2023
DOI: 10.21203/rs.3.rs-2854956/v1
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DAPT improves behavioral abnormalities and rescues the hippocampal Oligodendrocyte precursor cell differentiation in cuprizone-induceddemyelination mouse model

Abstract: Introduction: Oligodendrocyte precursor cells (OPCs) differentiation dysfunction is closely related to demyelinating diseases and cognitive dysfunction. P75 neurotrophin receptor (P75NTR) is a prototypical co-receptor that induces Schwann cell death via γ-secretase-dependent regulated intramembrane proteolysis. This study hypothesizes that P75NTR may also assists in inhibiting OPCs differentiation.Methods Male C57BL/6 mice were fed 0.2% cuprizone (CPZ) continuously for 6 weeks to establish the acute demyelinat… Show more

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