In order to study the influence of freeze-thaw cycle on the flexural performance of asphalt pavement, semi-circular flexural test (SCB) is carried out. Coal gangue powder (accounting for 0%, 25%, 50%, 75% and 100% by weight of ore powder) is used to replace ore powder to improve the freeze-thaw resistance of asphalt.According to the test data, the load-displacement curve is drawn, the ultimate tensile stress(σt) is studied, and the variation law of different coal gangue powder replacement rates under different freeze-thaw cycles (0, 2, 4, and 6 times) is analyzed by ultimate tensile stress. The test results show that the best replacement rate of coal gangue powder is 50%, and σt decreases with the increase of freeze-thaw cycles, so adding coal gangue powder can reduce the influence of freeze-thaw cycles on the bending performance of asphalt pavement. By analyzing the load-displacement curve, energy indexes such as WD(total work from initial failure to complete failure), WU(energy dissipation from initial failure to complete failure), WS(work from initial failure to specimen failure) and η are obtained. In the freeze-thaw cycle, with the increase of cycle times, the energy consumption of WD, WU and WS decreases, which aggravates the damage of asphalt mixture and reduces the flexural capacity of specimens. Among them, six freeze-thaw cycles have the lowest flexural capacity of specimens, indicating that freeze-thaw damage directly affects the flexural performance of asphalt mixture.