Data storage in sequence-defined macromolecules via multicomponent reactions

Boukis, Andreas C.; Meier, Michael

doi:10.1016/j.eurpolymj.2018.04.038

Cited by 91 publications

(76 citation statements)

References 33 publications

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“…With the development of various synthesis routes, applications such as information storage, biological mimicking, and anti‐counterfeiting technologies are now being explored. Interest in the area of coding and decoding data has grown and thus the ability to install numerous functional side groups on these macromolecules is certainly appealing as this is one way to increase the amount of encoding information . Most of these applications require monodisperse macromolecules, with a defined sequence order …”

Section: Methodsmentioning

confidence: 99%

Automated Synthesis Protocol of Sequence‐Defined Oligo‐Urethane‐Amides Using Thiolactone Chemistry

Holloway

Mertens

Prez

et al. 2018

Macromol. Rapid Commun.

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An automated, iterative protocol for the synthesis of multifunctional, sequence‐defined oligo‐urethane‐amides using thiolactone chemistry is reported. Here, sequenced functionalization of the backbone is easily introduced using commercially available primary amines. The chemistry is carried out on solid phase using different supports for better optimization of the synthetic protocol and in order to demonstrate the versatility of the approach. This technique is very effective for iterative synthesis and solid‐phase chemistry and enables the exploration of full automation of this approach using a robotic peptide synthesizer. As a result, this automated protocol allows for the synthesis of a sequence‐defined nonamer of high purity.

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Section: Methodsmentioning

confidence: 99%

Automated Synthesis Protocol of Sequence‐Defined Oligo‐Urethane‐Amides Using Thiolactone Chemistry

Holloway

Mertens

Prez

et al. 2018

Macromol. Rapid Commun.

View full text Add to dashboard Cite

show abstract

“…It thus appears attractive to exploit sequence-defined macromolecules as a medium for coding and decoding of information at the molecular level. [14] As important as storing data in a macromolecule is the readout of the stored information. Computers use a binary system to store data.…”

Section: Sequence Enables Data Storage With First Applications In Commentioning

confidence: 99%

“…[25] As a recent example, using synthetic sequence-defined peptides, specific solubilizers for a potential anti-Alzheimer disease drug were designed. Two recent examples of sequence-defined and data-storing macromolecules by Lutz and co-workers [21] (bottom) and Boukis and Meier [14] (top, right) demonstrating the feasibility and state-of-the-art of this concept. [27,28] Considerable efforts have been directed at the aim of precision naturally analogue nanoreactors, yet the employed macromolecules typically rest on reversible radical deactivation polymerization (RDRP) and thus feature an inherent dispersity as well as a variation in the placement of the catalytically active ligation units or binding sites that affect the folding.…”

Section: Sequence Leads To Properties and Materials Applications In Camentioning

confidence: 99%

A New Class of Materials: Sequence‐Defined Macromolecules and Their Emerging Applications

2019

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Emerging applications of a new class of materials, sequence‐defined macromolecules, are explored. Such molecularly highly defined macromolecules require stringent synthesis and purification procedures, yet offer unprecedented application possibilities. The first examples of molecular data storage and related technologies are already starting to emerge today. From a more fundamental point of view, such macromolecules offer a unique opportunity to determine quantitative structure–property relationships (QSPR), which critically aids in designing materials with applications ranging from catalysis to artificial enzymes.

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“…Furthermore, effective exploitation of this space requires use of multiple unique functional groups, making chemical implementation difficult; when only a few are used, most reaction mixtures result in uncontrolled polymerization or multiple products. Nevertheless, three‐component and even four‐component reactions have been investigated in IC processes resulting in highly functionalized uniform oligomers 27–29…”

Section: Functional Group Considerationsmentioning

confidence: 99%

Theoretical Aspects of Iterative Coupling for Linear Oligomers and Polymers

Neto

Jones

Wong

2020

Macro Theory & Simulations

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A conceptual study of iterative coupling (IC) is performed, providing a unified description and new research directions. IC chain growth rates and functional group choice are analyzed, guiding construction of efficient schemes. The concept of cycle efficiency is defined as a more complete metric of experimental implementations of IC, and then applied to the main linear and exponential IC processes. The mathematical relations between individual reactions, cycles, and the iterative process as a whole are studied. Finally, macromolecule IC is proposed as a strikingly complementary process to standard IC, with potential to reduce the dispersity of non‐uniform samples. Due to its connection with the central limit theorem of statistics, it provides an unusually robust, powerful, and general method for scalable production of polymer samples with narrow distribution. In all, this contribution assists development of improved IC processes targeting low dispersity linear oligomers and polymers.

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Data storage in sequence-defined macromolecules via multicomponent reactions

Cited by 91 publications

References 33 publications

Automated Synthesis Protocol of Sequence‐Defined Oligo‐Urethane‐Amides Using Thiolactone Chemistry

Automated Synthesis Protocol of Sequence‐Defined Oligo‐Urethane‐Amides Using Thiolactone Chemistry

A New Class of Materials: Sequence‐Defined Macromolecules and Their Emerging Applications

Theoretical Aspects of Iterative Coupling for Linear Oligomers and Polymers

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