Dangerous dietary supplements:<i>Garcinia cambogia</i>-associated hepatic failure requiring transplantation

Lunsford, Keri E.; Bodzin, Adam S.; Reino, Diego; Wang, Hanlin L.; Busuttil, Ronald W.

doi:10.3748/wjg.v22.i45.10071

Cited by 65 publications

(52 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…135 A 34-year-old Hispanic male required liver transplantation after the intake of G. cambogia 3 times a day. 136 A review article that was published in the same year listed G. cambogia among a list of dietary supplements that are hepatotoxic. 137 A 51-year-old female with a 12-year history of type 1 bipolar disorder started consuming G. cambogia and was easily irritated and agitated.…”

Section: Resultsmentioning

confidence: 99%

Awareness on the possible adverse effects of Garcinia cambogia: A scientific approach

Zothantluanga

Lalnunpuii

Bhat

et al. 2020

Sci Vis

View full text Add to dashboard Cite

The modern popular ideology is that plant-based products do not have adverse effects. Hence, people are fond of using herbal products of their choice to treat their own ailments or anyone else. As majority of the population are not aware of herbal toxicity concept, the use of formulated single or combined medicinal and/or nutritional plant extracts or isolated compounds to treat chronic diseases are increasingly popular due to the widespread concerns regarding the adverse effects of pharmaceutical drugs. Awareness from the scientific community to bring society to its senses regarding the safety issue of a herbal product is rare. Garcinia gummi-gutta (more popularly known by the synonym Garcinia cambogia in commercial preparations), belonging to the family of Clusiaceae (alt. Guttiferae) is a popularly consumed weight-loss nutraceutical. This review aims to highlight the possible adverse effects of G. cambogia. For the said purpose, 147 articles were collected from PubMed, Web of Science and Google scholar. Literature review revealed a plethora of beneficial actions. Investigational outcomes and clinical evidences hint the possible adverse effects likely to be linked with the use of G. cambogia. However, the use of G. cambogia as an anti-obesity agent is advisable as long as the therapeutic value outweighs the adverse effect.

show abstract

Section: Resultsmentioning

confidence: 99%

Awareness on the possible adverse effects of Garcinia cambogia: A scientific approach

Zothantluanga

Lalnunpuii

Bhat

et al. 2020

Sci Vis

View full text Add to dashboard Cite

show abstract

“…Recent studies have described (hypo)mania and/or psychosis after the consumption of G. cambogia [ 87 , 119 , 120 , 121 ]. Some liver complications have also been reported, such as hepatotoxicity, with acute hepatic lesions, acute hepatitis, and hepatic insufficiency requiring transplant [ 122 , 123 , 124 , 125 ]. The complications from G. cambogia include mania or hypomania, mania with psychosis, and serotonin syndrome [ 10 , 126 ].…”

Section: Garcinia Species and Bioactive Compounmentioning

confidence: 99%

“…Lipidic peroxidation also increases oxidative stresss and can increase the risk of acute pancreatitis in patients using the species [ 131 ]. G. cambogia can cause other severe adverse events, including hepatoxicity and secondary acute hepatic insufficiency [ 124 , 132 ]. Other studies have also shown acute necrotizing eosinophilic myocarditis, rhabdomyolysis, serotonin toxicity, and nephropathy secondary to the use of G. cambogia [ 87 , 121 , 122 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 ].…”

Section: Garcinia Species and Bioactive Compounmentioning

confidence: 99%

Medicinal Potential of Garcinia Species and Their Compounds

et al. 2020

View full text Add to dashboard Cite

Garcinia is a genus of Clusiaceae, distributed throughout tropical Asia, Africa, New Caledonia, Polynesia, and Brazil. Garcinia plants contain a broad range of biologically active metabolites which, in the last few decades, have received considerable attention due to the chemical compositions of their extracts, with compounds which have been shown to have beneficial effects in several diseases. Our work had the objective of reviewing the benefits of five Garcinia species (G. brasiliensis, G. gardneriana, G. pedunculata, G. cambogia, and G. mangstana). These species provide a rich natural source of bioactive compounds with relevant therapeutic properties and anti-inflammatory effects, such as for the treatment of skin disorders, wounds, pain, and infections, having demonstrated antinociceptive, antioxidant, antitumoral, antifungal, anticancer, antihistaminic, antiulcerogenic, antimicrobial, antiviral, vasodilator, hypolipidemic, hepatoprotective, nephroprotective, and cardioprotective properties. This demonstrates the relevance of the genus as a rich source of compounds with valuable therapeutic properties, with potential use in the prevention and treatment of nontransmissible chronic diseases.

show abstract

“…In one human trial, HCA has been supplemented with doses up to 5600 mg/day without adverse effects [168]. However, case reports have described severe hepatotoxicity, including acute liver failure requiring liver transplantation and acute necrotizing eosinophilic myocarditis in subjects using pure Garcinia cambogia supplements [169][170][171][172]. A natural product for weight loss containing Garcinia cambogia and a variety of other ingredients has been associated to fatigue, nausea, vomiting, colic, fever, chills, anorexia, abdominal pain, jaundice, increased levels of liver enzymes and bilirubin in healthy adults [173].…”

Section: Toxicity and Reactivitymentioning

confidence: 99%

A Critical Review on the Role of Food and Nutrition in the Energy Balance

Fadda

Fedele

et al. 2020

Nutrients

View full text Add to dashboard Cite

The mass media has increasingly frequently suggested to the general population that specific foods or nutritional schemes are able to affect both human metabolism and energy expenditure, thus facilitating weight loss. This critical review is aimed at assessing available evidence on the roles of nutrients, food and dietary regimens in energy intake and energy expenditure. We queried the National Library of Medicine, the Cochrane Library, Excerpta Medica dataBASEand the Cumulative Index to Nursing and Allied Health Literature database, and a search strategy was performed by using database-specific subject headings and keywords. We found that available scientific evidence on these topics is scarce, and that the limited number of available studies often have poor methodological quality. Only a few foods show beneficial effects on metabolism and energy expenditure, as the human energy balance is complex and multifactorial. Finally, microbiota may interfere with the intake, use and expenditure of energy in the human body. Conclusive evidence is still lacking, and, at present, it is not possible to identify a food or a diet with a significant impact on human energy expenditure.

show abstract

Dangerous dietary supplements:Garcinia cambogia-associated hepatic failure requiring transplantation

Cited by 65 publications

References 18 publications

Awareness on the possible adverse effects of Garcinia cambogia: A scientific approach

Awareness on the possible adverse effects of Garcinia cambogia: A scientific approach

Medicinal Potential of Garcinia Species and Their Compounds

A Critical Review on the Role of Food and Nutrition in the Energy Balance

Contact Info

Product

Resources

About