DART‐MS for rapid, preliminary screening of urine for DMAA

Lesiak, Ashton D.; Adams, Kendra J.; Domin, Marek; Henck, Colin; Shepard, Jason R. E.

doi:10.1002/dta.1540

Cited by 35 publications

(21 citation statements)

References 39 publications

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“…The occurrence of DMAA in various concentrations related to the amount of the geranium extract contained in the dietary supplements has been positively confirmed . However, the real origin of DMAA in supplements labeled “containing geranium extract” has been still unidentified.…”

Section: Introductionmentioning

confidence: 93%

Enantiomeric separation of 1,3‐dimethylamylamine by capillary electrophoresis with indirect UV detection using a dual‐selector system

et al. 2015

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The CE method employing an indirect UV detection for the enantioseparation of 1,3-dimethylamylamine (DMAA), widely used in various preworkout and dietary supplements labeled as a constituent of geranium extract has been developed. The dual-selector system consisting of negatively charged sulfated α-CD (1.1% w/v) and sulfated β-CD (0.2% w/v) in 5 mM phosphate/Tris buffer (pH 3.0) containing the addition of 10 mM benzyltriethylammonium chloride (BTEAC) as the chromophoric additive was used for the enantiomeric separation of DMAA stereoisomers with the LODs in the range of 7.82-9.24 μg/mL. The method was partly validated and applied for the determination of the stereoisomeric composition of DMAA in commercial dietary supplements to verify the potential natural origin of DMAA.

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Section: Introductionmentioning

confidence: 93%

Enantiomeric separation of 1,3‐dimethylamylamine by capillary electrophoresis with indirect UV detection using a dual‐selector system

et al. 2015

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“…A primary analytical focus in toxicology is determining the presence or absence of drug metabolites in biological samples. Several studies have used DART‐MS to screen urine for metabolites of illegal drugs or drugs banned as dopants (Cody & Laramee, ; Blackledge, ; Gross & Caprioli, ; Gomez‐Rios & Pawliszyn, ; Lesiak et al, ). A common technique for isolating metabolites from urine is solid‐phase microextraction (SPME).…”

Section: Toxicology and Drug Metabolitesmentioning

confidence: 99%

Direct analysis in real time—Mass spectrometry (DART‐MS) in forensic and security applications

Pavlovich

Musselman²,

Hall

2016

Mass Spectrometry Reviews

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Over the last decade, direct analysis in real time (DART) has emerged as a viable method for fast, easy, and reliable "ambient ionization" for forensic analysis. The ability of DART to generate ions from chemicals that might be present at the scene of a criminal activity, whether they are in the gas, liquid, or solid phase, with limited sample preparation has made the technology a useful analytical tool in numerous forensic applications. This review paper summarizes many of those applications, ranging from the analysis of trace evidence to security applications, with a focus on providing the forensic scientist with a resource for developing their own applications. The most common uses for DART in forensics are in studying seized drugs, drugs of abuse and their metabolites, bulk and detonated explosives, toxic chemicals, chemical warfare agents, inks and dyes, and commercial plant and animal products that have been adulterated for economic gain. This review is meant to complement recent reviews that have described the fundamentals of the ionization mechanism and the general use of DART. We describe a wide range of forensic applications beyond the field of analyzing drugs of abuse, which dominates the literature, including common experimental and data analysis methods. © 2016 Wiley Periodicals, Inc. Mass Spec Rev 37:171-187, 2018.

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“…Test methods complementary to conventional GC‐ or LC‐MS(/MS) methodologies were presented employing ‘direct analysis in real time’ (DART) MS. Both dietary supplements as well as urine samples collected after ingestion of DMAA‐containing products were analyzed by means of DART MS with (LLE or SEP) and without sample preparation . With this method DMAA was identified in neat post‐administration urine samples collected up to 48 h, but in the absence of any method characterization, the detection limit, robustness, etc .…”

Section: Stimulantsmentioning

confidence: 99%

Annual banned‐substance review: analytical approaches in human sports drug testing

Thevis

Kuuranne

Geyer

et al. 2014

Drug Testing and Analysis

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Within the mosaic display of international anti-doping efforts, analytical strategies based on up-to-date instrumentation as well as most recent information about physiology, pharmacology, metabolism, etc., of prohibited substances and methods of doping are indispensable. The continuous emergence of new chemical entities and the identification of arguably beneficial effects of established or even obsolete drugs on endurance, strength, and regeneration, necessitate frequent and adequate adaptations of sports drug testing procedures. These largely rely on exploiting new technologies, extending the substance coverage of existing test protocols, and generating new insights into metabolism, distribution, and elimination of compounds prohibited by the World Anti-Doping Agency (WADA). In reference of the content of the 2014 Prohibited List, literature concerning human sports drug testing that was published between October 2013 and September 2014 is summarized and reviewed in this annual banned-substance review, with particular emphasis on analytical approaches and their contribution to enhanced doping controls.

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DART‐MS for rapid, preliminary screening of urine for DMAA

Cited by 35 publications

References 39 publications

Enantiomeric separation of 1,3‐dimethylamylamine by capillary electrophoresis with indirect UV detection using a dual‐selector system

Enantiomeric separation of 1,3‐dimethylamylamine by capillary electrophoresis with indirect UV detection using a dual‐selector system

Direct analysis in real time—Mass spectrometry (DART‐MS) in forensic and security applications

Annual banned‐substance review: analytical approaches in human sports drug testing

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