Daily moderate alcohol consumption increases serum paraoxonase activity; a diet-controlled, randomised intervention study in middle-aged men

Gaag, M.S. van der; Tol, Arie van; Scheek, L.M.; James, Richard; Urgert, R.; Schaafsma, G.; Hendriks, H.

doi:10.1016/s0021-9150(99)00243-9

Cited by 173 publications

(90 citation statements)

References 28 publications

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“…Alcohol consumption increases HDL-cholesterol [2], with associated increases in paraoxonase activity [2] and cholesterol efflux [29]. This may decrease the amount of cholesterol within peripheral cells, and thus increase the flexibility of the vascular wall.…”

Section: Discussionmentioning

confidence: 99%

“…Mechanisms proposed to explain a positive health effect of moderate alcohol consumption involve prevention of atherogenesis through beneficial effects on lipoprotein metabolism [2], hemostasis [3] and inflammatory processes [4]. In addition, epidemiological studies have shown that moderate alcohol consumption reduces the risk of diabetes mellitus type 2 [5] and increases insulin sensitivity [6].…”

Section: Introductionmentioning

confidence: 99%

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Alcohol consumption and arterial stiffness in men

Sierksma

Muller

Schouw

et al. 2004

Journal of Hypertension

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Objective Moderate alcohol consumption has been proposed to be anti-atherogenic and protect against coronary heart disease. Arterial stiffness provides a summary measure of atherosclerotic arterial damage and cardiovascular risk. A vascular protective effect of moderate alcohol consumption would be reflected in an inverse association between alcohol intake and aortic stiffness.Design A cross-sectional study.Setting The male population of Utrecht.Participants Of 370 men, aged 40-80 years, alcohol intake was calculated from a standardized questionnaire and aortic stiffness was non-invasively assessed by pulsewave velocity (PWV) measurement of the aorta.Results There were no non-drinkers; therefore the group consuming 0-3 glasses of alcoholic beverage per week was chosen as the reference group in the analyses. Those drinking 4-10, 11-21 and 22-58 glasses of alcoholic beverage per week had a 20.77 m/s (95% confidence interval, 21.26 to 20.28), 20.57 m/s (95% confidence interval, 21.07 to 20.08) and 20.14 m/s (95% confidence interval, 20.65 to 0.36) difference in mean PWV compared with those drinking 0-3 glasses per week. Adjustment for factors that correlated with PWV or alcohol consumption did not change the strength of the association.Conclusion Among men aged 40-80 years there is a J-shaped association between alcohol consumption and PWV. This further supports a decreased risk of cardiovascular disease with moderate alcohol consumption.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Alcohol consumption and arterial stiffness in men

Sierksma

Muller

Schouw

et al. 2004

Journal of Hypertension

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“…The benefits of alcohol appear to focus on three major physiological systems. First, increases in HDL-cholesterol levels Van der Gaag et al, 1999), with associated increases in paraoxonase activity (Van der Gaag et al, 1999) and cholesterol efflux (Van der Gaag MS et al, 2001). Second, alcohol may stimulate fibrinolysis (Hendriks et al, 1994) and decrease coagulation (Dimmitt et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Moderate alcohol consumption reduces plasma C-reactive protein and fibrinogen levels; a randomized, diet-controlled intervention study

Sierksma

Gaag

Kluft³

et al. 2002

Eur J Clin Nutr

207

123

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Objective: To evaluate the effect of moderate alcohol consumption on the acute phase proteins C-reactive protein and fibrinogen. Design: Randomized, diet-controlled, cross-over study. Setting: The study was performed at TNO Nutrition and Food Research, Zeist, The Netherlands. Subjects: Ten middle-aged men and 10 postmenopausal women, all apparently healthy, non-smoking and moderate alcohol drinkers, were included. One women dropped out because of a treatment-unrelated cause. The remaining 19 subjects finished the experiment successfully. Interventions: Men consumed four glasses and women consumed three glasses of beer or no-alcohol beer (control) with evening dinner during two successive periods of 3 weeks. The total diet was supplied to the subjects and had essentially the same composition during these 6 weeks. Before each treatment there was a 1 week washout period to compensate for possible carry-over effects. Results: Plasma C-reactive protein and fibrinogen levels were decreased by 35% (P ¼ 0.02) and 12.4% (P 0.001), respectively, after 3 weeks' consumption of beer, as compared to no-alcohol beer consumption. Conclusions: Moderate alcohol consumption significantly decreased plasma C-reactive protein and fibrinogen levels. An antiinflammatory action of alcohol may help explain the link between moderate alcohol consumption and lower cardiovascular disease risk.

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“…Wine consumption increases serum PON1 activity 124,125 . Ethanol and other aliphatic alcohols have been shown to inhibit serum PON1 activity 126 ; however, in middle aged men daily moderate alcohol consumption increased serum PON1 activity, with no differences between wine, beer, and spirits 127 . This increase may be due to the consumption of alcohol itself or to that of antioxidants, as similar results were obtained after consumption of red wine 128 or pomegranate juice 129,130 .…”

Section: Alcoholmentioning

confidence: 99%