively intake-dependent at the amounts tested, evidencing a complex metabolic fate of these compounds.

show abstract

Section: Introductionmentioning

confidence: 99%

Bioavailability of wild blueberry (poly)phenols at different levels of intake

Rodriguez-Mateos

Feliciano

Cifuentes-Gomez

et al. 2016

JBR

View full text Add to dashboard Cite

show abstract

“…They are particularly abundant in berries, red grapes, purple sweet potato, red cabbages, and red wine (Mazza & Miniati, 1993). Epidemiological studies indicate that the consumption of products rich in anthocyanins (such as red wine and several species of berries) is associated with a lower risk of cardiovascular diseases (Jennings et al, 2012;Johnson et al, 2015;Wallace, 2011). In addition, anthocyanins display strong free radical scavenging and antioxidant activities, and inhibitory effects on the growth of some cancer cells (Kang, Seeram, Nair, & Bourquin, 2003;Liu et al, 2002).…”

Section: Resultsmentioning

confidence: 99%

Cocomerina pear: an old and rare fruit with red pulp. Analysis of phenolic content and antioxidant/anti-inflammatory capacity

Bucchini

Scoccianti

Ricci

et al. 2016

CyTA - Journal of Food

View full text Add to dashboard Cite

The study evaluated the phenolic content, antioxidant and anti-inflammatory activity (1,1-diphenyl-2-picrylhydrazyl, DPPH, and 5ʹ-lipoxygenase assay, respectively), and oxygen radical absorbance capacity (ORAC), in Cocomerina pear, an old and rare variety of Pyrus communis. There are two cultivars of this pear that ripen in August and October, both of which are nowadays cultivated only in a small area of central Italy. Significant differences in polyphenolic content were observed between these cultivars, with a 30-40% increase in the late ripening cultivar relative to the early ripening one. Anthocyanin concentration was also strongly affected by the period and stage of maturation. In particular, it was 126-fold higher in fruits that ripen in October as compared to those that ripen in August. Ripe fruits of the late cultivar also exhibited higher antioxidant and antiinflammatory activities. These findings suggest that this ancient pear variety should be recovered and considered in the framework of biodiversity conservation.Pera 'Cocomerina': un fruto antiguo y raro de pulpa roja. Análisis del contenido de compuestos fenólicos y capacidad antioxidante/anti-inflamatoria. RESUMENEl estudio evalúa el contenido de compuestos fenólicos, antioxidantes (1,1-diphenyl-2-picrylhydrazyl, DPPH), la actividad anti-inflamatoria (ensayo de la 5ʹ-lipoxigenasa) y la capacidad de absorción del radical oxígeno (ORAC) en la pera Cocomerina, una variedad antigua y rara de Pyrus communis. Existen dos cultivares de esta pera, de maduración en Agosto (cultivar precoz) y de maduración en Octubre (cultivar tardía) y actualmente son cultivadas sólo en una pequeña zona de Italia central. Se detectaron diferencias significativas en contenido de polifenoles entre los cultivares, con un 30 a 40 % de aumento en la cultivar tardía respecto a la cultivar precoz. La concentración de antocianinas también resultó fuertemente afectada por el período y por el estado de maduración. En particular, fue 126 veces más alto en frutos que maduran en Octubre que en aquellos que maduran en Agosto. La fruta madura del cultivar tardío en general mostró mayor actividad antioxidante y de la actividad anti-inflamatoria. Nuestros resultados sugieren que esta variedad antigua de pera debe ser recuperada y además ser considerada en el marco de la conservación de la biodiversidad. ARTICLE HISTORY

show abstract

“…In several short term interventions (< 2mth duration), anthocyanin rich food intake (predominantly blueberries) resulted in a 5-6% decrease in both systolic and diastolic BP (Basu et al 2010;Erlund et al 2008;Johnson et al 2015) and favourable changes in arterial stiffness (Dohadwala et al 2011;Johnson et al 2015). A recent 3-month dose-response study (strawberries, 78 and 155 mg/d anthocyanins) demonstrated beneficial effects on total and LDLcholesterol levels following high intake (Basu et al 2010), and the effect was mediated by improvements in cholesterol efflux capacity (Zhu et al 2014).…”

Section: Randomised Controlled Trials (Rcts)mentioning

confidence: 99%

Berry anthocyanin intake and cardiovascular health

Cassidy

2018

Molecular Aspects of Medicine

156

105

View full text Add to dashboard Cite

Over half of all cardiovascular (CV) events could be prevented by improved diet. This is reflected in government targets for fruit/vegetable intake, yet these are variable across the world (UK: 5-a-day; USA: 9-a-day), do not identify specific fruits/vegetables, and prove hard to achieve. Mounting evidence from prospective studies, supported by recent randomised controlled trials suggest that the benefits of fruits/vegetables may be due to bioactive substances called flavonoids. Specifically one sub-class of flavonoids, the anthocyanins, responsible for the red/blue hue, are receiving growing attention. Although promising data is emerging from cohort studies, and cell/animal studies, proof of efficacy from longer-term randomised controlled trials, and an understanding of the importance of differential metabolism in relation to clinical efficacy are distinctly lacking. Diet related ill-health are among the leading priorities of our time and simple dietary change, including incorporating a few portions of anthocyanin-rich fruit into our diet could have a significant impact at a public health level.

show abstract

Daily Blueberry Consumption Improves Blood Pressure and Arterial Stiffness in Postmenopausal Women with Pre- and Stage 1-Hypertension: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Cited by 203 publications

References 51 publications

Bioavailability of wild blueberry (poly)phenols at different levels of intake

Bioavailability of wild blueberry (poly)phenols at different levels of intake

Cocomerina pear: an old and rare fruit with red pulp. Analysis of phenolic content and antioxidant/anti-inflammatory capacity

Berry anthocyanin intake and cardiovascular health

Contact Info

Product

Resources

About