Daily iron supplementation for prevention or treatment of iron deficiency anaemia in infants, children, and adolescents

Finkelstein, Julia L.; Herman, Herry; Guetterman, Heather; Peña‐Rosas, Juan Pablo; Mehta, Saurabh

doi:10.1002/14651858.cd013227

Cited by 16 publications

(11 citation statements)

References 58 publications

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“…To our knowledge, this is the first systematic review to look at iron or MMN supplementation in infants under six months of age. A Cochrane protocol is registered to analyse daily iron supplementation for prevention or treatment of IDA in infants, children, and adolescents; however, it does not specify if this will include infants under six months of age 74 . A handful of published systematic reviews, discussed below, of iron and/or MMN supplementation in infants and children have been conducted; however, none focused specifically on infants under six months of age 29 , 30 , 35 , 36 , 75 , 76 .…”

Section: Discussionmentioning

confidence: 99%

Acknowledging the gap: a systematic review of micronutrient supplementation in infants under six months of age

et al. 2020

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Background: Micronutrient deficiencies remain common worldwide, but the consequences to growth and development in early infancy (under six months of age) are not fully understood. We present a systematic review of micronutrient interventions in term infants under six months of age, with a specific focus on iron supplementation. Methods: We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (Ovid) and Embase (Ovid) from January 1980 through December 2019. Interventions included iron or multiple micronutrients (MMNs). Results: Of 11,109 records identified, 32 publications from 23 trials were included (18 iron and five MMN supplementation trials). All 23 trials evaluated the effect of supplementation on biochemical outcomes, ten reported on growth, 14 on morbidity and/or mortality and six on neuro-behavioural development. Low- and middle- income countries made up 88% (21/24) of the total trial locations. Meta-analysis was not possible due to extensive heterogeneity in both exposure and outcome measures. However, these trials indicated that infants less than six months of age benefit biochemically from early supplementation with iron, but the effect of additional nutrients or MMNs, along with the impacts on growth, morbidity and/or mortality, and neuro-behavioural outcomes remain unclear. Conclusions: Infants less than six months of age appear to benefit biochemically from micronutrient supplementation. However, well-powered randomised controlled trials are required to determine whether routine supplementation with iron or MMNs containing iron should commence before six months of life in exclusively breast-fed infants in low-resource settings.

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Section: Discussionmentioning

confidence: 99%

Acknowledging the gap: a systematic review of micronutrient supplementation in infants under six months of age

et al. 2020

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“…The lack of a consistent relationship between iron status and outcome from the observational studies reviewed here is possibly a consequence of confounding by other micro-or macronutrient deficiencies. Similarly, micronutrient status was rarely measured within the intervention studies; it is possible that the impact of iron supplementation on development was dependent on the availability of other nutrients [110]. For example, although Black et al reported no improvement in motor skills as a result of iron supplementation alone, infants in the same trial who received combined iron and zinc supplementation did show improvement [68].…”

Section: Strengths and Limitationsmentioning

confidence: 99%

The Role of Iron in Brain Development: A Systematic Review

2020

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One-third of children falter in cognitive development by pre-school age. Iron plays an important role in many neurodevelopmental processes, and animal studies suggest that iron sufficiency in pregnancy and infancy is particularly important for neurodevelopment. However, it is not clear whether iron deficiency directly impacts developmental outcomes, and, if so, whether impact differs by timing of exposure or developmental domain. We searched four databases for studies on iron deficiency or iron supplementation in pregnancy, or at 0–6 months, 6–24 months, or 2–4 years of age. All studies included neurodevelopmental assessments in infants or children up to 4 years old. We then qualitatively synthesized the literature. There was no clear relationship between iron status and developmental outcomes across any of the time windows or domains included. We identified a large quantity of low-quality studies, significant heterogeneity in study design and a lack of research focused on pregnancy and early infancy. In summary, despite good mechanistic evidence for the role of iron in brain development, evidence for the impact of iron deficiency or iron supplementation on early development is inconsistent. Further high-quality research is needed, particularly within pregnancy and early infancy, which has previously been neglected.

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“…Supplementation of Blood Booster Tablets (TTD) for young and eligible women is one of the efforts of the Indonesian government to meet iron intake. Giving iron tablet in the right dose can prevent anemia and increase iron reserves in the body (Fishman et al, 2000;Ministry of Health of Indonesia, 2016;Finkelstein et al, 2018;Stoffel et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Protein and Iron Bioavailability, Perception, Menstrual Cycle as Adolescent Girls’ Anemia Factors

Suarjana¹,

Nursanyoto²,

Dewi³

2021

jhms

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Adolescent girls are one of the groups of people who is prone to iron nutrient deficiency. Iron is required as a substitute for iron lost due to the menstrual cycle. This research aims to determine the trigger factors of anemia in adolescent girls who become participants of the prevention and control program of anemia. This type of research is an observational research with cross sectional design and using statistical test of chelstle method of Mantel Haentzel and OR value for its meaning. The results shows there are four significant triggers of anemia that is perception of adolescent about nutrition (OR = 2,24; 95% CI = 1,05 - 4,76), adherence to TTD (OR = 2,49; 95% CI = 1.11 - 5.58), protein consumption levels (OR = 3.27, 95% CI = 1.57 - 6.84), iron intake (OR = 2.81; 95% CI = 1.30 - 6.05), and duration of menstrual bleeding (OR = 8.08; 95% CI = 1.05 - 61.89). The distribution of blood booster tablets or tablet tambah darah (TTD) needs to be intensified again, accompanied by an emphasis on the benefits of TTD tablets for young women, and to continue to consume independently when the distribution of TTD is terminated. In conclusion, adolescent girls are prevalent to iron nutrient due to menstrual cycle. Therefore, nutrition counseling should also be given besides consuming fresh foods rich in protein and iron as well as vegetables and fruits, because both foods contain vitamin C which greatly helps the absorption of iron in the body.

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Daily iron supplementation for prevention or treatment of iron deficiency anaemia in infants, children, and adolescents

Cited by 16 publications

References 58 publications

Acknowledging the gap: a systematic review of micronutrient supplementation in infants under six months of age

Acknowledging the gap: a systematic review of micronutrient supplementation in infants under six months of age

The Role of Iron in Brain Development: A Systematic Review

Protein and Iron Bioavailability, Perception, Menstrual Cycle as Adolescent Girls’ Anemia Factors

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