Dantrolene

Britt, Beverley A.

doi:10.1007/bf03011484

Cited by 92 publications

(20 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It acts peripherally and inhibits the excitation-contraction mechanism by halothane and caffeine in skeletal muscle through Ca 2+ release from the sarcoplasmic reticulum (Ohnishi et al, 1983;Britt, 1984;Ohta et al, 1990). The clinical effects of dantrolene are thought to be consistent with its effectiveness as a blocker of ryanodine receptor-mediated Ca 2+ release from intracellular Ca 2+ stores.…”

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Effect of dantrolene on KCl- or NMDA-induced intracellular Ca2+ changes and spontaneous Ca2+ oscillation in cultured rat frontal cortical neurons

Hayashi

Kagaya

Takebayashi

et al. 1997

J. Neural Transmission

View full text Add to dashboard Cite

Dantrolene has been known to affect intracellular Ca2+ concentration ([Ca2+]i) by inhibiting Ca2+ release from intracellular stores in cultured neurons. We were interested in examining this property of dantrolene in influencing the [Ca2+]i affected by the NMDA receptor ligands, KCl, L-type Ca2+ channel blocker nifedipine, and two other intracellular Ca2(+)-mobilizing agents caffeine and bradykinin. Effect of dantrolene on the spontaneous oscillation of [Ca2+]i was also examined. Dantrolene in microM concentrations dose-dependently inhibited the increase in [Ca2+]i elicited by NMDA and KCl. AP-5, MK-801 (NMDA antagonists), and nifedipine respectively reduced the NMDA and KCl-induced increase in [Ca2+]i. Dantrolene, added to the buffer solution together with the antagonists or nifedipine, caused a further reduction in [Ca2+]i to a degree similar to that seen with dantrolene alone inhibiting the increase in [Ca2+]i caused by NMDA or KCl. At 30 microM, dantrolene partially inhibited caffeine-induced increase in [Ca2+]i whereas it has no effect on the bradykinin-induced change in [Ca2+]i. The spontaneous oscillation of [Ca2+]i in frontal cortical neurons was reduced both in amplitude and in base line concentration in the presence of 10 microM dantrolene. Our results indicate that dantrolene's mobilizing effects on intracellular Ca2+ stores operate independently from the influxed Ca2+ and that a component of the apparent increase in [Ca2+]i elicited by NMDA or KCl represents a dantrolene-sensitive Ca2+ release from intracellular stores. Results also suggest that dantrolene does not affect the IP3-gated release of intracellular Ca2+ and that the spontaneous Ca2+ oscillation is, at least partially, under the control of Ca2+ mobilization from internal stores.

show abstract

Section: Introductionmentioning

confidence: 97%

“…Clinically, dantrolene induces adverse central effects such as somnolence and depression (Britt, 1984). This drug has also been reported to alter levels of monoamine metabolites in human spinal fluid (Nishijima and Ishiguro, 1993).…”

Section: Introductionmentioning

confidence: 99%

Effect of dantrolene on KCl- or NMDA-induced intracellular Ca2+ changes and spontaneous Ca2+ oscillation in cultured rat frontal cortical neurons

Hayashi

Kagaya

Takebayashi

et al. 1997

J. Neural Transmission

View full text Add to dashboard Cite

show abstract

“…Whereas the evolution of the disease can be fatal and occurs quickly, early diagnosis and specific treatment are of great importance, reducing mortality from 80% to less than 10% of the cases [8,9]. Thus, encountering the signs described for the disease associated with the use of volatile anesthetics agents, it must be considered a case of malignant hyperthermia and specific treatment protocol must be initiated [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…Thus, encountering the signs described for the disease associated with the use of volatile anesthetics agents, it must be considered a case of malignant hyperthermia and specific treatment protocol must be initiated [8,9]. There should be immediate cessation of the exposure to possible agents triggering of malignant hyperthermia with replacement by safe anesthetic drugs, followed by administration of dantrolene sodium or sodium azumolene, with the goal of correcting cellular metabolism of calcium, cardiac function, body temperature and respiration rate [7,[10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Physico-Chemical Characterization and Analytical Development for Sodium Azumolene, a Potential Drug Designed to Fight Malignant Hyperthermia

Corrêa¹,

Hiene²,

Salgado³

2014

J Anal Bioanal Tech

View full text Add to dashboard Cite

Sodium azumolene is a drug designed to fight Malignant Hyperthermia (MH), which is characterized by genetic predisposition and triggered by the use of inhalational anesthetics. This drug is shown as a water-soluble analogue of dantrolene sodium, 30-folds more water soluble, which gives advantages for its emergency use. To our knowledge there is no analytical method for sodium zaumolene raw material or dosage form published so far. The objective of the present investigation was to develop and validate analytical methods to achieve sodium azumolene chemical identification and quantification. The sodium azumolene was characterized regarding its thermal behavior, by differential thermal analysis and thermogravimetric analysis; Visible, UV and infrared absorption. To accurately assess the sodium Azumolene content three different analytical methods (visible and UV spectrophotometry and high performance liquid chromatography) were developed and validated. All methods showed to be linear, accurate, precise and reliable. Azumolene has shown to be equipotent to dantrolene in the treatment and prevention of an MH crisis and the great advantage compared to dantrolene is better water solubility. This study has characterized the sodium azumolene and presents new analytical methods which have not been reported so far.

show abstract

“…Tel: 82-62-970-2482, 2483, Fax: 82-62-970-2484 been limited due to its low solubility in water, especially at neutral pH (Britt, 1984). Partial inhibition of halothane-induced Ca 2+ release from MHS SR by dantrolene-Na was reported previously (Ohnishi et al, 1983).…”

mentioning

confidence: 95%

Effects of azumolene on Ryanodine binding to sarcoplasmic reticulum of normal and malignant hyperthermia susceptible swine skeletal muscles

Kim

Lee

1997

Korean Journal of Biological Sciences

View full text Add to dashboard Cite

Dantrolene

Cited by 92 publications

References 92 publications

Effect of dantrolene on KCl- or NMDA-induced intracellular Ca2+ changes and spontaneous Ca2+ oscillation in cultured rat frontal cortical neurons

Effect of dantrolene on KCl- or NMDA-induced intracellular Ca2+ changes and spontaneous Ca2+ oscillation in cultured rat frontal cortical neurons

Physico-Chemical Characterization and Analytical Development for Sodium Azumolene, a Potential Drug Designed to Fight Malignant Hyperthermia

Effects of azumolene on Ryanodine binding to sarcoplasmic reticulum of normal and malignant hyperthermia susceptible swine skeletal muscles

Contact Info

Product

Resources

About