Datura innoxia— a potential commercial source of scopolamine

Gerlach, George Henry

doi:10.1007/bf02859498

Cited by 11 publications

(3 citation statements)

References 46 publications

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“…However, its natural range is difficult to determine because it has become so widespread (Lester et al 1991). Datura is cultivated commercially in Central America, North Africa, Ethiopia, India, and England for pharmaceutical purposes (Gerlach 1948) and is a common ornamental plant found throughout North America.…”

Section: Datura Use In North and Central Americamentioning

confidence: 99%

Absorbed Residue Evidence for PrehistoricDaturaUse in the American Southeast and Western Mexico

King¹,

Powis

Cheong

et al. 2018

Adv. archaeol. pract.

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Scholars have been studying absorbed residues for many years looking for evidence of ancient foodrelated cultural practices (Barnard and Eerkens 2007;Evershed et al. 1990;Evershed et al. 1992). This is ABSTRACT Absorbed residue studies have been used in subsistence research for decades. Only more recently have the chemical methods employed been used to explore the consumption of ritual concoctions such as those including cacao, yaupon holly, and alcohol. In this article we use mass spectrometry to identify Datura residues in prehistoric contexts from western Mexico and the American Southeast. Datura is a genus of flowering plants that contain hallucinogenic alkaloids. Their use in both regions is known historically and still continues today. This study sampled 55 pottery vessels and 18 shell vessels using both a traditional burr method and a water-based sonicator sampling method. Datura residues were found in 13 pottery vessels and 14 shell vessels using both sampling approaches. These results demonstrate that it is possible to identify Datura residue in pottery and shell vessels and that the use of Datura extends back into prehistory in both regions. The form and decoration of pottery vessels with Datura residues show correlations with specific motifs and themes. Historically, shell vessels were used in the Southeast for the consumption of another ritual beverage, called the Black Drink. The presence of Datura shows that those vessels were used for other kinds of beverages as well.Los estudios de residuos absorbidos han sido utilizado en la investigación de la subsistencia durante décadas. Sólo más recientemente se han utilizado los métodos químicos empleados en estos estudios para explorar el consumo de brebajes rituales tales como los que incluyen cacao, acebo de Yaupon, y alcohol. En este trabajo se utiliza la espectrometría de masas para identificar los residuos de Datura en contextos prehistóricos del oeste de México y el sureste de Estados Unidos. Datura es un género de plantas florecientes que contiene alcaloides alucinógenos. Su uso en ambas regiones es documentado históricamente y continúa en el presente. Para este estudio se analizaron muestras de 55 vasijas de cerámica y 18 vasijas de concha utilizando tanto el método tradicional de rebaba como el método de muestreo en baño de sonicación con agua. Residuos de Datura fueron encontrados en 13 vasijas de cerámica y 14 vasijas de concha utilizando los dos sistemas de muestreo. Estos resultados demuestran que es posible identificar los residuos de Datura en vasijas de cerámica y concha y que el uso de Datura se remonta a la prehistoria en ambas regiones. La forma y decoración de las vasijas de cerámica con restos de Datura muestran correlaciones con motivos y temas específicos. Históricamente, se utilizaron vasijas de concha en el Sureste para el consumo de otra bebida ritual, llamada la Bebida Negra. La presencia de Datura muestra que las vasijas se utilizaron también para otras bebidas. especially the case in the archaeological search for evidence of sub...

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Section: Datura Use In North and Central Americamentioning

confidence: 99%

Absorbed Residue Evidence for PrehistoricDaturaUse in the American Southeast and Western Mexico

King¹,

Powis

Cheong

et al. 2018

Adv. archaeol. pract.

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“…Datureae is comprised of four accepted sections, three of which belong to the genus Datura-Dutra, Stramonium, and Ceratocaulis [20]. The genus was originally known as Stramonium, but Linnaeus, in 1737, renamed it Datura, a likely Latinization of the Sanskrit dhattura [21], a word used to refer to the plant (probably D. metel) in classical texts. There are generally considered to be nine species of Datura, although anywhere from 9-15 are reported in the literature, which can lead to confusion.…”

Section: Description and Taxonomymentioning

confidence: 99%

Alkaloids of the Genus Datura: Review of a Rich Resource for Natural Product Discovery

Cinelli

Jones

2021

Molecules

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The genus Datura (Solanaceae) contains nine species of medicinal plants that have held both curative utility and cultural significance throughout history. This genus’ particular bioactivity results from the enormous diversity of alkaloids it contains, making it a valuable study organism for many disciplines. Although Datura contains mostly tropane alkaloids (such as hyoscyamine and scopolamine), indole, beta-carboline, and pyrrolidine alkaloids have also been identified. The tools available to explore specialized metabolism in plants have undergone remarkable advances over the past couple of decades and provide renewed opportunities for discoveries of new compounds and the genetic basis for their biosynthesis. This review provides a comprehensive overview of studies on the alkaloids of Datura that focuses on three questions: How do we find and identify alkaloids? Where do alkaloids come from? What factors affect their presence and abundance? We also address pitfalls and relevant questions applicable to natural products and metabolomics researchers. With both careful perspectives and new advances in instrumentation, the pace of alkaloid discovery—from not just Datura—has the potential to accelerate dramatically in the near future.

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“…These compounds represent valuable reservoirs of bioactive agents for both medical applications and pest management (Bourgaud et al 2001). Datura plants are notably rich in scopolamine (Shonle and Bergelson, 2000; Gerlach, 2006), which has demonstrated adverse effects on various insects (Hsiao and Fraenkel, 1968; Krug and Proksch, 1993).…”

Section: Introductionmentioning

confidence: 99%

Insecticidal Effects of Datura Species against Major Agricultural Pests

Sharma,

Singh,

Chaturvedi

et al. 2023

Preprint

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Insecticides derived from plants provide environmentally friendly and sustainable options as alternatives to synthetic chemicals. This investigation delves into the insecticidal capabilities of two distinct Datura species, namely, Datura alba and Datura stramonium, in combatting significant pests such asSpodoptera litura, Bemesia tabaci, andCallosobruchus maculatus. Datura plants have a well-documented history of medicinal use and are recognized for their abundant Tropane alkaloid content, which acts as an innate defense mechanism against pests. Hence, the current investigation involved the extraction of chemical compounds from the leaves, flowers, seeds, and roots of both Datura stramonium and Datura alba. Subsequently, these extracts were assessed for efficacy using Spodoptera litura larvae, Bemesia tabaci, andCallosobruchus maculatusin bioassays. The larvicidal experiments encompassed a range of concentrations (3%, 5%, 10%), with larval mortality being documented at multiple time intervals: 6, 12, 24, 48, and 72 hours. The findings from our investigation uncover the notable insecticidal attributes of root, leaf, flower, and seed extracts from bothDatura albaandDatura stramoniumagainst these larvae. These extracts demonstrated distinct mortality rates at various concentrations and exposure durations. This comprehensive analysis imparts crucial knowledge regarding the insecticidal qualities of Datura species and their prospective contributions to sustainable pest control practices. The observed effectiveness of these plant extracts against a spectrum of significant pests hints at their potential as ecological alternatives within integrated pest management strategies.

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Datura innoxia— a potential commercial source of scopolamine

Cited by 11 publications

References 46 publications

Absorbed Residue Evidence for PrehistoricDaturaUse in the American Southeast and Western Mexico

Absorbed Residue Evidence for PrehistoricDaturaUse in the American Southeast and Western Mexico

Alkaloids of the Genus Datura: Review of a Rich Resource for Natural Product Discovery

Insecticidal Effects of Datura Species against Major Agricultural Pests

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