An innovative approach for increasing the energy efficiency of Data Centers is discussed. This approach views Data Centers as active load resources, integrated in the context of the smart city and operated in a coordinated manner. Data Centers can thus contribute to establishing sustainable, local, energy management ecosystems on a smart city level, while enabling optimized operation of the involved energy grids. To that end, the development of local marketplaces will allow for trading surplus of energy, both electricity and thermal, and provide local balancing flexibility as ancillary services. Reinforcing this vision, innovative business models are proposed that enable next generation of smart Net-zero Energy Data Centers acting as energy prosumers at the interface with smart energy grids within a smart city environment. Simulation experiments are conducted using the GEYSER defined Data Centers flexibility models and non-linear optimization techniques. Such simulations are used to evaluate the Data Centers energy demand flexibility in meeting various network level goals.