Darier′s disease in gastric malignancy: An unusual paraneoplastic phenomenon

Abstract

Darier's disease is an autosomal dominant genodermatosis resulting from ATP2A2 gene mutation. A 62-year-old male presented at our outpatient (OPD) with sudden-onset numerous dirty, warty papules over the head, neck, and back since 2 months. Histopathology of the skin lesions revealed acantholytic dyskeratosis suggestive of Darier's disease. He was referred to the gastroenterology department for some gastrointestinal (GI) symptoms where he was diagnosed with adenocarcinoma of the stomach and was subsequently operated. On his next visit to our department for follow-up, we found a marked diminution of the skin lesions in the absence of any specific treatment. In view of the above finding, we concluded that paraneoplastic dermatosis in the form of Darier's disease occurred in this patient. Paraneoplastic Darier's disease with gastric adenocarcinoma is not yet described in dermatology literature and is hence reported here.

Acquired Darier disease in a patient with metastatic prostate cancer: a paraneoplastic process?

“…One report describes a gastric malignancy presenting with Darier disease in a 62-year-old man. The cutaneous manifestations diminished on treating the underlying malignancy [6]. The second report A Table1.…”

Erythrodermic Darier disease associated with metastatic lung adenocarcinoma

“…We present a patient with erythrodermic DD in the context of advanced lung adenocarcinoma with pleural metastases. Previous reports of paraneoplastic DD are exceedingly rare and have been documented only as acquired conditions in association with gastric adenocarcinoma [3] and undifferentiated metastatic carcinoma [4]. This case report describes a paraneoplastic erythrodermic flare of underlying DD, with improvement of the patient's dermatologic condition in the course of chemotherapy and topical corticosteroid treatment.…”

Darier's Disease Appearing as Pityriasis Amiantacea

“…Association of Darier's disease with malignancy has rarely been reported 4 5 . Cases with underlying Hodgkin's lymphoma 4 and stomach cancer 5 are known.…”

“…Association of Darier's disease with malignancy has rarely been reported 4 5 . Cases with underlying Hodgkin's lymphoma 4 and stomach cancer 5 are known. It is hypothesised that cancer-producing cytokines such as transforming growth factor-β affecting cellular calcium homeostasis, lead to Darier's disease as a paraneoplastic syndrome 5 .…”

“…Cases with underlying Hodgkin's lymphoma 4 and stomach cancer 5 are known. It is hypothesised that cancer-producing cytokines such as transforming growth factor-β affecting cellular calcium homeostasis, lead to Darier's disease as a paraneoplastic syndrome 5 . In our case, skin manifestations preceded the oncologic manifestations, and did not correspond to any haematological malignancy (clinical course, or skin response to oncologic chemotherapy).…”