Database tools in genetic diseases research

Abstract

The knowledge of the human genome is in continuous progression: a large number of databases have been developed to make meaningful connections among worldwide scientific discoveries. This paper reviews bioinformatics resources and database tools specialized in disseminating information regarding genetic disorders. The databases described are useful for managing sample sequences, gene expression and post-transcriptional regulation. In relation to data sets available from genome-wide association studies, we describe databases that could be the starting point for developing studies in the field of complex diseases, particularly those in which the causal genes are difficult to identify.

Study Human Genetics & Relations with complex diseases

“…Prospective methodology made the study of human genetics more reliable and the mechanism behind complex diseases is being more and more well investigated and discovered [2]. In another aspect, bioscience has reached a relatively high level in the trend of big data times [3]. From perspective of bioinformatics and computational genetics, theoretical frameworks and pipelines are becoming much more applicable and preferable for both biostatisticians and biologists to exploit since previous results are more than promising [4].…”

Functional, structural and epitopic prediction of hypothetical proteins of Mycobacterium tuberculosis H37Rv: An in silico approach for prioritizing the targets

“…Moreover, HPs may act as potential virulent factors which may be predicted by bioinformatics tools and targeted further for the structure based rational drug design [19][20][21][22][23]. It has already been known that bioinformatics tools including free online servers and databases are recently applicable tools used in the study of genomics and proteomics in human [24], animal [25] and microorganisms [26].…”

<p>Genomics and Transcriptomics: The Powerful Technologies in Precision Medicine</p>

“… 13 These improvements led to the advent of a new field in diagnosing and treating diseases as well as reducing healthcare costs. 14 – 16 This new field is called precision medicine ( Figure 1 ). A simple definition for precision medicine is a treatment designed for diseases that, unlike the conventional procedures, do not prescribe a common treatment for all people with the same disease.…”