Das Göttinger Miniaturschwein als Versuchstier

Beglinger, R; Becker, Marc; Eggenberger, E.; Lombard, C.

doi:10.1007/bf01971385

Cited by 34 publications

(7 citation statements)

References 15 publications

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“…The laboratory animals were eight healthy, full-grown minipigs (Göttingen Minipig®) [ 22 ], aged 24 to 30 months. In addition to the already described similarities in bone physiology, they show good postoperative healing assets and a high indolence after surgery [ 23 ]. All animals used in this study were specifically bred for laboratory animal use (Ellegaard Göttingen Minipigs A/S, Denmark).…”

Section: Methodsmentioning

confidence: 97%

Accuracy of Bone Measurements in the Vicinity of Titanium Implants in CBCT Data Sets: A Comparison of Radiological and Histological Findings in Minipigs

Gröbe

Semmusch

Schöllchen

et al. 2017

BioMed Research International

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Purpose The aim of this animal study was the determination of accuracy of bone measurements in CBCT (cone-beam computed tomography) in close proximity to titanium implants. Material and Methods Titanium implants were inserted in eight Göttingen minipigs. 60 implants were evaluated histologically in ground section specimen and radiologically in CBCT in regard to thickness of the buccal bone. With random intercept models, the difference of histologic measurements and CBCT measurements of bone thickness was calculated. Results The mean histological thickness of the buccal bone was 5.09 mm (CI 4.11–6.08 mm). The four raters measured slightly less bone in CBCT than it was found in histology. The random effect was not significant (p value 1.000). Therefore, the Intraclass Correlation Coefficient (ICC) was 98.65% (CI 100.00–96.99%). Conclusion CBCT is an accurate technique to measure even thin bone structures in the vicinity of titanium implants.

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Section: Methodsmentioning

confidence: 97%

Accuracy of Bone Measurements in the Vicinity of Titanium Implants in CBCT Data Sets: A Comparison of Radiological and Histological Findings in Minipigs

Gröbe

Semmusch

Schöllchen

et al. 2017

BioMed Research International

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“…The anatomical conditions like size, structure and functions of the heart of the Goettingen minipig approach those of humans allowing a transfer of the animal results obtained. The size of veins and coronary artery in these pigs are ideal for coronary artery surgery [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Accelerated intimal hyperplasia in aortocoronary internal mammary vein grafts in minipigs

Popov

Dörge

Hinz

et al. 2008

J Cardiothorac Surg

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Background: More than 50% of aortocoronary saphenous vein grafts are occluded 10 years after surgery. Intimal hyperplasia is the initial critical step in the progression toward occlusion. Internal mammary veins, which are physiologically prone to less hydrostatic pressure, may undergo an accelerated progression to intimal hyperplasia and thus be suitable for investigation of the mechanisms of aortocoronary vein graft disease.

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“…Fifty four minipigs (46 9, 8 d) were used with an average age of 49 (36-71) days and a mean weight of 3.2 (2.23-4.95) kg. The animals were raised at the Institute for Veterinary Hygiene of the University of Zürich (3). At age 3 weeks they were weaned from the mother and transferred to our laboratory where they stayed for a further 2 weeks.…”

Section: Animals and Sample Collectionmentioning

confidence: 99%

Reference Values of Various Blood Constituents in Young Minipigs

Brechbühler¹,

Kaeslin²,

Wyler³

1984

Clinical Chemistry and Laboratory Medicine

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In the Göttinger minipig, the reference values of 18 parameters in whole blood or plasma were determined. The results are expressed both äs the mean value and ± 2 SD presuming a symmetrical normal distribution and äs the median value with the corresponding ränge. For jpost blood constituents, the results of the two modes of calculation were similar. Comparison of the values from young minipigs with those from children shows that these animals are well suited in this respect for experimental work related tp human medicine. Referenzwerte verschiedener Blutbestandteile beim jungen MiniaturschweinZusammenfassung: Beim Göttinger Miniaturschwein wurden die Referenzwerte für 18 Kenngrößen im Vollblut oder Plasma ermittelt. Die Berechnungen erfolgten einerseits unter der Annahme einer symmetrischen Normalverteilung, andererseits als Medianwert und Angabe der Extremwerte. Bei den meisten Bestandteilen stimmen die Ergebnisse der beiden Berechnungsarten gut überein.Der Vergleich der Werte von jungen Miniaturschweinen mit den entsprechenden Referenzwerten bei Kindern zeigt, daß diese Versuchstiere für viele humanmedizinische Untersuchungen geeignet sind.

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Das Göttinger Miniaturschwein als Versuchstier

Cited by 34 publications

References 15 publications

Accuracy of Bone Measurements in the Vicinity of Titanium Implants in CBCT Data Sets: A Comparison of Radiological and Histological Findings in Minipigs

Accuracy of Bone Measurements in the Vicinity of Titanium Implants in CBCT Data Sets: A Comparison of Radiological and Histological Findings in Minipigs

Accelerated intimal hyperplasia in aortocoronary internal mammary vein grafts in minipigs

Reference Values of Various Blood Constituents in Young Minipigs

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