The corpus of biomedical literature is growing rapidly as many papers are recorded in PubMed every day. These papers often contain high-quality biological pathways in their figures/text, which are great resources for studying biological mechanisms and precision medicine. However, it can take a long time for many of these works to be put into practical use as each paper's contributions need to be curated by experts. This, often lengthy, process causes professional practice to lag behind research. To speed up this process, I helped develop a pipeline that integrates NLP and object detection processing to extract gene relationships reported in articles' figures and text. This pipeline was able to extract such relationships with high precision and recall on a small, annotated set. However, extending this pipeline for improved generalization and new settings was limited by the number of high-quality annotations available. Such labeled data is very time consuming to collect and traditional augmentations were observed to generate diminishing returns. To address this shortcoming, I developed an approach for generating purely synthetic data for object detection on biological pathway diagrams based on a set of rules and domain knowledge. Our method iteratively generates each pathway relationship uniquely and is demonstrated to improve the generalization of our object detection model significantly across a variety of settings. Additionally, with the capability to generate unique and informative samples, we integrated our synthetic generation methodology into an active learning setting. While traditional active learning relies on a pool of unlabeled data to draw from with an acquisition function, our method is pool-less and does not require any acquisition function. Instead, we generate each batch of data uniquely based on the training losses from the previous batch. Pool-less Active Learning (PAL) via synthetic data generation is demonstrated to reduce the number of iterations required for model convergence during training on pathway figures.