The article reveals the content of Industry 4.0 technologies in the subsystems of international trade. The destructive type of innovations of the fourth industrial revolution on traditional spheres of trade is defined. The types of modern innovations related to the technologies of Industry 4.0 and form competitive advantages in successful global brands are identified and characterized, they are reviewed for the presence of common features inherent in its technologies and innovations in general. The influence of Industry 4.0 on the stages of introduction of the innovation process in international trade is analysed. It is established that at the stage of experimental implementation of innovations, omnichannel logistics, drones, and 3D printing have a high level of influence, which are trends in the miniaturization of the economy and the concept of «smart enterprise». An analysis of the impact of the trend of changes from Industry 4.0 innovations in international trade through the impact on consumer behavior and the functioning of business models of enterprises. The expediency of introduction of drones in the aspect of expansion of sales channels and receipt of goods on the basis of the omnichannel approach of increase of volumes of the international trade is proved. Existing and perspective spheres of application of drone logistics are analysed. A positive effect in terms of optimizing the cost of maintaining employees through the use of drones on the example of warehousing and fast delivery of goods to order. The problem of large-scale introduction of drones to exacerbate the issue of replacing workers in entire industries with artificial intelligence and the need to learn new professions is outlined. The influence of additive production on international trade by introduction of 3D printing technology is analysed, the spheres of its application and consequences of introduction are defined. The reality of the scenario forecast of development of 3D printing and its influence on subsystems of the international trade, chains of delivery of the goods, formation of stocks of raw materials and materials is considered. The possible consequences of the application of 3D printing technology for the field of intellectual property are described. It is proved that the key catalysts of Industry 4.0 at the level of international trade are innovations in the form of attracting drones to logistics supply and marketing systems and inventory optimization by expanding the scope of 3D reproduction techniques.