Dataset of the phospholipidome and transcriptome of Campylobacter jejuni under different growth conditions

Abstract

The membrane phospholipid composition is not a stable bacterial characteristic but can change in response to altered environmental conditions. Here we provide the dataset of the phospholipidome and transcriptome of the microaerophilic human pathogen Campylobacter jejuni under different environmental conditions. These data have been used in Cao (2020), The unique phospholipidome of the enteric pathogen C. jejuni : Lysolipids are required for motility at low oxygen availability. Here the abundance of each phospholipid is shown during the growth of C. jejuni for 0-108 h under low and high oxygen conditions (0.3 vs 10% O 2 ). The phospholipid data were obtained by applying high performance liquid chromatography tandem-mass spectrometry (LC-MS/MS). The transcriptomic data obtained by RNA-seq show the differential expressed genes between logarithmic and stationary grown bacteria. In addition, our data might serve as a reference information for further in-depth investigation to understand the relation between specific phospholipids and the activity of membrane associated proteins.

Revisiting Campylobacter jejuni Virulence and Fitness Factors: Role in Sensing, Adapting, and Competing

“…Lysophospholipids are small bioactive lipid molecules characterized by a single carbon chain and a polar head group. It is hypothesized lysophospholipid allows C. jejuni to be motile under low O 2 conditions ( Cao et al., 2020a ). This is a significant observation considering the requirement of C. jejuni to adapt to the low oxygen deep in the mucus layer of the human GI tract.…”

Protein quality control modulates the metabolic conservation in antibiotic tolerantCampylobacter jejuni

“…A wide variety of LPLs were detected in C. jejuni, and the composition of these LPLs varied depending on environmental conditions. In particular, variations in oxygen levels can alter the composition of LPLs 83 . A previous study has shown that a high amount of LPLs is required for C. jejuni to maintain motility under oxygen-limited condition 83 .…”

“…In particular, variations in oxygen levels can alter the composition of LPLs 83 . A previous study has shown that a high amount of LPLs is required for C. jejuni to maintain motility under oxygen-limited condition 83 . Although the specific role of LPLs and their related mechanisms in bacterial stress response remain unclear, they are known to contribute to membrane curvature stress and stability, thereby affecting membrane permeability [84][85] .…”