Data processing of 3D and 4D in-vivo electron paramagnetic resonance imaging co-registered with ultrasound. 3D printing as a registration tool

Gonet, Michał; Epel, Boris; Elas, Martyna

doi:10.1016/j.compeleceng.2019.01.012

Cited by 5 publications

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It means that if the spin probe administration is disturbed, it will be visible in the spatial image. Therefore, for precise localization of the tissue boundaries, EPRI should be supported by other anatomical imaging techniques such as MRI, CT, or US . Although the anatomical resolution of EPRI is far from the techniques mentioned above, the development of a new spin probe with a narrow EPR linewidth will improve the spatial resolution and provide more details of the spin probe biodistribution.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, for precise localization of the tissue boundaries, EPRI should be supported by other anatomical imaging techniques such as MRI, 19 CT, 52 or US. 53 Although the anatomical resolution of EPRI is far from the techniques mentioned above, the development of a new spin probe with a narrow EPR linewidth will improve the spatial resolution and provide more details of the spin probe biodistribution. Another limitation is the number of chemical manipulations that have to be employed for preparing the EPR spin probe.…”

Section: ■ Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Dynamic Electron Paramagnetic Resonance Imaging: Modern Technique for Biodistribution and Pharmacokinetic Imaging

Baranowski

Gonet

Czechowski³

et al. 2020

J. Phys. Chem. C

View full text Add to dashboard Cite

The imaging of the biodistribution and pharmacokinetics is critical in understanding the complexity of drug delivery mechanisms, the status of the disease, and the monitoring of the treatment progress. The imaging techniques, such as magnetic resonance imaging, computed tomography, and positron emission tomography, are suitable for clinical applications. However, with regards to the biodistribution and pharmacokinetics, their availability is often limited due to the requirements of ionizing radiation or high magnetic fields, low spatial and temporal resolution (applicable for animals), and high maintenance costs. Electron paramagnetic resonance (EPR) imaging is a technique that allows for the minimal invasive mapping of unique parameters, such as the oxygen concentration, the redox state, the thiol concentration, or the pH level, in vivo. In this work, a high temporal resolution 3D EPR imaging technique was used for assessing the trityl spin probe pharmacokinetics in mice. The results demonstrate the preliminary outcomes in the application of EPR imaging for the comparison of the trityl spin probe pharmacokinetics between that of a healthy mouse and a tumor-bearing mouse. This study will stimulate further investigation into the use of imaging strategies, such as EPR imaging, to analyze pharmacokinetics.

show abstract

Section: Discussionmentioning

confidence: 99%