Daño renal agudo secundario a nefritis tubulointersticial aguda por uso de medicamentos. Caso clínico

Oikonomopoulou, Niki; López, Ana Belén Martínez; Urbano, Javier; Molina, María del Carmen Molina; Laiseca, Laura Butragueño; Nuñez, Daniel Barraca; Blanco, Olalla Álvarez

doi:10.4067/s0370-41062017000600787

Cited by 3 publications

(1 citation statement)

References 8 publications

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“…We can associate this result with the common use of energy drinks among adolescents. When examined in terms of aTIN causes, first place was medications (56.2%) followed by energy drinks (9%), different to the literature (8,9). None of our patients with aTIN diagnosis linked to energy drinks had additional medication use or other comorbid disease.…”

Section: Discussionmentioning

confidence: 76%

Retrospective Analysis and Literature Review of Acute Tubulointerstitial Nephritis Cases Linked to Energy Drinks

Çelakıl¹,

Taktak²

2021

Mustafa Kemal Üniversitesi Tıp Dergisi

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Objective: Acute tubulointerstitial nephritis (aTIN) is a rare cause of acute renal injury in children. The incidence of cases linked to insensible use of energy drinks has increased in recent years. In thıs study, we aimed to examine patients with aTIN connected to energy drink in detail in our own patients.Methods: In this study, the files of patients with acute tubulointerstitial nephritis (aTIN in the pediatric nephrology clinic were retrospectively screened.Results: 32 patients were included in the study (F/M: 22/10). Mean age was 12±4.3 years (9-17). The most common causes in etiology were drugs (18; 56.2%) and energy drinks (9; 28.1%). The most common attendance symptoms were vomiting (84.3%), fatigue (68.7%), hypertension (56.2%), abdominal pain (40.6%), joint pain (34.3%), fever (31.2%). The mean duration from onset of symptoms to first attendance at hospital was 3.8±2.1 days, with the mean duration between first intake of causative agent to onset of symptoms 9±4.1 days.Conclusion: The inclusion of energy drink use among candidates for causes of aTIN in recent years is an important health problem. Due to serious side effect profile beginning with acute kidney injury and resulting in CKD, it is a cause that should definitely be questioned in the anamnesis of young patients especially.

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Section: Discussionmentioning

confidence: 76%

Retrospective Analysis and Literature Review of Acute Tubulointerstitial Nephritis Cases Linked to Energy Drinks

Çelakıl¹,

Taktak²

2021

Mustafa Kemal Üniversitesi Tıp Dergisi

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Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years

Ziesenitz

Welzel²,

Dyk³

et al. 2022

Pediatr Drugs

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Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in infants, children, and adolescents worldwide; however, despite sufficient evidence of the beneficial effects of NSAIDs in children and adolescents, there is a lack of comprehensive data in infants. The present review summarizes the current knowledge on the safety and efficacy of various NSAIDs used in infants for which data are available, and includes ibuprofen, dexibuprofen, ketoprofen, flurbiprofen, naproxen, diclofenac, ketorolac, indomethacin, niflumic acid, meloxicam, celecoxib, parecoxib, rofecoxib, acetylsalicylic acid, and nimesulide. The efficacy of NSAIDs has been documented for a variety of conditions, such as fever and pain. NSAIDs are also the main pillars of anti-inflammatory treatment, such as in pediatric inflammatory rheumatic diseases. Limited data are available on the safety of most NSAIDs in infants. Adverse drug reactions may be renal, gastrointestinal, hematological, or immunologic. Since NSAIDs are among the most frequently used drugs in the pediatric population, safety and efficacy studies can be performed as part of normal clinical routine, even in young infants. Available data sources, such as (electronic) medical records, should be used for safety and efficacy analyses. On a larger scale, existing data sources, e.g. adverse drug reaction programs/networks, spontaneous national reporting systems, and electronic medical records should be assessed with childspecific methods in order to detect safety signals pertinent to certain pediatric age groups or disease entities. To improve the safety of NSAIDs in infants, treatment needs to be initiated with the lowest age-appropriate or weight-based dose. Duration of treatment and amount of drug used should be regularly evaluated and maximum dose limits and other recommendations by the manufacturer or expert committees should be followed. Treatment for non-chronic conditions such as fever and acute (postoperative) pain should be kept as short as possible. Patients with chronic conditions should be regularly monitored for possible adverse effects of NSAIDs.

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Amoxicillin/ibuprofen

2018

Reactions Weekly

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Daño renal agudo secundario a nefritis tubulointersticial aguda por uso de medicamentos. Caso clínico

Cited by 3 publications

References 8 publications

Retrospective Analysis and Literature Review of Acute Tubulointerstitial Nephritis Cases Linked to Energy Drinks

Retrospective Analysis and Literature Review of Acute Tubulointerstitial Nephritis Cases Linked to Energy Drinks

Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years

Amoxicillin/ibuprofen

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