Daily-diary Evaluated Side Effects of Dose-escalation Radiotherapy of Prostate Cancer Using the Stereotactic Beamcath®R; Technique

Fransson, Per-Anders; Bergström, Per; Löfroth, Per‐Olov; Franzén, Lars; Henriksson, Roger; Widmark, Anders

doi:10.1080/02841860310004346

Cited by 7 publications

(3 citation statements)

References 19 publications

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“…However, our results are comparable to other reports of 3DCRT using the BeamCath technique [9,15]. Furthermore, the 2 cm PTV margin used in most fractions in 3DCRT is wider than what is commonly used in studies of 3DCRT without daily image guidance.…”

Section: Discussionsupporting

confidence: 85%

Improvement in toxicity in high risk prostate cancer patients treated with image-guided intensity-modulated radiotherapy compared to 3D conformal radiotherapy without daily image guidance

Sveistrup¹,

Rosenschöld²,

Deasy

et al. 2014

Radiat Oncol

111

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BackgroundImage-guided radiotherapy (IGRT) facilitates the delivery of a very precise radiation dose. In this study we compare the toxicity and biochemical progression-free survival between patients treated with daily image-guided intensity-modulated radiotherapy (IG-IMRT) and 3D conformal radiotherapy (3DCRT) without daily image guidance for high risk prostate cancer (PCa).MethodsA total of 503 high risk PCa patients treated with radiotherapy (RT) and endocrine treatment between 2000 and 2010 were retrospectively reviewed. 115 patients were treated with 3DCRT, and 388 patients were treated with IG-IMRT. 3DCRT patients were treated to 76 Gy and without daily image guidance and with 1–2 cm PTV margins. IG-IMRT patients were treated to 78 Gy based on daily image guidance of fiducial markers, and the PTV margins were 5–7 mm. Furthermore, the dose-volume constraints to both the rectum and bladder were changed with the introduction of IG-IMRT.ResultsThe 2-year actuarial likelihood of developing grade > = 2 GI toxicity following RT was 57.3% in 3DCRT patients and 5.8% in IG-IMRT patients (p < 0.001). For GU toxicity the numbers were 41.8% and 29.7%, respectively (p = 0.011). On multivariate analysis, 3DCRT was associated with a significantly increased risk of developing grade > = 2 GI toxicity compared to IG-IMRT (p < 0.001, HR = 11.59 [CI: 6.67-20.14]). 3DCRT was also associated with an increased risk of developing GU toxicity compared to IG-IMRT.The 3-year actuarial biochemical progression-free survival probability was 86.0% for 3DCRT and 90.3% for IG-IMRT (p = 0.386). On multivariate analysis there was no difference in biochemical progression-free survival between 3DCRT and IG-IMRT.ConclusionThe difference in toxicity can be attributed to the combination of the IMRT technique with reduced dose to organs-at-risk, daily image guidance and margin reduction.

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Section: Discussionsupporting

confidence: 85%

Improvement in toxicity in high risk prostate cancer patients treated with image-guided intensity-modulated radiotherapy compared to 3D conformal radiotherapy without daily image guidance

Sveistrup¹,

Rosenschöld²,

Deasy

et al. 2014

Radiat Oncol

111

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“…The mean knee height for the participants was 49 cm (range 47-56), corresponding to a calculated mean stature of 156 cm (range 149-175) and the mean BMI, 26 kg/m 2 , was within the normal range (24)(25)(26)(27)(28)(29) suggested for old people (23). Three people had a BMI < 23 and two >30 kg/m 2 .…”

Section: Study Populationmentioning

confidence: 85%

“…The Journal of Nutrition, Health & Aging© Volume 13, Number 9, 2009 Table 1 Personal characteristics, survival after 3 years, anthropometry and changes in body weight and energy intake (7 days) over 6 months, overnight fast (7 days) and bowel movement (14 days) pre-intervention and at the end of the intervention in mean for each participant was registered as number of stools and the BMC was dichotomized into 4 groups: 1) watery, 2) soft, 3) solid, and 4) hard (25), and registered in a diary during the entire intervention period. BW (kg) was assessed with the participants wearing light indoor clothing, without shoes, and recorded to the nearest 0.5 kg, using a chair scale, calibrated to the nearest 0.1 kg.…”

Section: Treatment With Probioticamentioning

confidence: 99%

The feasibility of serving liquid yoghurt supplemented with probiotic bacteria, Lactobacillus rhamnosus LB 21, and Lactococcus lactis L1A — A pilot study among old people with dementia in a residential care facility

Carlsson

Gustafson

Håglin

et al. 2009

The Journal of nutrition, health and aging

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Five-year prospective patient evaluation of bladder and bowel symptoms after dose-escalated radiotherapy for prostate cancer with the BeamCath® technique

Fransson

Bergström

Löfroth

et al. 2006

International Journal of Radiation Oncology*Biology*Physics

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Daily-diary Evaluated Side Effects of Dose-escalation Radiotherapy of Prostate Cancer Using the Stereotactic Beamcath®R; Technique

Cited by 7 publications

References 19 publications

Improvement in toxicity in high risk prostate cancer patients treated with image-guided intensity-modulated radiotherapy compared to 3D conformal radiotherapy without daily image guidance

Improvement in toxicity in high risk prostate cancer patients treated with image-guided intensity-modulated radiotherapy compared to 3D conformal radiotherapy without daily image guidance

The feasibility of serving liquid yoghurt supplemented with probiotic bacteria, Lactobacillus rhamnosus LB 21, and Lactococcus lactis L1A — A pilot study among old people with dementia in a residential care facility

Five-year prospective patient evaluation of bladder and bowel symptoms after dose-escalated radiotherapy for prostate cancer with the BeamCath® technique

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