Das enteropathische hämolytisch-urämische Syndrom in der Pädiatrie: Ätiologie und Pathogenese

Zimmerhackl, L. B.; Garz, C.; Böhm, N.; Brandis, M.

doi:10.1007/978-3-642-80327-7_3

Cited by 4 publications

(4 citation statements)

References 10 publications

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“…However, the mechanism that leads to acute renal failure is not clear. Recent studies have demonstrated a direct toxic effect of Stx on renal epithelial cells in culture [39][40][41]. In these studies Stx induced apoptosis in cultured renal cell lines.…”

Section: Mechanisms Of Toxicitymentioning

confidence: 99%

“…In these studies Stx induced apoptosis in cultured renal cell lines. The mechanism transducing the apoptotic signal mediated by Stx binding is not understood [39,42]. In the pathogenesis of Stx-induced HUS several questions remain unanswered: how does the endothelial injury occur, is the platelet involvement primary or secondary [43]; what is the role of renal tubular cell damage, does it initiate or contribute to a cascade of events leading to endothelial cell damage [42]?…”

Section: Mechanisms Of Toxicitymentioning

confidence: 99%

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Enterohemorrhagic Escherichia coli infections: following transmission routes

Verweyen

Karch

Brandis

et al. 2000

Pediatric Nephrology

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Infections with enterohemorrhagic Escherichia coli (EHEC) are the major cause of hemolytic-uremic syndrome (HUS), the most-common cause of acute renal failure in childhood. The mortality rate of HUS (0%-5% in most recent series and 10%-30% in individual reports) and residual chronic renal sequelae (in up to 50% of patients in long-term follow-up studies) emphasize the seriousness of HUS for public health. Several studies have described possible sources of EHEC infection. However, in the majority of cases the pathogen cannot be identified in food or animals and the routes of transmission remain unclear. In this review article the hypothesized routes of transmission are summarized. The medical data bases "Medline" and "Current contents" were screened for the years January 1966 through November 1998. The difficulties in following the chain of EHEC infection are discussed. A precise evaluation of the environmental aspects of the patient is a precondition for further analysis.

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Section: Mechanisms Of Toxicitymentioning

confidence: 99%

Section: Mechanisms Of Toxicitymentioning

confidence: 99%

Enterohemorrhagic Escherichia coli infections: following transmission routes

Verweyen

Karch

Brandis

et al. 2000

Pediatric Nephrology

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“…In view of the different courses of HUS, a minimum of three different pathogenetic types which lead to HUS are subdivided. HUS caused by infection, idiopathic HUS (non-Shiga toxin HUS), and HUS in systemic diseases and after toxin exposure [87].…”

Section: Hemolytic-uremic Syndrome (Hus)mentioning

confidence: 99%

Therapeutic apheresis in nephrology

Bambauer¹,

Bambauer²,

Latza³

et al. 2014

Clin Nephrol Urol Sci

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Therapeutic plasma exchange (TPE) with hollow fiber modules is used in different severe diseases since more than 35 years. Based on many years of experience with the extracorporeal circulation in end-stage renal disease, the authors try to give an overview of therapeutic apheresis (TA) in renal diseases. The updated information on immunology and molecular biology of different renal diseases are discussed in relation to the rationale for apheresis therapy and its place in combination with other modern treatments. The different renal diseases can be treated by various apheresis methods such as TPE with substitution solution, or with online plasma or blood purification using adsorption columns which contain biological or non biological agents. The following diseases are discussed: rapidly progressive glomerulonephritis (RPGN) including anti-glomerular basement membrane antibody glomerulonephritis (anit-GBM RPGN), RPGN with or without glomerular deposition (ANCA-ab), pauci-immune RPGN, immune complex nephritis (ICN), and various glomerulonephritis with nephrotic syndrome (NS), hemolytic-uremic syndrome (HUS), myoglobulinemic renal failure, acute kidney injury (AKI), and kidney transplant rejection. For the renal diseases which can be treated with TA the guidelines of the Apheresis Applications Committee (AAC) of the American Society for Apheresis (ASFA) are cited.

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“…Die Erreger sind heute weltweit als Ursache verschiedener intestinaler Erkrankungen unterschiedlichen Schweregrades bekannt, mit zum Teil sich anschließenden postinfektiösen Erkrankungen wie das hämolytisch-urämische Syndrom (HUS) oder die thrombozytopenische Purpura (TTP) (Zimmerhackl et al, 2002 (Anonymus, 2000).…”

Section: Introductionunclassified

Nachweis Shigatoxin-bildender / Enterohämorrhagischer Escherichia coli (STEC / EHEC) mittels Real-Time PCR

et al. 2007

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Abkürzungen: DNA = Deoxyribonucleic acid; dNTP = desoxy-Nukleosidtriphosphate; EHEC = Enterohämorrhagische Escherichia coli; LFGB = Lebensmittel-und Futtermittelgesetzbuch; PCR = Polymerase Chain Reaction; STEC = Shigatoxin-bildende Escherichia coli.Zusammenfassung: Enterohämorraghische Escherichia coli (EHEC) zählen in Deutschland zu einer der bedeutendsten Ursachen bakterieller gastrointestinaler Lebensmittelinfektionen. Aufgrund der Möglichkeit des Auftretens postinfektiöser Syndrome, die vor allem bei Kleinkindern zu schweren organischen Schäden bis hin zum Tod führen können und der sehr geringen Infektionsdosis, darf der Erreger in 25 g verzehrsfertigem Lebensmittel nicht nachweisbar sein.Die gemäß der Amtlichen Sammlung nach § 64 Lebensmittel-und Futtermittelgesetzbuch (LFGB) vorgeschriebene PCRMethode und ein Real-Time-PCR-Verfahren wurden miteinander zuerst für den Nachweis isolierter DNA und danach mit Routineproben aus der human-bzw. veterinärmedizinischen sowie aus der Wasser-bzw. Lebensmitteldiagnostik verglichen.Das Real-Time-PCR-Verfahren zeichnete sich in beiden Untersuchungen durch eine höhere Sensitivität aus; allerdings konnte der für eine lebensmittelrechtliche Beurteilung notwendige kulturelle Keimnachweis nicht bei allen in der Real-Time-PCR positiven Proben geführt werden.Abstract: Enterohaemorrhagic Escherichia coli (EHEC) are among the most important bacterial causes of food-borne gastrointestinal infections in Germany. Because of the occurrence of post-infectious syndromes leading to severe organic damages and even death particularly among children, and with respect to the very low infection dose, EHEC may not be present in 25 g of consumable food.In this study, the PCR method enlisted in the Official Collection of Methods established pursuant to Article 64 of the German Food and Feed Law (Lebensmittel-und Futtergesetzbuch, LFGB) and a real-time PCR procedure were compared regarding their diagnostic outcome using both isolated DNA and routine samples (sent in for human and/or veterinary microbiological diagnostics as well as for environmental water and/or food diagnostics).The real-time PCR procedure showed a higher sensitivity in both diagnostic settings. A positive result by bacterial culture, however, which is needed for an assessement according to the Food and Feed Law regulations was not achieved in all real time-PCR positive probes.

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Das enteropathische hämolytisch-urämische Syndrom in der Pädiatrie: Ätiologie und Pathogenese

Cited by 4 publications

References 10 publications

Enterohemorrhagic Escherichia coli infections: following transmission routes

Enterohemorrhagic Escherichia coli infections: following transmission routes

Therapeutic apheresis in nephrology

Nachweis Shigatoxin-bildender / Enterohämorrhagischer Escherichia coli (STEC / EHEC) mittels Real-Time PCR

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