Darier and Ferrand's dermatofibrosarcoma: A carcinologic and cosmetologic challenge in a low-income country

Somé, Ollo Roland; Diallo, Malick; Konkobo, Damien; Belemlilga, G. Larba Hermann; Nassirou, Yabré; Konsegré, V.; Zaré, Cryprien

doi:10.1016/j.bulcan.2019.11.018

Cited by 2 publications

(10 citation statements)

References 14 publications

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“…These criteria designate a group of dermatofibrosarcomas at high risk of recurrence. Dermatofibrosarcoma is well recognized for its high propensity to recur 17,26,36 . Our patients had a tumor that had already recurred on admission to our centers in 76.5% of cases.…”

Section: Discussionmentioning

confidence: 79%

“…None of our four centers involved in this study has yet had extemporaneous histological examination. In addition, the tumors in our practice settings are large as in most cases reported in the African literature 6,17,30 . Also, the dermatofibrosarcoma of Darier and Ferrand is known to have macroscopically invisible filiform pseudopodia that may extend several centimeters beyond the palpable limit of the tumor 17,24 .…”

Section: Discussionmentioning

confidence: 91%

“…Surgery is the mainstay of treatment for dermatofibrosarcoma and remains the greatest provider of cure 16,22 . Four surgical procedures have been described in the literature 17,18,22 . These are: resection‐suture, resection‐healing by secondary intention, resection‐flap covering and resection‐skin grafting preceded or not by a first phase of healing by secondary intention 18,23–25 .…”

Section: Discussionmentioning

confidence: 99%

“…Dermatofibrosarcoma has diagnostic and therapeutic peculiarities in the African setting. In West African countries, diagnosis is late and tumor sizes are large 6,7,17 . Resections usually leave large wounds without the possibility of direct suture 6,18 .…”

Section: Introductionmentioning

confidence: 99%

“…In West African countries, diagnosis is late and tumor sizes are large. 6,7,17 Resections usually leave large wounds without the possibility of direct suture. 6,18 Oncoplastic surgery is increasingly used to cover the skin by mobilization of flaps.…”

Section: Introductionmentioning

confidence: 99%

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Dermatofibrosarcoma protuberans surgery: Experiences of four African surgical oncology units and literature review

Zongo

Guigemdé

Yameogo

et al. 2022

Journal of Surgical Oncology

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Background and Objectives Dermatofibrosarcoma is a locally malignant tumor. This gives surgery a place of choice. The advent of imatinib has improved outcomes. Our aim is to describe the indications, techniques and results of surgery. Methods A retrospective, multicenter, descriptive study conducted in four West African surgical oncology units. It covers dermatofibrosarcoma surgery performed between January 1, 1988 and December 31, 2020. We took into account the surgical procedure, the mode of skin coverage, adjuvant treatments and survival. Comparisons were possible using Student's t‐test and Pearson's χ2. Results We recorded 81 cases of dermatofibrosarcoma. Surgery was effective in 90.1% of cases. Wide resection was the principle with a mean resection margin of 3.8 ± 1.9 cm. healing by primary intention, flaps and healing by secondary intention were the methods of skin coverage in 30.1%, 24.7% and 41.1% respectively. The type of skin coverage was related to the topography and size of the tumor (p < 0.0001). The healing time is associated with the type of skin cover. The recurrence rate was not related to the type of skin coverage (p = 0.8). Conclusions Wide and deep resection in the absence of Mohs micrographic surgery ensures healthy margins. Oncoplasty reduces the healing time without increasing the risk of recurrence.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Dermatofibrosarcoma protuberans surgery: Experiences of four African surgical oncology units and literature review

Zongo

Guigemdé

Yameogo

et al. 2022

Journal of Surgical Oncology

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Dermatofibrosarcoma protuberans：clinical and pathological analysis of Asian samples from one center experience.

Peng

Lü

Huang

et al. 2023

Preprint

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Background：Dermatofibrosarcoma protuberans（DFSP）is one of rare and low-grade fibrohistiocytic tumor with malignant potential biological behavior. With the pathological character of the finger-like lesion invading soft tissues, DFSP is considered to be high rate of local recurrence. Method: In this study, we reported a retrospective study of 17 DFSP patients with surgery medical history and long-time follow-up period. All the cases were reviewed by research group with the clinical features, operation outcomes and pathological parameters. Results: 17 Asian patients were included in this study (the mean age is 41.82 years old with 9 females and 8 males). Location of DFSP are the belly (7/17 41.2%), the chest（2/17 11.8%）,the shoulder(5/17 29.4%), the face(1/17 5.9%), the perineum（1/17 5.9%） and the right leg（1/17 5.9%）. 6 cases were closed by plastic surgical suture（35.29%），3 cases by full thickness skin graft（17.65%）and 8 cases by pedicled flap（47.06%）. CD34 and Vimentin positively is 100%, 90% respectively. Desmin and S-100 negatively were 100%. The median value of Ki-67 is 12%. Conclusion: The challenge of DFSP is clinical local control after operation. The first choice of DFSP treatment is surgery with the aim of clear margin and properly reconstruction. For the clinical practice, Enhancing the clinical recognition of DFSP in the initial medical visit is important for proper management and operation opportunity.

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Darier and Ferrand's dermatofibrosarcoma: A carcinologic and cosmetologic challenge in a low-income country

Cited by 2 publications

References 14 publications

Dermatofibrosarcoma protuberans surgery: Experiences of four African surgical oncology units and literature review

Dermatofibrosarcoma protuberans surgery: Experiences of four African surgical oncology units and literature review

Dermatofibrosarcoma protuberans：clinical and pathological analysis of Asian samples from one center experience.

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