Data Set for the Reporting of Oral Cavity Carcinomas: Explanations and Recommendations of the Guidelines From the International Collaboration of Cancer Reporting

Abstract

The International Collaboration on Cancer Reporting is a nonprofit organization whose goal is to develop evidence-based, internationally agreed-upon standardized data sets for each cancer site for use throughout the world. Providing global standardization of pathology tumor classification, staging, and other reporting elements will lead to the objective of improved patient management and enhanced epidemiologic research. Carcinomas of the oral cavity continue to represent a significant oncologic management burden, especially as changes in alcohol and tobacco use on a global scale contribute to tumor development. Separation of oral cavity carcinomas from oropharyngeal tumors is also important, as management and outcome are quite different when human papillomavirus association is taken into consideration. Topics such as tumor thickness versus depth of invasion, pattern of invasive front, extent and size of perineural invasion, and margin assessment all contribute to accurate classification and staging of tumors. This review focuses on the data set developed for Carcinomas of the Oral Cavity Histopathology Reporting Guide, with discussion of the key elements developed for inclusion.

Prognostic effect of perineural invasion in surgically treated esophageal squamous cell carcinoma

“…Thus, other methods, such as keratin or S‐100 protein detection, which has been implicated in colorectal carcinogenesis, may improve the accuracy of PNI detection 21 . When reporting the pathology of head and neck cancer, the presence of PNI is usually documented; 20,22,23 however, we suggest that it should also be documented for ESCC.…”

Occult Nodal Metastasis in Oral Cavity Cancers

“…Local regional recurrence, distant metastasis, and decreased survival have been consistently reported in association with the ECS in cervical lymph nodes. The pattern of invasion in OSCC should be reported as cohesive, noncohesive, or widely dispersive [8]. The presence of noncohesive invasive front and perineural invasion indicate a high risk of loco-regional relapse [9].…”

Impact of Planning Method (Conventional versus Virtual) on Time to Therapy Initiation and Resection Margins: A Retrospective Analysis of 104 Immediate Jaw Reconstructions

“…Infiltration of the bone correlates with a worse prognosis [ 74 ]. An oncologic safety margin of about 5 mm should be the aim for pathohistological classification of free margins status (R0) [ 9 ]. Therefore, excision was recommended at about a 10 mm distance around the palpable tumor [ 10 ] and 10 mm length to the visible tumor border in the bone.…”

“…Five-year survival rates of the progressed staged disease were estimated at 50–60% [ 3 ], and its pathohistological residual status (R-category) has been described in the literature as a prognostic factor for tumor recurrence [ 4 , 5 , 6 , 7 , 8 ]. Surgical therapy is aimed to excise the neoplasia with a surrounding safety margin of ≥5 mm (R0-resection) [ 9 ], corresponding to an intraoral distance of 10 mm to the palpable tumor border [ 10 ]. Further fixation and processing for pathohistological assessment distort measurements, due to tissue shrinkage and, therefore, changes concerning margin evaluation [ 11 ].…”