Das Verhalten der intramuskulär, intravenös und per os verabreichten Gammaglobuline

Pan, R. Martin Du; Scheidegger, J J; Wenger, Paul Eugène Etienne; B, Koechli; Roux, Julie

doi:10.1007/bf01630314

“…Jouvenceaux [17] found that between 35 and 40% of intramuscularly injected gamma globulin doses were present in the plasma compartment 5-10 days after the injection. In these studies as well as in our 2 probands and in earlier experiments reported by Martin du Pan et al [22], the extent and the rate of resorption depended on the general status, the age and the muscular activity of the probands. The rate of resorption may also be influenced by the total amount of injected material: Smith et al [34] injected only 180 mg of anti-Rhesus immunoglobulin in a vol of 2m1, whereas our probands received 1,600mg in 1Oml.…”

Section: Discussionsupporting

confidence: 83%

In vivo Behaviour of Gamma Globulin Preparations¹

Morell¹,

Schürch²,

Ryser³

et al. 1980

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Metabolic properties of standard gamma globulin (St-GG) and of several gamma globulin (GG) preparations for intravenous use were analyzed in radioactive tracer studies. The in vivo behaviour of St-GG was investigated in 16 probands and found to be comparable to that of normal IgG. The kinetics of the resorption of St-GG from intramuscular deposits, its elimination from the intravascular compartment and from the body were studied in 2 probands. Metabolic properties of GG preparations for intravenous use were compared with those of St-GG in 3-4 probands after simultaneous injection of 125I- and 131I-labelled tracer doses. Important differences in the half-times of intravascular survival, in the rates of catabolism and in the distribution in the body were noticed for most of the preparations for intravenous use except for an improved acid-treated (pH 4) GG, the in vivo behaviour of which was similar to that of St-GG.

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“…Jouvenceaux [17] found that between 35 and 40% of intramuscularly injected gamma globulin doses were present in the plasma compart ment 5-10 days after the injection. In these studies as well as in our 2 probands and in earlier experiments reported by Martin du Pan et al [22], the extent and the rate of resorption depended on the general status, the age and the muscular activity of the pro bands. The rate of resorption may also be influenced by the total amount of injected material: Smith et al [34] injected only 180 mg of anti-Rhesus immunoglobulin in a voi of 2 ml, whereas our probands received 1,600 mg in 10 ml.…”

Section: In Vivo Behaviour Of Gamma Globulin Preparations For Intravesupporting

confidence: 82%

In vivo Behaviour of Gamma Globulin Preparations

Morell¹,

Schürch²,

Ryser³

et al. 1980

View full text Add to dashboard Cite

Metabolic properties of standard gamma globulin (St-GG) and of several gamma globulin (GG) preparations for intravenous use were analyzed in radioactive tracer studies. The in vivo behaviour of St-GG was investigated in 16 probands and found to be comparable to that of normal IgG. The kinetics of the resorption of St-GG from intramuscular deposits, its elimination from the intravascular compartment and from the body were studied in 2 probands. Metabolic properties of GG preparations for intravenous use were compared with those of St-GG in 3-4 probands after simultaneous injection of 125I- and 131I-labelled tracer doses. Important differences in the half-times of intravascular survival, in the rates of catabolism and in the distribution in the body were noticed for most of the preparations for intravenous use except for an improved acid-treated (pH 4) GG, the in vivo behaviour of which was similar to that of St-GG.

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“…This is illustrated in case 2 with positive skin test and side reactions following the use of gammaglobulin from one batch, but not from another. The amount of gammaglobulin that is rapidly absorbed probably varies from one injection to another (17), and this may partly explain the irregularity of the reactions.…”

Section: Discussionmentioning

confidence: 99%