Das polyzystische Ovarsyndrom

Heutling, Dennis; Schulz, H; Randeva, Harpal S.; Dodt, Christoph; Lehnert, Hendrik

doi:10.1007/s00108-006-1776-7

Cited by 5 publications

(7 citation statements)

References 106 publications

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“…This is supported by the fact that progesterone sensitivity can be increased by the therapeutic use of flutamide, an androgen receptor antagonist. [4]…”

Section: Gonadotrophinsmentioning

confidence: 99%

“…Insulin resistance in PCOS leads to hyperinsulinemia, which increases androgen production in the ovaries. [4] Stimulation of theca cells by insulin means an additional trigger for androgen production. At the same time insulin decreases the production of SHBG in the liver, leading to increased levels of free active testosterone.…”

Section: Insulin and Steroid Hormone Metabolismmentioning

confidence: 99%

“…In 1921, French physicians Achard and Thiers found some coincidence between diabetes and hyperandrogenism when they coined the term ‘femmes à barbe diabetique’ (=diabetic women with beard). [4] The first systematic description mentioning amenorrhea, hirsutism, obesity, and polycystic ovaries was published by Irving Stein and Michael Leventhal, American gynecologists, in 1935. The so-called Stein-Leventhal-syndrome is a condition heavily influencing a woman’s reproductive abilities, as well as metabolic and cardiovascular health.…”

Section: Introductionmentioning

confidence: 99%

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Endocrinology of hirsutism

2010

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Hirsutism represents a primary clinical indicator of androgen excess. The most common endocrine condition causing hirsutism is polycystic ovary syndrome (PCOS). Diagnosing PCOS is not easy as the signs and symptoms are heterogenous. The newest diagnostic guideline made by the Androgen Excess and PCOS Society in 2006, claims the presence of hyperandrogenism, and ovarian dysfunction (oligo / anovulation and / or polycystic ovaries). Obesity associated reproductive and metabolic dysfunctions may aggravate the symptoms of PCOS. PCOS might be underdiagnosed in non obese women because lean PCOS phenotypes might be underestimated for the syndrome. Effective medical treatment of PCOS and associated hirsutism depends on the endocrinological expertise and experience of the therapist in each individual case. An algorithm for the treatment has not been established yet.

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“…This is supported by the fact that progesterone sensitivity can be increased by the therapeutic use of flutamide, an androgen receptor antagonist. [4]…”

Section: Gonadotrophinsmentioning

confidence: 99%

Section: Insulin and Steroid Hormone Metabolismmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Endocrinology of hirsutism

2010

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“…Bereits eine Gewichtsreduktion von 5% führt zu einer Senkung erhöhter Androgenspiegel und zu einer Verbesserung der ovariellen Funktion [8]. Während der Gewichtsreduktion hat die Nährstoffrelation der Diät keinen nennenswerten Einfluss auf die PCOS-relevanten Parameter [13,15].…”

Section: Ernährungstherapie Des Pcosunclassified

“…Ein groß-er Anteil davon weist bereits einen Typ-2-Diabetes (T2DM) auf. Sehr häufig ist bei PCOS-Patientinnen mit erhöhtem Bauchumfang ein HDL-Cholesterin von <50 mg/dl, Triglyzeride >150 mg/dl, ein Blutdruck >130/85 mmHg und ein Nüchternblutzucker >110 mg/dl nachzuweisen, was dem Vollbild eines 7 metabolischen Syndroms entspricht[8].Die beim PCOS typische Dyslipidämie -hohe Triglyzeride und niedriges HDL-Cholesterin -sind unabhängige Prädiktoren für eine koronare Herzerkrankung. Dieses typische 7 atherogene Lipidprofil beim MetS korreliert mit dem Ausmaß der IR.…”

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