Daily variation of brain-derived neurotrophic factor and cortisol in women with normal menstrual cycles, undergoing oral contraception and in postmenopause

Pluchino, Nicola; Cubeddu, Alessandra; Begliuomini, Silvia; Merlini, Sara; Giannini, Andrea; Bucci, Fiorella; Casarosa, Elena; Luisi, M; Cela, Vito; Genazzani, Ar

doi:10.1093/humrep/dep119

Cited by 103 publications

(77 citation statements)

References 41 publications

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“…In particular, during the follicular phase of the menstrual cycle and after menopause, plasma BDNF values were reported to be higher in the morning (8:00 h), followed by a substantial decrease throughout the day, with the lowest values observed at midnight [17]. According to our findings, the diurnal variation of plasma BDNF in FHA showed lower levels than in eumenorrheic women at any sampling time, and interestingly, normal daily variations of BDNF disappeared in FHA patients.…”

Section: Discussionmentioning

confidence: 99%

“…This method has a detection limit of 15.6 pg/ml and intra- and interassay variation coefficients of 6.0 and 8.5%, respectively. We used a highly specific antiserum, which indicates <3.0% cross-reactivity with other related neurotrophic factors (NGF, NT-3, NT-4) at a concentration of 100 ng/ml, as specified in the manufacturer's notes [17]. …”

Section: Methodsmentioning

confidence: 99%

“…BDNF plasma levels are related to sex hormones, showing variations during the menstrual cycle and during hormonal treatments [16]. In addition, BDNF diurnal variation in eumenorrheic women seems to be influenced by the ovarian and adrenal function, and BDNF values are correlated with the cortisol (F) circadian rhythm [17]. …”

Section: Introductionmentioning

confidence: 99%

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Diurnal Variation of Plasma Brain-Derived Neurotrophic Factor Levels in Women with Functional Hypothalamic Amenorrhea

et al. 2015

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Background: Brain-derived neurotrophic factor (BDNF) is strongly related to hormonal networks and is modulated by hypothalamic activity. Objective: To evaluate plasma BDNF concentration in patients with functional hypothalamic amenorrhea (FHA), with reference to the BDNF circadian rhythm and its relation with the cortisol (F) rhythm, and to assess whether the duration of amenorrhea might influence the BDNF:F ratio in FHA. Design: This was an observational study evaluating 36 amenorrheic and 30 eumenorrheic women. Setting: Basal values of BDNF and hormones were examined in blood samples collected from 7:00 to 9:00 h in all the women. Basal BDNF and F levels were determined in blood samples collected in 12 subjects from each group at 8:00, 12:00, 16:00, 20:00, and 24:00 h. Results: BDNF plasma levels are significantly lower in amenorrheic women (p < 0.001) than in the follicular phase of eumenorrheic women. There are no correlations between BDNF values (p > 0.05), sex steroids, and F in FHA. Low plasma BDNF levels in FHA are not significantly correlated with duration of amenorrhea. The 24-hour variation of BDNF in amenorrheic women is significantly lower when compared to the control group, andnormal daily variations of BDNF disappeared in FHA patients. F preserved its circadian rhythm in both groups. Conclusions: Interactions between BDNF, the hypothalamus-pituitary-adrenal axis, and sex steroids might be critical in clinical conditions of modified homeostasis/adaptation, such as FHA.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Diurnal Variation of Plasma Brain-Derived Neurotrophic Factor Levels in Women with Functional Hypothalamic Amenorrhea

et al. 2015

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“…Whether local oestradiol produced by granulosa cells within the ovary also alters extraneuronal neurotrophin expression remains to be determined. However, it has been shown that circulating levels of oestradiol are positively associated with BDNF concentrations in women undergoing fertility treatment (Monteleone et al 2007), and plasma BDNF levels fluctuate during a menstrual cycle (Cubeddu et al 2011), declining in post-menopausal women (Lommatzsch et al 2005, Pluchino et al 2009), but can be increased through hormone replacement . Steroid hormones also influence NGF.…”

Section: R49mentioning

confidence: 99%

The roles of glial cell line-derived neurotrophic factor, brain-derived neurotrophic factor and nerve growth factor during the final stage of folliculogenesis: a focus on oocyte maturation

Linher‐Melville¹,

Li²

2013

Reproduction

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Neurotrophic factors were first identified to promote the growth, survival or differentiation of neurons and have also been associated with the early stages of ovarian folliculogenesis. More recently, their effects on the final stage of follicular development, including oocyte maturation and early embryonic development, have been reported. Glial cell line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), which are expressed in numerous peripheral tissues outside of the CNS, most notably the ovary, are now known to stimulate oocyte maturation in various species, also enhancing developmental competence. The mechanisms that underlie their actions in antral follicles, as well as the targets ultimately controlled by these factors, are beginning to emerge. GDNF, BDNF and NGF, alone or in combination, could be added to the media currently utilized for in vitro oocyte maturation, thereby potentially increasing the production and/or quality of early embryos.Reproduction (2013) 145 R43-R54

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“…BDNF, E 2 and P measurements in FF FF BDNF level was determined by enzyme-linked immunosorbent assay (ELISA) method (BDNF Emax Immunoassay System, Promega, USA) as previous described [11,12]. Briefly, the samples were diluted with Block & Sample Buffer.…”

Section: Ff Collectionmentioning

confidence: 99%

Brain-derived neurotrophic factor from follicular fluid is positively associated with rate of mature ooocytes collected and cleavage rate in intracytoplasmic sperm injection patients

Wang¹,

Sun²,

Zhen³

et al. 2011

J Assist Reprod Genet

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Purpose The aim of the study was to evaluate the correlation between BDNF and oocyte maturation and to verify whether BDNF could predict in vitro fertilization (IVF) outcome. Methods The follicle fluid (FF) for BDNF, E 2 and P assay were obtained from 59 patients undergoing intracytoplasmic sperm injection (ICSI). The women were divided into two groups by pregnancy outcome and their clinical and lab data were compared. And the correlation of BDNF with E 2 , P, age, and IVF data were analyzed. Results Positive correlation was observed between BDNF and E 2 concentration in FF. BDNF was positively correlated with the rate of mature oocytes collected and cleavage rate. Conclusions The BDNF in FF could not predict IVF outcome, but BDNF in FF might play an important role in the maturation of oocyte and development of oocyte into preimplantation embryo.

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Daily variation of brain-derived neurotrophic factor and cortisol in women with normal menstrual cycles, undergoing oral contraception and in postmenopause

Cited by 103 publications

References 41 publications

Diurnal Variation of Plasma Brain-Derived Neurotrophic Factor Levels in Women with Functional Hypothalamic Amenorrhea

Diurnal Variation of Plasma Brain-Derived Neurotrophic Factor Levels in Women with Functional Hypothalamic Amenorrhea

The roles of glial cell line-derived neurotrophic factor, brain-derived neurotrophic factor and nerve growth factor during the final stage of folliculogenesis: a focus on oocyte maturation

Brain-derived neurotrophic factor from follicular fluid is positively associated with rate of mature ooocytes collected and cleavage rate in intracytoplasmic sperm injection patients

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