Dapsone‐induced agranulocytosis—possible involvement of low‐activity <i>N</i>‐acetyltransferase 2

Potočnjak, Ines; Likić, Robert; Šimić, Iveta; Nahal, D. Juricic; Cegec, I.; Ganoci, Lana; Božina, Nada

doi:10.1111/fcp.12287

Cited by 7 publications

(2 citation statements)

References 30 publications

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“…Patients on dapsone therapy should have a baseline complete blood count (CBC), liver function tests and a G6PD level. Hypo‐ or agranulocytosis may emerge within the first 3 months of treatment, possibly due to low activity of the N‐acetyltransferase‐2 enzyme 117 . Hence, blood cell count should be checked weekly for the first month, every 2 weeks for the next 2 months, and at least every 3 months thereafter.…”

Section: Treatmentmentioning

confidence: 99%

S2k guidelines on diagnosis and treatment of linear IgA dermatosis initiated by the European Academy of Dermatology and Venereology

Caux,

Patsatsi,

Karakioulaki

et al. 2024

Acad Dermatol Venereol

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IntroductionLinear IgA dermatosis (LAD) is a rare subepidermal autoimmune bullous disease (AIBD) defined by predominant or exclusive immune deposits of immunoglobulin A at the basement membrane zone of skin or mucous membranes. This disorder is a rare, clinically and immunologically heterogeneous disease occurring both in children and in adults. The aim of this project is to present the main clinical features of LAD, to propose a diagnostic algorithm and provide management guidelines based primarily on experts' opinion because of the lack of large methodologically sound clinical studies.MethodsThese guidelines were initiated by the European Academy of Dermatology and Venereology (EADV) Task Force Autoimmune Bullous Diseases (AIBD). To achieve a broad consensus for these S2k consensus‐based guidelines, a total of 29 experts from different countries, both European and non‐European, including dermatologists, paediatric dermatologists and paediatricians were invited. All members of the guidelines committee agreed to develop consensus‐based (S2k) guidelines. Prior to a first virtual consensus meeting, each of the invited authors elaborated a section of the present guidelines focusing on a selected topic, based on the relevant literature. All drafts were circulated among members of the writing group, and recommendations were discussed and voted during two hybrid consensus meetings.ResultsThe guidelines summarizes evidence‐based and expert opinion‐based recommendations (S2 level) on the diagnosis and treatment of LAD.ConclusionThese guidelines will support dermatologists to improve their knowledge on the diagnosis and management of LAD.

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Section: Treatmentmentioning

confidence: 99%

S2k guidelines on diagnosis and treatment of linear IgA dermatosis initiated by the European Academy of Dermatology and Venereology

Caux,

Patsatsi,

Karakioulaki

et al. 2024

Acad Dermatol Venereol

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“…The dosage of dapsone must be lowered in these patients. Agranulocytosis is a rare but serious complication and is almost always seen at the beginning of the therapy [101]. Systemic drug hypersensitivity syndrome is another side effect of dapsone treatment, which must also be kept in mind [102].…”

Section: Treatmentmentioning

confidence: 99%

Dermatitis herpetiformis

Schotte¹

2020

Chin J Dermatol

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Dermatitis herpetiformis is an autoimmune skin disease, which is strongly related to coeliac disease. Moreover, some authors accept it as the skin manifestation of coeliac disease. It is a chronic, recurrent disease with polymorphic skin eruptions and pruritus. Dermatitis herpetiformis is a disease of the young adults mostly, but can be seen at any age. It is characterized by papules, vesicles, excoriations, and urticarial plaques clinically. Histopathological examination reveals subepidermal separation, and with this finding, it needs to be differentiated from linear IgA bullous dermatitis and bullous pemphigoid. In this case, direct immunofluorescence is helpful. Granular deposition of IgA is pathognomonic for dermatitis herpetiformis. Dermatitis herpetiformis can accompany other autoimmune disorders such as type I diabetes mellitus, thyroid diseases, vitiligo, and collagen tissue diseases. Dermatitis herpetiformis is, usually, successfully treated with dapsone and gluten-free diet.

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Drug-Induced Neutropenia During Treatment of Non-Neoplastic Dermatologic Diseases: A Review

Hsieh

Tsai

2020

Clin Drug Investig

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Dapsone‐induced agranulocytosis—possible involvement of low‐activity N‐acetyltransferase 2

Cited by 7 publications

References 30 publications

S2k guidelines on diagnosis and treatment of linear IgA dermatosis initiated by the European Academy of Dermatology and Venereology

S2k guidelines on diagnosis and treatment of linear IgA dermatosis initiated by the European Academy of Dermatology and Venereology

Dermatitis herpetiformis

Drug-Induced Neutropenia During Treatment of Non-Neoplastic Dermatologic Diseases: A Review

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