Das Mini-Erythrozyten-Aggregometer: Ein neues Gerät zur schnellen Quantifizierung des Ausmaßes der Erythrozyten-aggregation Mini Erythrocyte Aggregometer: A New Apparatus for Rapid Quantification of the extent of Erythrocyte Aggregation

Kiesewetter, H.; Radtke, H.; Schneider, R; Mussler, K.; Scheffler, A; Schmid‐Schönbein, H.

doi:10.1515/bmte.1982.27.9.209

Cited by 87 publications

(13 citation statements)

References 10 publications

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“…The viscosity was calculated from 200 single measurements taken over this period. Erythrocyte aggregation was measured applying the MiniAggregometer (Myrenne GmbH, Roetgen, Germany) [18].…”

Section: Methodsmentioning

confidence: 99%

Changes of Hemorheological and Biochemical Parameters after Plasma Perfusion Using a Tryptophan-Polyvinyl Alcohol Adsorber Leading to Clinical Improvement in Patients Suffering from Maculopathy

Widder¹,

Brunner²,

Engels³

et al. 1998

Blood Purif

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Background: Selective adsorption is an extracorporeal treatment able to reduce high-molecular-weight proteins and lipids. We evaluated its efficacy in lowering hemorheological parameters to achieve a better microcirculation of the retina. Patients and Methods: Ten patients suffering from maculopathies of various origin underwent a selective plasma adsorption procedure using the TR-350. Plasma and whole blood viscosity, erythrocyte aggregation and proteins and lipids were determined before and 24 h after therapy. Results: Selective adsorption therapy reduced the high-molecular-weight proteins and lipids. Plasma viscosity, standardized whole blood viscosity and erythrocyte aggregation were significantly lowered to 87, 88 and 65%, respectively, of their values prior to treatment. An improvement of visual acuity was achieved in 6/10 patients. Minor side effects were noted in 2/10 patients. Conclusions: Selective adsorption using the TR-350 adsorber is a safe technique, showing a high impact on blood rheology. The changes of hemorheological parameters led to clinical improvement in 6/10 patients suffering from retinal disorders.

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“…The viscosity was calculated from 200 single measurements taken over this period. Erythrocyte aggregation was measured applying the MiniAggregometer (Myrenne GmbH, Roetgen, Germany) [18].…”

Section: Methodsmentioning

confidence: 99%

Changes of Hemorheological and Biochemical Parameters after Plasma Perfusion Using a Tryptophan-Polyvinyl Alcohol Adsorber Leading to Clinical Improvement in Patients Suffering from Maculopathy

Widder¹,

Brunner²,

Engels³

et al. 1998

Blood Purif

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“…The hematocrit was determined with an hematocrit centrifuge. Eryth rocyte aggregation was measured using the hematocriterythrocyte-disaggregation appliance HEDA 1 (manu factured by Rheomed, Germany) [17], First, the eryth rocytes were separated at dispersion rates of 500/s. The reproducible decline in optical density observed in the standing blood after halting the dispersion is caused by a renewed aggregation of the erythrocytes.…”

Section: Methodsmentioning

confidence: 99%

Influence of Low Molecular Weight Hydroxyethyl Starch (HES 40/0.5-0.55) on Hemostasis and Hemorheology

Treib

Haaß²,

Pindur³

et al. 1996

Pathophysiol Haemos Thromb

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Hydroxyethyl starch (HES) with a high or medium molecular weight (MW) and a high degree of substitution is difficult to degrade and leads to an accumulation of large molecules. These molecules have a negative effect on hemostasiological parameters. In 10 patients with cerebrovascular diseases, a hemodilution therapy was carried out with low MW HES for 10 days. Due to the low MW of the HES used (56-61 kD), the rheological parameters erythrocyte aggregation and plasma viscosity were significantly lowered (p < 0.01). No coagulation parameters studied were affected beyond the dilution effect, which was measured using the decline in hematocrit. Low MW starch is a volume substitute that is well-suited for repeated infusion or hemodilution therapy, particularly for patients with increased hemorrhagic diathesis, because it does not affect hemostasis. The disadvantage of a relatively short volume effect can be compensated through a continuous infusion of a larger volume.

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“…Erythrocyte aggregation was measured in a Myrenne Mini Erythrocyte Aggregometer (MA-I, Myrenne GmbH, Roetgen, Germany) according to the method of Schmid-Schonbein [28]. Briefly, erythrocytes were washed in isotonic saline (0.9%) and the haematocrit adjusted to 35% with autologous plasma or serum.…”

Section: Haemorheological Methodsmentioning

confidence: 99%

Investigations into the haemorheological significance of postprandial and fasting hypertriglyceridaemia

Schütz

Schuff‐Werner

Guttner

et al. 1993

Eur J Clin Investigation

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Abstract. Two study designs were conceived to evaluate the rheological significance of hypertriglyceridaemia. We first investigated the course of serum-(SV) and plasma viscosity (PV) and erythrocyte aggregation in serum (SEA) and plasma (PEA) of healthy normolipidaemic individuals over 4 h after a fatty rich meal, in native material and after removal of triglyceride rich lipoproteins by centrifugation. Secondly, blood from patients with untreated hypertriglyceridaemia was investigated under fasting conditions. PEA and SEA increased in parallel with postprandial triglycerides (+ 135 mg dl-I), but the effect on PEA was more pronounced (+0.8 abs% increase; 2 h after the meal) as compared to SEA (+ 0.4 abs% increase). PV and SV increased in parallel to the same extent (+0.05 mPas). In the triglyceride poor infranatant no significant changes occurred. In fasting plasma PEA and PV were significantly lower (l.labs% and PV 0.04 mPas respectively) in infranatant than in native plasma, while only small differences in triglyceride (mostly VLDL) were observed. This phenomenon was barely detectable in serum samples.We conclude that triglyceride rich lipoproteins have a profound influence on haemorheological parameters, and that fibrinogen in particular, potentiates the effect of large fasting VLDL on plasma viscosity and erythrocyte aggregation.

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Das Mini-Erythrozyten-Aggregometer: Ein neues Gerät zur schnellen Quantifizierung des Ausmaßes der Erythrozyten-aggregation Mini Erythrocyte Aggregometer: A New Apparatus for Rapid Quantification of the extent of Erythrocyte Aggregation

Cited by 87 publications

References 10 publications

Changes of Hemorheological and Biochemical Parameters after Plasma Perfusion Using a Tryptophan-Polyvinyl Alcohol Adsorber Leading to Clinical Improvement in Patients Suffering from Maculopathy

Changes of Hemorheological and Biochemical Parameters after Plasma Perfusion Using a Tryptophan-Polyvinyl Alcohol Adsorber Leading to Clinical Improvement in Patients Suffering from Maculopathy

Influence of Low Molecular Weight Hydroxyethyl Starch (HES 40/0.5-0.55) on Hemostasis and Hemorheology

Investigations into the haemorheological significance of postprandial and fasting hypertriglyceridaemia

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