Natural History of Cholelithiasis The natural history of cholelithiasis, further subdivided into cholecystolithiasis and choledocholithiasis, is essentially influenced by the incidence of symptoms and complications, the size and localization of the gallstones, certain conditions which bear an increased risk for developing gallbladder cancer, and various exogenous factors such as rapid weight loss, eating habits and physical activity. 60–80% of the patients with gallbladder stones remain asymptomatic during their disease course. Per year, about 2–4% of these asymptomatic patients will suffer from episodes of acute biliary pain within 10 years after the first diagnosis of gallbladder stones, afterwards the yearly rate of acute biliary pain drops to 1–2%. Complications from gallbladder stones occur ten times less frequently than symptoms. Compared to gallbladder stones, little is known about the natural history of bile duct stones. The first diagnosis of common bile duct stones is frequently not made because of acute biliary pain, but because of common bile duct-related complications such as jaundice, cholangitis or pancreatitis.