Das Verhalten der Gerinnungsfaktoren bei hypoxischen Neugeborenen unter der Puffertherapie

Rogner, G; Maak, B.; Frenzel, J

doi:10.1007/bf00438901

Cited by 4 publications

(1 citation statement)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…

Summary 5,9,16,18,25,29). Some authors report changes consistent with

The effects of severe hypoxemia on blood coagulation factor activities and other physiologic parameters were examined in ten near-term chronically catheterized fetal lambs (135-140 days gestation).

…”

mentioning

confidence: 99%

Blood Coagulation Changes Following Hypoxemia in the Near-Term Fetal Lamb

1982

Pediatr Res

View full text Add to dashboard Cite

Summary 5,9,16,18,25,29). Some authors report changes consistent withThe effects of severe hypoxemia on blood coagulation factor activities and other physiologic parameters were examined in ten near-term chronically catheterized fetal lambs (135-140 days gestation). Six lambs were subjected to a mean Po2 of 13.8 + 1.4 mmHg for 60 min. The other four served as controls. Before, during and after hypoxemia, the white blood cell count, hemoglobin, hematocrit, platelet count, pH, Pcoz, Poz, mean arterial pressure, heart rate, norepinephrine and epinephrine were measured. Measures of coagulation factor activities including platelet counts, partial thromboplastin times, prothrombin times and quantitation of plasma activities for factors I, 11, V, VII, VIII, IX, X, XI, XII, fibrin degradation products (FDP), antithrombin 111, fibrin monomer and ristocetin cofactor activity were also done. An increase in mean arterial Dressure from 48 + 2 mmHg to 56 + 2 " mmHg, and an increase in epinephrine from 22 f 9 pg/dl to 419 2 199 pg/dl, and norepinephrine from 431 f 98 pg/dl to 2408 + 868 pg/dl occurred in-thehypoxemic animals. here was also a slight decrease in the pH from 7.37 + 0.01 to 7.32 + 0.03 in the hypoxemic animals. The only significant change in blood coagulation factors during hypoxemia was a slight increase in fibrin monomer from 5.6 f 0.8 p g / d to 12.6 + 2.0 pg/ml. After the experiment, the animals were allowed to go to term and deliver spontaneously. Delivery occurred from 2-12 days after the experiment (mean 6 days). Blood coagulation factor activities I, 11, V, VI1, VIII, IX, X, XI, XII, antithrombin 111, fibrin monomer, and fibrin degradation products were measured after delivery in the hypoxemic and control animals. Except for factor XII, values obtained from ten previously catheterized control fetal lambs after spontaneous delivery did not differ from the current control animals after delivery.Values on postdelivery samples for the two control groups were therefore pooled for analysis. Factors VIII, and IX were found to show increased activity during the 2 wk after delivery in hypoxemic animals when compared with controls. In contrast, the values for factors 11, V, VII, X and fibrinogen showed lower activity in hypoxemic as compared to control animals during the early neonatal period. The study demonstrates that though there are no severe acute effects on blood coagulation during severe hypoxemia in the near-term fetus except perhaps transient low-grade disseminated intravascular coagulation, the episode of hypoxemia appears to alter the future development of blood coagulation factor activities during the early neonatal period. SpeculationHypoxemia in the near-term fetus delays the normal development of prothrombin, factors V, VII, X, and fibrinogen during the early neonatal period and accelerates the development of factors VIII and IX. The differences in factor responses may help explain the variable results reported in human infants. The results also suggest that both thrombotic and hemorrhagic tendencies...

show abstract

“…

Summary 5,9,16,18,25,29). Some authors report changes consistent with

The effects of severe hypoxemia on blood coagulation factor activities and other physiologic parameters were examined in ten near-term chronically catheterized fetal lambs (135-140 days gestation).

…”

mentioning

confidence: 99%

Blood Coagulation Changes Following Hypoxemia in the Near-Term Fetal Lamb

1982

Pediatr Res

View full text Add to dashboard Cite

show abstract

The influence of perinatal risk factors on the incidence of atypical coagulation factor VII during the first days of life

Maak¹,

Frenzel²

1977

Eur J Pediatr

View full text Add to dashboard Cite

The correlation between the appearance of functionally-atypical factor VII and perinatal complications was investigated in 66 newborn infants. The presence of an abnormal clotting factor was assumed if the ratio between clotting activity and antigen-related factor VII material exceeded the normal range for adult plasma. The newborns were divided into a risk group of infants threatened by adverse conditions of labour or post-natal adaptation, and a control group of newborns without perinatal complications. The findings were as follows: The incidence of atypical factor VII was significantly higher in the risk group. There was no difference between prenatal and postnatal complications in this respect. Infants born by caesarian section or with cord complications, as well as those with delayed respiratory adaptation, showed a higher incidence of atypical factor VII than the risk group as a whole. Atypical factor VII was not detected until the third day of life, irrespective of the prenatal or postnatal complications. These findings suggest that perinatal risk factors are associated with an alteration of factor VII synthesis.

show abstract

Prothrombin in Newborns and During the First Year of Life

et al. 1971

View full text Add to dashboard Cite

The hypoprothrombinemia of the newborn was first demonstrated by Brinkhous et al. in 1937, by use of their two-stage prothrombin assay (5). Waddell and coworkers (41) were the first to associate the hypoprothrombinemia, expressed by a prolonged "prothrombin time" (34), with vitamin K deficiency. Several investigators (7,29,30,35) repor,ted that prothrombin decreased during the first few days of life and then increased to normal values within a week (35) or within a year (5, 6, 30), depending on the method used for the assays. It has been postulated that the postnatal decrease of prothrombin and related coagulation factors might be explained by a quick reduction of the transferred maternal factors combined with a slow synthesis of coagulation factors in the infant liver (16). Because of the potential bleeding risk in this age period vitamin K prophylaxis was introduced and a safe dosage established (1, 6, 10, 36).Studies of prothrombin and other coagulation factors in the newborn have resulted in some paradoxical findings. Thus the one stage "prothrombin time" according to Quick (34) gives normal values in newborns in spite of definitely subnormal activities of factors VII, X and prothrombin (factor II), assayed by specific methods. In adults the Quick test registers deficiencies of these factors. Several explanations have been offered: molecular dif-18 -712877 A c t 3 Padiat Scand 60 ferences between infant and adult prothrombin (30, 36) and fibrinogen (20, 42) or possibly an excess of factor V (11) in the newborn. It is evident that testing techniques used must always be taken into account when comparing coagulation assay results especially in this age In most Swedish hospitals "prothrombin index" according to 34) and the prothrombin-proconvertin assay according to Owren & Aas (31) have been replaced by thrombotest according to Owren (32) as the latter test is performed with a readymade, freeze-dried reagent and is well standardized. The Quick-Lehmann test registers deficiencies of factors 11, V, VII, X as well as fibrinogen (factor I), but with varying sensitivity. The prothrombin-proconvertin and the thrombotest reagents contain bovine fibrinogen and factor V, and the methods register deficiencies of vitamin K dependent coagulation factors, i.e. factors 11, VII and X, and the thrombotest to a certain extent also factor IX.The present investigation was undertaken to study a new specific two-stage assay of prothrombin (3, 28) in newborns. Further, the correlation between thrombdest activity and prothrombin concentration was studied, as well as prothrombin and proconvertin during the first year of life. The study was especially concerned with cases of decreased prothrombin Acta Pcediat Scand 60 group (1). 270 I. Nor& et al. 2.8, 2.6. 2.4-22-5 20.

show abstract

Das Verhalten der Gerinnungsfaktoren bei hypoxischen Neugeborenen unter der Puffertherapie

Cited by 4 publications

References 9 publications

Blood Coagulation Changes Following Hypoxemia in the Near-Term Fetal Lamb

Blood Coagulation Changes Following Hypoxemia in the Near-Term Fetal Lamb

The influence of perinatal risk factors on the incidence of atypical coagulation factor VII during the first days of life

Prothrombin in Newborns and During the First Year of Life

Contact Info

Product

Resources

About