Dark adaptation compared with electrooculography in primary biliary cirrhosis

Abstract

In a series of asymptomatic patients with primary biliary cirrhosis there was a significant impairment of dark adaptation thresholds as compared with a control group. Vitamin A levels were abnormally low in only two of the patients and these two both showed high dark adaptation thresholds. The electrooculogram was reduced in only the most severely affected case. It is suggested that visual function tests should be performed alongside vitamin A level measurements before deciding on treatment.

Zinc and Liver Disease

“…Impaired night vision has been recognized in alcoholic cirrhotics since the late 1930s, and this has been confirmed in recent studies in many types of cirrhosis 39 – 41 . This is usually associated with vitamin A deficiency, and vitamin A supplementation improved night vision.…”

Dark adaptation in vitamin A-deficient adults awaiting liver transplantation: improvement with intramuscular vitamin A treatment

“…Underperception of night blindness has been reported by others in ALD,13 PBC14 24 and also in malnutrition. Our study confirmed underperception of impairment of DA which is a risk to patient safety.…”

“…Underperception of impaired DA has been reported in ALD and primary biliary cirrhosis (PBC) 13 14. Lack of perception of impairment is a risk to patient safety.…”

Dark adaptation in early primary biliary cirrhosis

“…Ten female PBC patients, with a mean (± SEM) age of 62.8 ± 3.2 (range 45-74) years and diagnosed 7.8 ± 1.7 (0. [8][9][10][11][12][13][14] years previously, were asked to participate in the study. The mean duration of symptomatic disease was 9.4 ± 1.8 (2.3-14.8) years.…”