Daunorubicin oral bioavailability enhancement by surface coated natural biodegradable macromolecule chitosan based polymeric nanoparticles

Ahmad, Niyaz; Ahmad, Rizwan; Alam, Md. Aftab; Ahmad, Farhan Jalees; Amir, Mohd; Pottoo, Faheem Hyder; Sarafroz, Md.; Jafar, Mohammed; Umar, Khalid

doi:10.1016/j.ijbiomac.2019.01.142

Cited by 58 publications

(39 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Being a copolymer, PVA consists of poly(vinyl alcohol) and poly(vinyl acetate), with the characteristics of a block copolymer, where the vinyl part displays a hydrophobic nature. This hydrophobic segment of PVA is known to penetrate the organic phase during formulation development, while removal of organic solvent from the polymeric matrix results in entrapment of the PVA segment within the PLGA polymeric matrix [54]. Ultrasonication of the course emulsion reduced the size of the dispersed phase, and thereby the particles of the nanocarrier were found to be uniform in characteristics, within the size range of 93.46 ± 3.94 nm.…”

Section: Batch Independent Variablesmentioning

confidence: 99%

“…Ultrasonication of the course emulsion reduced the size of the dispersed phase, and thereby the particles of the nanocarrier were found to be uniform in characteristics, within the size range of 93.46 ± 3.94 nm. Selection of CH and polymer contents with proper control of processing parameters was conducted as described in our previous articles [28,54], and during the formulation development of CH-loaded PLGA NP, we were able to obtain the size of the optimized particles with the desired mean diameter. The PDIs of the formulations are found to be low, and thus did not show any variations in batches prepared during the entire research period, indicating the formation of unimodal particles.…”

Section: Batch Independent Variablesmentioning

confidence: 99%

“…This indicates that catechin was completely entrapped in the CH-loaded-PLGA-NPs. A broad peak of PLGA and PLGA-NPs was shown between 45 and 55 • C ( Figure 6) [28,54]. DSC thermogram of CS gave an exothermic broad peak at 311.5 • C, which appeared again in DSC thermograms of CS-coated CH-loaded-PLGA-NPs at 311.7 • C. The chitosan peak was recognized again in the thermogram of the CS-coated-PLGA-NPs ( Figure 6), because that coated on the PLGA-NPs and one smaller peak of PLGA at 52.5 • C also shown, possibly owing to the smaller %CS amount, correlate to that percentage of PLGA, but the CH-DSC thermogram peak was also absent in the CS-CH-PLGA-NPs ( Figure 6) [28,54].…”

Section: Differential Scanning Calorimetry (Dsc)mentioning

confidence: 99%

“…Pure catechin hydrate (CH), PVA, PLGA-NPs, CH-loaded-PLGA-NPs, chitosan, and chitosan-coated-CH-loaded-PLGA-NPs were evaluated via ATR. ATR is a tool that works on the basis of FT-IR technology, in which our optimized NPs' surfaces can be analysed qualitatively or quantitatively [54]. Characteristic IR peaks of catechin were observed at 3341.…”

Section: Atr Analysis Based On Ftirmentioning

confidence: 99%

“…CH was released at a maximum via optimized NPs containing hydrophilic glycolide units of PLGA-NPs, which enhanced the release up to 12.0 h, after which CH was released in a sustained form. The hydrophilic nature of PLGA was enhanced, which is responsible for the enhancement of water permeability of optimized NPs' surface, resulting in an enhanced quantity of CH release [28,54]. Furthermore, PLGA showed smaller hydrophilicity in comparison with CS, which produces a higher hydration of optimized NPs' matrix, and thus a maximum quantity of CH was released [28,34,54].…”

Section: In Vitro Ch Release Evaluationmentioning

confidence: 99%

See 4 more Smart Citations

Quantification and Evaluations of Catechin Hydrate Polymeric Nanoparticles Used in Brain Targeting for the Treatment of Epilepsy

et al. 2020

Self Cite

View full text Add to dashboard Cite

To formulate novel chitosan (CS)-coated–PLGA–nanoparticles (NPs) using a central composite design approach and use them in order to improve brain bioavailability for catechin hydrate (CH) through direct nose-to-central nervous system (CNS) delivery for the evaluation of a comparative biodistribution study of CH by the newly developed ultra high performance liquid chromatography mass spectroscopy and mass spectroscopy (UHPLC-MS/MS) method in the treatment of epilepsy. For PLGA–NPs’ preparation, a double emulsion-solvent evaporation method was used, where a four-factor, three-level central composite design was used to obtain the best nanoformulation. For the optimization, four independent variables were chosen, that is, PLGA, polyvinyl alcohol (PVA), sonication time, and temperature. The optimized PLGA–NPs were further coated with chitosan and assessed for drug release, nasal permeation study, as well as a comparative pharmacokinetic and pharmacodynamic study. Independent and dependent variables helped to optimize the best nanoformulation based on the composition of PLGA (50.0 mg), PVA (1.10%), sonication time (90.0 s), and temperature (25.0 °C). The values of dependent variables were observed, such as polydispersity index (PDI), particle size, and zeta potential (ZP)—that is, 0.106 ± 0.01, 93.46 ± 3.94 nm, and −12.63 ± 0.08 mV, respectively. The ZPs of CS-coated PLGA–NPs were changed from negative to positive value with some alteration in the distribution of particle size. Excellent mucoadhesive-nature of CS–CH–PLGA–NPs as compared with CH–S and CH–PLGA–NPs was seen, with a retention time of 0.856 min and m/z of 289.23/245.20 for CH, together with a retention time of 1.04 min and m/z of 301.21/151.21 for Quercetin as an internal standard (IS). For a linear range (1–1000 ng mL−1), % accuracy (93.07–99.41%) and inter- and intraday % precision (0.39–4.90%) were determined. The improved Cmax with area under curve (AUC)0–24 was found to be highly significant (p < 0.001) in Wistar rats’ brain as compared with the i.n. and i.v. treated group based on the pharmacokinetics (PK) results. Furthermore, CS–CH–PLGA–NPs were found to be more significant (p < 0.001) for the treatment of seizure threshold rodent models, that is, increasing current electroshock and pentylenetetrazole-induced seizures. A significant role of CS–CH–PLGA–NPs was observed, that is, p < 0.001, for the enhancement of brain bioavailability and the treatment of epilepsy.

show abstract

Section: Batch Independent Variablesmentioning

confidence: 99%

Section: Batch Independent Variablesmentioning

confidence: 99%

Section: Differential Scanning Calorimetry (Dsc)mentioning

confidence: 99%

Section: Atr Analysis Based On Ftirmentioning

confidence: 99%

Section: In Vitro Ch Release Evaluationmentioning

confidence: 99%

See 3 more Smart Citations

Quantification and Evaluations of Catechin Hydrate Polymeric Nanoparticles Used in Brain Targeting for the Treatment of Epilepsy

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

Investigations into the characterization, degradation, and applications of biodegradable polymers by mass spectrometry

Rizzarelli,

Leanza,

Rapisarda

2023

Mass Spectrometry Reviews

View full text Add to dashboard Cite

Biodegradable polymers have been getting more and more attention because of their contribution to the plastic pollution environmental issues and to move towards a circular economy. Nevertheless, biodegradable materials still exhibit various disadvantages restraining a widespread use in the market. Therefore, additional research efforts are required to improve their performance. Mass spectrometry (MS) affords a relevant contribution to optimize biodegradable polymer synthesis, to confirm macromolecular structures, to examine along the time the progress of degradation processes and highlight advantages and drawbacks in the extensive applications. This review aims to provide an overview of the MS investigations carried out to support the synthesis of biodegradable polymers, with helpful information on undesirable products or polymerization mechanism, to understand deterioration pathways by the structure of degradation products and to follow drug release and pharmacokinetic. Additionally, it summarizes MS studies addressed on environmental and health issues related to the extensive use of plastic materials, that is, potential migration of additives or microplastics identification and quantification. The paper is focused on the most significant studies relating to synthetic and microbial biodegradable polymers published in the last 15 years, not including agro‐polymers such as proteins and polysaccharides.

show abstract

Mass spectrometry in bioresorbable polymer development, degradation and drug‐release tracking

Rizzarelli

Rapisarda

Valenti

2020

Rapid Comm Mass Spectrometry

View full text Add to dashboard Cite

A detailed characterization of polymeric matrices and appropriate degradation monitoring techniques are required to sustain the development of new materials as well as to enlarge the applications of the old ones. In fact, polymer analysis is essential for the clarification of the intrinsic relationship between structure and properties that ascertains the industrial applications in diverse fields. In bioresorbable and biodegradable polymers, the role of analytical methods is dual since it is pointed both at the polymeric matrices and at degradation tracking. The structural architectures, the mechanical and morphological properties, and the degradation rate, are of outstanding importance for a specific application. In some cases, the complexity of the polymer structure, the processes of decomposition or the low concentration of the degradation products need the concurrent use of different complementary analytical techniques to give detailed information of the reactions taking place. Several analytical methods are used in bioresorbable polymer development and degradation tracking. Among them, mass spectrometry (MS) plays an essential role and it is used to refine polymer syntheses, for its high sensitivity, to highlight degradation mechanism by detecting compounds present in trace amounts, or to track the degradation product profile and to study drug release. In fact, elucidation of reaction mechanisms and polymer structure, attesting to the purity and detecting defects as well as residual catalysts, in biodegradable and bioresorbable polymers, requires sensitive analytical characterization methods that are essential in providing an assurance of safety, efficacy and quality. This review aims to provide an overview of the MS strategies used to support research and development of resorbable polymers as well as to investigate their degradation mechanisms. It is focused on the most significant studies concerning synthetic bioresorbable matrices (polylactide, polyglycolide and their copolymers, polyhydroxybutyrate, etc.), published in the last ten years.

show abstract

Daunorubicin oral bioavailability enhancement by surface coated natural biodegradable macromolecule chitosan based polymeric nanoparticles

Cited by 58 publications

References 48 publications

Quantification and Evaluations of Catechin Hydrate Polymeric Nanoparticles Used in Brain Targeting for the Treatment of Epilepsy

Quantification and Evaluations of Catechin Hydrate Polymeric Nanoparticles Used in Brain Targeting for the Treatment of Epilepsy

Investigations into the characterization, degradation, and applications of biodegradable polymers by mass spectrometry

Mass spectrometry in bioresorbable polymer development, degradation and drug‐release tracking

Contact Info

Product

Resources

About